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Pure Pineal Germinoma in a 17-Year-Old Adolescent: A Case Report and Literature Review
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 1 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 2 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 3 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 4 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 5 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 6 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
- 7 Medical Oncology Department, Hassan II University Hospital, Fez, Morocco
Journal of Cancer Therapy·Volume 17 (2026)·Pages 36–44·Published 2 January 2026·DOI10.4236/jct.2026.171005
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Abstract
We report the case of a 17-year-old adolescent presenting with a large pineal region mass initially interpreted as a ruptured mature teratoma with intraventricular dissemination, complicated by triventricular hydrocephalus. Stereotactic biopsy enabled a definitive diagnosis of a pure germinoma, confirmed by its immunohistochemical profile (SALL4+, PLAP+, CD117+, CK−). The patient received three cycles of BEP chemotherapy (bleomycin, etoposide, cisplatin) followed by panventricular irradiation (24 Gy) with an additional tumor boost (16 Gy), resulting in good treatment tolerance and sustained radiologic stabilization. This case highlights the diagnostic challenges in distinguishing germinoma from teratoma on imaging, underscores the importance of stereotactic biopsy, and illustrates the effectiveness of combined chemoradiotherapy in intracranial germinomas.
KeywordsIntracranial GerminomaIntracranial Germ Cell TumorPineal RegionBEP RegimenPanventricular Radiotherapy
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