Do All Prostate Cancers Behave the Same?

Abstract

Two different immunohistochemical types suggestive of Large Cell Neuroendocrine (NE) carcinoma and Adenoc a rc i noma in a patient with known diffusely metastatic, hormone refractory prostate carcinoma are rarit ies . Interestingly, our patient had documented history of exposure to Agent Orange during his time of service. The use of routinely used immunohistochemical stains for pathological diagnosis was a challenge in this case, though throughout his disease course, the diagnosis was confirmed as Adenocarcinoma of prostate with biopsies from all various sites of metastas e s. Systemic chemotherapy has been historically suboptimal in management of aggressively behaved prostate carcinomas. Finding any association of Agent Orange as a causative etiology and improving diagnosis and management of such aggressive hormone refractory prostate carcinoma need further investigation s .