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Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 1 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 2 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 3 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 4 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 5 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 6 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 7 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 8 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 9 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
- 10 Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Journal of Cancer Therapy·Volume 05 (2014)·Pages 766–768·Published 7 July 2014·DOI10.4236/jct.2014.58085
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Abstract
Pemetrexed is an antimetabolic agent and is well-known as a potent inhibitor of thymidylate synthase (TS). It also inhibits dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyl transferase (GARFT). We reported an intriguing case in which a non-small cell lung cancer patient who was refractory to pretreatment with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment.
KeywordsPemetrexedS-1Thymidylate Synthase
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