Cervical cancer is the one of the most common cancer in female patients inThailand. Radiotherapy has the role for the treatment of cervical cancer by postoperative, radical and palliative treatments. For radical radiotherapy, the combina tion of external beam radiation therapy and brachytherapy will be used to increase the tumor dose to curative goal. With the new development of medical images (Computed tomography (CT), Magnetic Resonance Imaging (MRI) or Ultra sonography (US)), the treatment with brachytherapy will be developed from point-based to volume-based concepts. Many studies reported the benefit of image-based brachytherapy over conventional brachytherapy and clinical benefit of using image-based brachytherapy in the treatment of cervical cancer.
P. Kamnerdsupaphon, S. Srisukho, Y. Sumitsawan, V. Lorvidhaya and V. Sukthomya, “Cancers in Northern Thailand,” Biomedical Imaging and Intervention Journal, Vol. 4, No. 3, 2008, p. e46. doi:10.2349/biij.4.3.e46
P. G. Rose, B. N. Bundy, E. B. Watkins, J. T. Thigpen, G. Deppe, M. A. Maiman, et al., “Concurrent CisplatinBased Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer,” New England Journal of Medicine, Vol. 340, No. 15, 1999, pp. 1144-1153. doi:10.1056/NEJM199904153401502
H. M. Keys, B. N. Bundy, F. B. Stehman, L. I. Muderspach, W. E. Chafe, C. L. Suggs 3rd, et al., “Cisplatin, Radiation, and Adjuvant Hysterectomy Compared with Radiation and Adjuvant Hysterectomy for Bulky Stage IB Cervical Carcinoma,” New England Journal of Medicine, Vol. 340, No. 15, 1999, pp. 1154-1161. doi:10.1056/NEJM199904153401503
P. J. Eifel, K. Winter, M. Morris, C. Levenback, P. W. Grigsby, J. Cooper, et al., “Pelvic Irradiation with Concurrent Chemotherapy versus Pelvic and Para-aortic Irradiation for High-Risk Cervical Cancer: An Update of Radiation Therapy Oncology Group Trial (RTOG) 90-01,” Journal of Clinical Oncology, Vol. 22, No. 5, 2004, pp. 872-880. doi:10.1200/JCO.2004.07.197
M. Tod and W. J. Meredith, “Treatment of Cancer of the Cervix Uteri, a Revised Manchester Method,” British Journal of Radiology, Vol. 26, No. 305, 1953, pp. 252-257. doi:10.1259/0007-1285-26-305-252
C. Haie-Meder, R. Ptter, E. Van Limbergen, I. Barillot, M. De Brabandere, J. Dimopoulos, et al., “Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): Concepts and Terms in 3D Image Based 3D Treatment Planning in Cervix Cancer Brachytherapy with Emphasis on MRI Assessment of GTV and CTV,” Radiotherapy & Oncology, Vol. 74, No. 3, 2005, pp. 235-245. doi:10.1016/j.radonc.2004.12.015
R. Potter, C. Haie-Meder, E. Van Limbergen, I. Barillot, M. De Brabandere, J. Dimopoulos, et al., “GEC ESTRO Working Group. Recommendations from Gynecological (GYN) GEC ESTRO Working Group (II): Concepts and Terms in 3D Image-Based Treatment Planning in Cervix Cancer Brachytherapy-3D Dose Volume Parameters and Aspects of 3D Image-Based Anatomy, Radiation Physics, Radiobiology,” Radiotherapy & Oncology, Vol. 78, No. 1, 2006, pp. 67-77. doi:10.1016/j.ra donc.2005.11.014
M. De Brabandere, A. G. Mousa, A. Nulens, A. Swinnen and E. Van Limbergen, “Potential of Dose Optimisation in Mri-Based PDR Brachytherapy of Cervix Carcinoma,” Radiotherapy & Oncology, Vol. 88, No. 2, 2008, pp. 217-226. doi:10.1016/j.radonc.2007.10.026
S. K. Vinod, K. Caldwell, A. Lau and A. R. Fowler, “A Comparison of ICRU Point Doses and Volumetric Doses of Organs at Risk (OARs) in Brachytherapy for Cervical Cancer,” Journal of Medical Imaging and Radiation Oncology, Vol. 55, No. 3, 2011, pp. 304-310. doi:10.1111/j.1754-9485.2011.02272.x
K. Tanderup, S. K. Nielsen, G. B. Nyvang, E. M. Pedersen, L. R?hl, T. Aagaard, et al., “From Point A to the Sculpted Pear: MR Image Guidance Significantly Improves Tumour Dose and Sparing of Organs at Risk in Brachytherapy of Cervical Cancer,” Radiotherapy & Oncology, Vol. 94, No. 2, 2010, pp. 173-180. doi:10.1016/j.radonc.2010.01.001
A. D. Wanderas, M. Sundset, I. Langdal, S. Danielsen, G. Frykholm and A. B. Marthinsen, “Adaptive Brachytherapy of Cervical Cancer, Comparison of Conventional Point A and CT Based Individual Treatment Planning,” Acta Oncologica, Vol. 51, No. 3, 2012, pp. 345-354. doi:10.3109/028 4186X.2011.626446
D. Zwahlen, J. Jezioranski, P. Chan, M. A. Haider, Y. B. Cho, I. Yeung, et al., “Magnetic Resonance ImagingGuided Intracavitary Brachytherapy for Cancer of the Cervix,” International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 4, 2009, pp. 1157-1164. doi:10.1016/j.i jrobp.2008.09.010
E. Tharavichitkul, S. Mayurasakorn, V. Lorvidhaya, V. Sukthomya, S. Wanwilairat, S. Lookaew, et al., “Preliminary Results of Conformal Computed Tomography (CT)-based Intracavitary Brachytherapy (ICBT) for Locally Advanced Cervical Cancer: A Single Institution’s Experience,” Journal of Radiation Research, Vol. 52, No. 5, 2011, pp. 634-640. doi:10.1269/jrr.10154
E. Tharavichitkul, C. Sivasomboon, S. Wanwilairat, V. Lorvidhaya, V. Sukthomya, S. Chakrabhandu, et al., “Preliminary Results of MRI-Guided Brachytherapy in Cervical Carcinoma: The Chiangmai University Experience,” Journal of Radiation Research, Vol. 53, No. 2, 2012, pp. 313-318. doi:10.1269/jrr.11107
R. P?tter, P. George, J. C. Dimopoulos, M. Grimm, D. Berger, N. Nesvacil, et al., “Clinical Outcome of Protocol Based Image (MRI) Guided Adaptive Brachytherapy Combined with 3D Conformal Radiotherapy with or without Chemotherapy in Patients with Locally Advanced Cervical Cancer,” Radiotherapy & Oncology, Vol. 100, No. 1, 2011, pp. 116-123. doi:10.1016/j.radonc.2011.07.012
J. C. Dimopoulos, S. Lang, C. Kirisits, E. F. Fidarova, D. Berger, P. Georg, et al., “Dose-Volume Histogram Parameters and Local Tumor Control in Magnetic Resonance Image-Guided Cervical Cancer Brachytherapy,” International Journal of Radiation Oncology Biology Physics, Vol. 75, No. 1, 2009, pp. 56-63. doi:10.1016/j.ijrobp.2008.10.033
P. Georg, S. Lang, J. C. Dimopoulos, W. Dorr, A. E. Sturdza, D. Berger, et al., “Dose-Volume Histogram Parameters and Late Side Effects in Magnetic Resonance Image-Guided Adaptive Cervical Cancer Brachytherapy,” International Journal of Radiation Oncology Biology Physics, Vol. 79, No. 2, 2011, pp. 356-362. doi:10.1016/j.ij robp.2009.11.002
A. N. Viswanathan, J. Dimopoulos, C. Kirisits, D. Berger and R. Potter, “Computed Tomography versus Magnetic Resonance Imaging-Based Contouring in Cervical Cancer Brachytherapy: Results of a Prospective Trial and Preliminary Guidelines for Standardized Contours,” International Journal of Radiation Oncology Biology Physics, Vol. 68, No. 2, 2007, pp. 491-498. doi:10.1016/j.i jrobp.2006.12.021
R. N. Eskander, D. Scanderbeg, C. C. Saenz, M. Brown and C. L. Yashar, “Comparison of Computed Tomography and Magnetic Resonance Imaging in Cervical Cancer Brachytherapy Target and Normal Tissue Contouring,” International Journal of Gynecological Cancer, Vol. 20, No. 1, 2010, pp. 47-53. doi:10.1111/IGC.0b013e3181c4a627
R. Krishnatry, F. D. Patel, P. Singh, S. C. Sharma, A. S. Oinam and A. K. Shukla, “CT or MRI for Image-based Brachytherapy in Cervical Cancer,” Japanese Journal of Clinical Oncology, Vol. 42, No. 4, 2012, pp. 309-313. doi:10.1093/jjco/hys010
L. T. Tan, C. E. Coles, C. Hart and E. Tait, “Clinical Impact of Computed Tomography-Based Imaged-Guided Brachytherapy for Cervix Cancer Using the Tandem-Ring Applicator—The Addenbrooke’s Experience,” Clinical Oncology, Vol. 21, No. 3, 2009, pp. 175-182. doi:10.1016/j.clon.2008.12.001
S. Van Dyk, K. Narayan, R. Fisher and D. Bernshaw, “Conformal Brachytherapy Planning for Cervical Cancer Using Transabdominal Ultrasound,” International Journal of Radiation Oncology Biology Physics, Vol. 75, No. 1, 2009, pp. 64-70. doi:10.1016/j.ijrobp.2008.10.057
U. Mahantshetty, N. Khanna, J. Swamidas, R. Engineer, M. H. Thakur, N. H. Merchant, et al., “Trans-Abdominal Ultrasound (US) and Magnetic Resonance Imaging (MRI) Correlation for Conformal Intracavitary Brachytherapy in Carcinoma of the Uterine Cervix,” Radiotherapy & Oncology, Vol. 102, No. 1, 2012, pp. 130-134. doi:10.1016/j.radonc.2011.08.001
P. Trnkova, R. Poetter, D. Baltas, A. Karabis, E. Fidarova, J. Dimopoulos, et al., “New Inverse Planning Technology for Image-Guided Cervical Cancer Brachytherapy: Description and Evaluation within a Clinical Frame,” Radiotherapy & Oncology, Vol. 93, No. 2, 2009, pp. 331-340. doi:10.1016/j.ra donc.2009.10.004
E. Chajon, I. Dumas, M. Touleimat, N. Magné, J. Coulot, R. Verstraet, et al., “Inverse-Planning Approach for 3-D MRI-Based Pulse-Dose Rate Intracavitary Brachytherapy in Cervix Cancer,” International Journal of Radiation Oncology Biology Physics, Vol. 69, No. 3, 2007, pp. 955-961. doi:10.1016/j.ijrobp.2007.07.2321
D. H. Kim, A. Wang-Chesebro, V. Weinberg, J. Poulot, L. M. Chen, J. Speight, et al., “High-Dose Rate Brachytherapy Using Inverse Planning Simulated Annealing for Locoregionally Advanced Cervical Cancer: A Clinical Report with 2-yr Follow-Up,” International Journal of Radiation Oncology Biology Physics, Vol. 75, No. 5, 2009, pp. 1329-1334. doi:10.1016/j.ijrobp.2009.01.002