Expressions of CCR7 and CXCR4 Are Associated with Differentiation in Gastrointestinal Cancer
- 1 Department of Oncology, Gongli Hospital, Shanghai, China.
- 2 Department of Oncology, Gongli Hospital, Shanghai, China.
- 3 Department of Oncology, Gongli Hospital, Shanghai, China.
- 4 Department of Oncology, Gongli Hospital, Shanghai, China.
- 5 Department of Oncology, Gongli Hospital, Shanghai, China.
- 6 Department of Oncology, Gongli Hospital, Shanghai, China.
Abstract
Purpose : The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer invasion and metastasis . This study was aimed to investigate CCR7 and CXCR4 expressions and evaluate the association between their expressions and the clinicopathological features in gastrointestinal cancer. Method : 27 paired tissue samples from patients who had curative surgery for gastrointestinal cancer were obtained. Quantitative real-time PCR, immunochemistry assay and western blot analysis were carried out to investigate the expressions of CCR7, CXCR4 expressions in gastrointestinal cancer. Results : The cancer tissues expressed significant higher level of CCR7 (P = 0.000) and CXCR4 (P = 0.000) protein than the adjacent normal mucosa. Expression s of CCR7 (P = 0.002) and CXCR4 (P = 0.003) protein in cancer tissues exhibited significant correlation with differentiation in gastrointestinal cancer. Conclusion : E xpression s of CCR7 and CXCR4 protein were associated with differentiation in gastrointestinal cancer . CCR7 and CXCR4 may be predictive factors for poor prognosis in patients with gastrointestinal cancer.
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