Reversal of Cancer by Dual Strategy?
- 1 Laboratorio y Servicio de Bioquímica Experimental, Clínica and Hospital Universitario Puerta de Hierro, Madrid, Spain.
Abstract
I present herewith a concise historic account of our development of the new technique for cancer therapy: Reversal of Cancer by Dual Strategy. This new method is based on the possible correction of the mitochondrial filamentation defect of tumors plus minor cytotoxicity addressed to the anoxic and fagocitic tumor ’ s redoubts, using the administration of the anticancer agents with a chrono-therapeutic emphasis on the patient ’ s mobility. Such methods probably will reach patients in the near future with the collaboration of private clinical trials mainly at least in the USA, Europe and Japan. Only the more essential references of this effort are provided.
- A. V. Hsie and T. T. Puck, “Reversion of Hamster Kidney Epithelial Cells with Cyclic AMP,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 68, No. 2, 1971, pp. 358-361. doi:10.1073/pnas.68.2.358
- G. S. Johnson, R. H. Friedman and I. Pastan, “Morphological Change of Epithelial Cells after Treatment with Dibutyril Cyclic AMP,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 68, No. 2, 1971, pp. 425-429. doi:10.1073/pnas.68.2.425
- C. Friend, W. Scher, J. G. Holland and T. Sato, “Normal Differentiation of Leukemia Cells,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 68, 1971, p. 3678.
- T. T. Puck, “Reverse Transformation, Membranes, Cancer and Microfilaments,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 10, 1977, pp. 4491-4495. doi:10.1073/pnas.74.10.4491
- Y. Honma, T. Kasukabe, J. Okabe and M. Hozumi, “Prolongation of Survival Time of Mice Inoculated with Myeloid Leukemia Cells by Inducers of Normal Differentiation,” Cancer Research, Vol. 39, No. 8, 1978, pp. 3167-3171.
- M. Gosálvez, “Bases for the Design of Pharmacological Effectors Acting on Plasma Membrane Receptors,” Biochemical Society Transactions, Vol. 9, No. 1, 1981, pp. 151-152.
- M. Gosálvez y Gosálvez, “The Zipper Mechanism,” Madrid, 1982.
- M. Gosálvez, C. Vivero and I. Alvarez, “Restoration of ‘Contact Inhibition’ in Tumor Cells in Tissue Culture with Thiazolidin-4-Carboxylic Acid,” Biochemical Society Transactions, Vol. 7, 1979, pp. 191-192.
- M. Gosálvez, “Thioproline and Reversal of Cancer,” Lancet, Vol. 321, No. 8333, 1983, p. 1108. doi:10.1016/S0140-6736(83)91947-5
- A. Brugarolas and M. Gosálvez, “Treatment of Cancer by an Inducer of Reverse Transformation,” Lancet, Vol. 315, No. 8159, 1980, pp. 68-70. doi:10.1016/S0140-6736(80)90494-8
- Editorial, “Reversal of Cancer,” Lancet, Vol. 1, 1983, pp. 799-800.
- F. Boccardo, A. Barbieri, L. Canobbio, D. Guarneri, M. Merlano and R. Rossi, “Phase II Trial of Thioproline in Advanced Epidermoid Head and Neck Tumors,” Cancer Treatment Reports, Vol. 66, 1982, p. 585.
- P. Alberto, “Thioproline (Norgamem): A Useless Drug in the Treatment of Squamous Cell Carcinoma,” European Journal of Cancer, Vol. 17, No. 9, 1981, pp. 1061-1062. doi:10.1016/S0277-5379(81)80014-4