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Characteristics and Outcomes of a Cohort of 34 Patients with Testicular Germ Cell Tumors: A Single-Center Experience at Hassan II University Hospital of Fez
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 1 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 2 Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 3 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 4 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 5 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 6 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 7 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 8 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 9 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 10 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 11 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 12 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
- 13 Department of Medical Oncology, Hassan II University Hospital Center, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Journal of Cancer Therapy·Volume 17 (2026)·Pages 168–177·Published 2 February 2026·DOI10.4236/jct.2026.172016
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Abstract
Introduction : Testicular germ cell tumors (TGCTs) are rare but account for more than 90% of testicular cancers. They mainly affect young men and have a high cure potential. This study aimed to describe the characteristics, management, and prognosis of TGCTs treated at Hassan II University Hospital of Fez. Materials and Methods : This monocentric retrospective study included 34 patients treated for TGCTs between May 2017 and December 2022. Epidemiological, clinical, therapeutic, and survival data were collected from medical records. Results : The mean age was 34 years (range: 16 - 66). Testicular enlargement was the main presenting symptom (75%). All diagnoses were confirmed by orchiectomy. According to the AJCC classification, 34% of patients were stage I, 28% stage II, and 38% stage III. Based on the IGCCCG prognostic classification, 50% of patients had a good prognosis and 50% had an intermediate prognosis. The BEP regimen was the most commonly used first-line chemotherapy. After a median follow-up of 4 years, overall survival (OS) was 90% and progression-free survival (PFS) was 85%. For seminomas, 4-year OS was 91% and PFS was 86%. For non-seminomatous tumors, OS was 85% and PFS was 80%. Conclusion : This series confirms the excellent prognosis of TGCTs in a Moroccan context, with survival outcomes comparable to international standards. It highlights the importance of standardized management according to stage and histological subtype.
KeywordsTesticular Germ Cell TumorSeminomaNon-Seminomatous TumorChemotherapyPrognosisMorocco
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