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Advancements in Suppression of Osteosarcoma Tumorigenicity: A Prospective Look
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
- 1 Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 2 Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 3 Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 4 Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 5 Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
- 6 Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Journal of Cancer Therapy·Volume 03 (2012)·Pages 327–330·Published 9 August 2012·DOI10.4236/jct.2012.34042
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Abstract
Bone morphogenetic proteins (BMPs) promote differentiation of stem cells into bone cells. Results from our pilot studies indicate these proteins are also capable of inducing the differentiation of stem-like cells that initiate and propagate osteosarcoma, a rare, highly malignant primary bone tumor affecting primarily children and adolescents. Our plans to evaluate the use of BMP as adjuvant therapy to suppress bone tumor while facilitating skeletal reconstruction are reviewed.
KeywordsBMP-2OsteosarcomaCancer Stem CellsAldehyde Dehydrogenase
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