Assessing Patient Outcomes after Palliative Radiotherapy Using IG-IMRT
- 1 The Ottawa Hospital Cancer Centre, Ottawa, Canada
- 2 Northeastern Ontario Regional Cancer Centre, Sudbury, Canada
- 3 Faculty of Medicine, University of Ottawa, Ottawa, Canada
Abstract
Purpose: To assess clinical outcomes after using IG-IMRT for palliation among patients with advanced cancers. Methods: Patients with advanced and/or metastatic cancers were treated on our Tomo-PAL (Tomotherapy?-Planning and Administration Linked) protocol using helical TomoTherapy? and evaluated to assess clinical efficacy of treatment as well as to assess side effects. Results: A total of 40 patients were treated to 40 sites from Feb 2007 to May 2009. There were 25 men and 15 women with a median age of 70 years (range 16 - 94). Pain and bleeding were the most common symptoms being palliated (80% and 12.5% respectively). The dose prescribed ranged from 5 - 25 Gy in 1 - 5 fractions. A qualitative improvement in symptoms was documented in 82% of patients (75% partial relief and 7% complete relief) and major side effects were not encountered. Conclusions: IG-IMRT can be used for palliation and produces response rates that compare favourably with those reported in the published literature.
- J. P. Ciezki, S. Komurcu and R. M. Macklis, “Palliative Radiotherapy,” Seminars in Oncology, Vol. 27, No. 1, 2000, pp. 90-93.
- D. Hoegler, “Radiotherapy for Palliation of Symptoms in Incurable Cancer,” Current Problems in Cancer, Vol. 21, No. 3, 1997, pp. 129-183. doi:10.1016/S0147-0272(97)80004-9
- M. Ashby, “The Role of Radiotherapy in Palliative Care,” Journal of Pain and Symptom Management, Vol. 6, No. 6, 1991, pp. 380-388. doi:10.1016/0885-3924(91)90030-8
- G. Stevens and I. Firth, “Clinical Audit in Radiation Oncology: Results from One Centre,” Australasian Radiology, Vol. 40, No. 1, 1996, pp. 47-54. doi:10.1111/j.1440-1673.1996.tb00345.x
- M. V. Williams, N. D. James, E. T. Summers, A. Barrett and D. V. Ash, “On Behalf of the Audit Sub-Committee, Faculty of Clinical Oncology and the Royal College of Radiologists National Survey of Radiotherapy Fractionation Practice in 2003,” Clinical Oncology (Royal College of Radiologists), Vol. 18, No. 1, 2006, pp. 3-14. doi:10.1016/j.clon.2005.10.002
- R. Andrade, et al., “A Simple and Effective Daily Pain Management Method for Patients Receiving Radiation Therapy for Painful Bone Metastasis,” International Journal of Radiation Oncology*Biology*Physics, Vol. 78, No. 3, 2010, pp. 855-859.
- L. Vakeat and T. Boterberg, “Pain Control by Ionizing Radiation of Bone Metastasis,” International Journal of Developmental Biology, Vol. 48, No. 5-6, 2004, pp. 599-606. doi:10.1387/ijdb.041817lv
- M. Van den Beuken-van Everdingen, et al., “Prevalence of Pain in Patients with Cancer: A Systematic Review of the past 40 Years,” Annals of Oncology, Vol. 18, No. 9, 2007, pp. 1437-1449. doi:10.1093/annonc/mdm056
- R. Samant and A. C. Gooi, “Radiotherapy Basics for Family Physicians: Potent Tool for Symptom Relief,” Canadian Family Physician, Vol. 51, No. 11, 2005, pp. 1496-1501.
- A. Konski, S. Feigenberg and E. Chow, “Palliative Radiation Therapy,” Seminars in Oncology, Vol. 32, No. 2, 2005, pp. 156-164. doi:10.1053/j.seminoncol.2004.11.013
- M. MacPherson, et al., “On-Line Rapid Palliation Using Helical Tomotherapy: A Prospective Feasibility Study,” Radiotherapy and Oncology, Vol. 87, No. 1, 2008, pp. 116-118. doi:10.1016/j.radonc.2008.01.017
- R. Samant, L. Gerig, L. Montgomery, R. Macrae, et al., “High-Technology Palliative Radiotherapy Using Image-Guided Intensity-Modulated Radiotherapy,” Clinical Oncology (Royal College of Radiologists), Vol. 20, No. 9, 2008, pp. 718-720. doi:10.1016/j.clon.2008.08.002