Research ArticleOpen AccessGoogle Scholar indexed
Management of the Case of a Young Female Patient with Multiple Malignancies and Germline R24P CDKN2A Gene Mutation
Department of Oncotherapy, University of Szeged, Szeged, Hungary; 2Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
Department of Oncotherapy, University of Szeged, Szeged, Hungary
Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
Department of Pathology, University of Szeged, Szeged, Hungary
Department of Radiology, University of Szeged, Szeged, Hungary
Department of Oncotherapy, University of Szeged, Szeged, Hungary
Department of Surgery, University of Szeged, Szeged, Hungary
Department of Surgery, University of Szeged, Szeged, Hungary
Department of Oncotherapy, University of Szeged, Szeged, Hungary
- 1 Department of Oncotherapy, University of Szeged, Szeged, Hungary; 2Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
- 2 Department of Oncotherapy, University of Szeged, Szeged, Hungary
- 3 Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
- 4 Department of Dermatology and Immunology, University of Szeged, Szeged, Hungary
- 5 Department of Pathology, University of Szeged, Szeged, Hungary
- 6 Department of Radiology, University of Szeged, Szeged, Hungary
- 7 Department of Oncotherapy, University of Szeged, Szeged, Hungary
- 8 Department of Surgery, University of Szeged, Szeged, Hungary
- 9 Department of Surgery, University of Szeged, Szeged, Hungary
- 10 Department of Oncotherapy, University of Szeged, Szeged, Hungary
Journal of Cancer Therapy·Volume 04 (2013)·Pages 18–20·Published 19 July 2013·DOI10.4236/jct.2013.47A004
Copy link · social · email
Abstract
The case of a young female patient with metachronous primary melanomas, advanced breast and pancreatic cancers is reported. The 5 different tumors diagnosed within six years, were managed with curative intent. Genetic analysis re vealed the mutation of the R24P CDKN2A gene in a heterozygote form in both the patient and her father. Careful terti ary prevention during the follow-up of the patient is needed.
KeywordsBreast CancerMelanomaPancreatic CancerR24P CDKN2A Gene Mutation
- C. G. Demandante, D. A. Troyer and T. P. Miles, “Multiple Primary Malignant Neoplasms: Case Report and a Comprehensive Review of the Literature,” American Journal of Clinical Oncology, Vol. 26, No. 1, 2003, pp. 79-83. doi:10.1097/00000421-200302000-00015
- A. Irimie, P. Achimas-Cadariu, C. Burz and E. Puscas, “Multiple Primary Malignacies—Epidemiological Analysis at a Single Tertiary Institution,” Journal of Gastrointestinal and Liver Diseases, Vol. 19, No. 1, 2010, pp. 69-73.
- R. Agrawal, “Synchronous Dual Malignancy: Successfully Treated Cases,” Journal of Cancer Research and Therapy, Vol. 3, No. 3, 2007, pp. 153-156. doi:10.4103/0973-1482.37408
- G. Moertel, “Multiple Primary Malignant Neoplasms: Historical Perspectives,” Cancer, Vol. 40, 1977, pp. 1786-1792. doi:10.1002/1097-0142(197710)40:4+ 3.0.CO;2-2
- K. Balogh, E. Nemes, G. Uhercsák, Zs. Kahán, Gy. Lázár, Gy. Farkas, H. Polyánka, E. Kiss, R. Gyulai, E. Varga, E. Kereszt-Határvolgyi, L. Kaizer, L. Haracska, L. Tiszlavicz, L. Kemény, J. Oláh and M. Széll, “Melanoma-PreDisposing CDKN2A Mutations in Association with Breast Cancer: A Case-Study and a Meta-Analysis,” In: M. Murph, Ed., Melanoma in the Clinic—Diagnosis, Management and Complications of Malignancy, InTech, Rijeka, 2011, pp. 211-224.
- C. Monnerat, A. Chompret, C. Kannengiesser, M. F. Avril, N. Janin, A. Spatz, J. M. Guinebretiere, C. Marian, M. Barrois, F. Boitier, G. M. Lenoir and B. Bressac-de Paillerets, “BRCA1, BRCA2, TP53, and CDKN2A Germline Mutations in Patients with Breast Cancer and Cutaneous Melanoma,” Familial Cancer, Vol. 6, No. 4, 2007, pp. 453-461. doi:10.1007/s10689-007-9143-y
- M. Goldstein, “Familial Melanoma, Pancreatic Cancer and Germline CDKN2A Mutations,” Human Mutation, Vol. 23, No. 6, 2004, pp. 630-642. doi:10.1002/humu.9247
- M. Goldstein, M. C. Fraser, J. P. Struewing, C. J. Hussussian, K. Ranade, D. P. Zametkin, L. S. Fontaine, S. M. Organic, N. C. Dracopoli and W. H. Clark, “Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds with p16INK4 Mutations,” The New England Journal of Medicine, Vol. 333, No. 15, 1995, pp. 970-974. doi:10.1056/NEJM199510123331504
- P. Ghiorzo, G. Fornarini, S. Sciallero, et al., “CDKN2A Is the Main Susceptibility Gene in Italian Pancreatic Cancer Families,” Journal of Medical Genetics, Vol. 49, No. 3, 2012, pp. 164-170. doi:10.1136/jmedgenet-2011-100281
- S. Solomon, S. Das, R. Brand and D. C. Whitcomb, “Inherited Pancreatic Cancer Syndromes,” The Cancer Journal, Vol. 18, No. 6, 2012, pp. 485-491. doi:10.1097/PPO.0b013e318278c4a6