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Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis
Department of Biology, University of Naples Federico II, Naples, Italy
Department of Biology, University of Naples Federico II, Naples, Italy
National Cancer Institute “G. Pascale”, Naples, Italy
National Cancer Institute “G. Pascale”, Naples, Italy
National Cancer Institute “G. Pascale”, Naples, Italy
Department of Biology, University of Naples Federico II, Naples, Italy
Unit of Dermatology, “Ascalesi” Hospital, Naples, Italy
- 1 Department of Biology, University of Naples Federico II, Naples, Italy
- 2 Department of Biology, University of Naples Federico II, Naples, Italy
- 3 National Cancer Institute “G. Pascale”, Naples, Italy
- 4 National Cancer Institute “G. Pascale”, Naples, Italy
- 5 National Cancer Institute “G. Pascale”, Naples, Italy
- 6 Department of Biology, University of Naples Federico II, Naples, Italy
- 7 Unit of Dermatology, “Ascalesi” Hospital, Naples, Italy
Journal of Cancer Therapy·Volume 04 (2013)·Pages 56–59·Published 4 July 2013·DOI10.4236/jct.2013.46A1009
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Abstract
Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study , we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species pro duction in some patients affected by severe photoaging and actinic keratosis .
KeywordsPhotoagingActinic KeratosisMnSODSkin Cancer Lesions
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