Advanced Breast Angiosarcoma Completely Responding to Chemotherapy

Abstract

Introduction : For patients with anthracycline - resistant metastatic angiosarcoma, currently there is no available stan dard for second-line therapy and there is a need for novel effective regimens to improve response rates. Case report : We reported here about a case of a primary angiosarcoma of both breasts in a 34-year-old woman presenting lung me tastases. At the completion of 3 cycles of the MAID regimen including mesna, adriamycin, ifosfamide and dacarbazine, CT showed progression of the disease (PD). Subsequently second-line chemotherapy was started using GVP regimen consisting of gemcitabine, vincristine and cisplatin. Complete response (CR) of the lung metastases was achieved after 6 treatment cycles. Conclusion : In the absence of an effective therapy among patients with anthracycline - resistant metastatic breast angiosarcoma, a GVP chemo-regimen can be performed as a selective option.