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Inhibition of Radiation-Induced Lung Adenocarcinoma Cell Metastasis by Adenovirus of PIAS3 Overexpression Driven by Radiation-Inducible Promoter (<i>Ad-pig3RRP-PIAS3</i>)
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
The Second Artillery General Hospital, Beijing, China
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
Department of Thoracic Surgery, Affiliated Hospital of Military Medical Science Academy of the PLA, Beijing, China
- 1 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 2 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 3 The Second Artillery General Hospital, Beijing, China
- 4 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 5 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 6 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 7 Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, China Centers for Disease Control, Beijing, China
- 8 Department of Thoracic Surgery, Affiliated Hospital of Military Medical Science Academy of the PLA, Beijing, China
Journal of Cancer Therapy·Volume 05 (2014)·Pages 1362–1365·Published 3 December 2014·DOI10.4236/jct.2014.514136
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Abstract
Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT 3 in lung adenocarcinoma cells. Based on the importance role of STAT 3 in cell proliferation and survival, we can construct an adenovirus vector of PIAS 3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT 3 specifically. In this way, when STAT 3 was activated by radiation, the expression of PIAS 3 will be increased at the same time; this lead to the inhibition of invasion and metastasis caused by STAT 3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.
KeywordsRadiationAdenocarcinomaMetastasisPromoter<i>PIAS3</i>
- Ohuchida, K., Mizumoto, K., Murakami, M., Qian, L.-W., Sato, N., Nagai, E., Matsumoto, K., Nakamura, T. and Tanaka, M. (2004) Radiation to Stromal Fibroblasts Increases Invasiveness of Pancrea-Tic Cancer Cells through Tumor-Stromal Interactions. Cancer Research, 64, 3215-3222. http://dx.doi.org/10.1158/0008-5472.CAN-03-2464
- Qian, L.W., Mizumoto, K., Urashima, T., Nagai, E., Maehara, N., Sato, N., Nakajima, M. and Tanaka, M. (2002) Radiation-Induced Increase in Invasive Potential of Human Pancreatic Cancer Cells and Its Blockade by a Matrix Metalloproteinase Inhibitor, CGS27023. Clinical Cancer Research, 8, 1223-1227. http://clincancerres.aacrjournals.org/content /8/4/1223
- Canazza, A., Calatozzolo, C., Fumagalli, L., Bergantin, A., Ghielmetti, F., Fariselli, L., Croci, D., Salmaggi, A. and Ciusani, E. (2011) Increased Migration of a Human Glioma Cell Line after in Vitro CyberKnife Irradiation. Cancer Biology & Therapy, 12, 629-633. http://dx.doi.org/10.4161/cbt.12.7.16862
- Park, C.M., Park, M.J., Kwak, H.J., Lee, H.C., Kim, M.S., Lee, S.H., Park, I.C., Rhee, C.H. and Hong, S.I. (2006) Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor-Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways. Cancer Research, 66, 8511-8519. http://cancerres.aacrjournals.org/content/66/17/8511
- Cheng, J.C., Chou, C., Kuo, M.L. and Hsieh, C.Y. (2006) Radiation-Enhanced Hepatocellular Carcinoma Cell Invasion with MMP-9 Expression through PI3K/Akt/NF-κB Signal Transduction Pathway. Oncogene, 25, 7009-7018. http://dx.doi.org/10.1038/sj.onc.1209706
- Zhang, X., Li, X., Zhang, N., Yang, Q. and Moran, M.S. (2011) Low Doses Ionizing Radiation Enhances the Invasiveness of Breast Cancer Cells by Inducing Epithelial-Mesenchymal Transition. Biochemical and Biophysical Research Communications, 412, 188-192. http://dx.doi.org/10.1016/j.bbrc.2011.07.074
- Kaliski, A., Maggiorella, L., Cengel, K.A., Mathe, D., Rouffiac, V., Opolon, P., Lassau, N., Bourhis, J. and Deutsch, E. (2005) Angiogenesis and Tumor Growth Inhibition by a Matrix Metalloproteinase Inhibitor Targeting Radiation-Induced Invasion. Molecular Cancer Therapeutics, 4, 1717-1728. http://mct.aacrjournals.org/content/4/11/1717
- Guerra, L.E., Smith, R.M., Kaminski, A., Lagios, M.D. and Silverstein, M.J. (2008) Invasive Local Recurrence Increased after Radiation Therapy for Ductal Carcinoma in Situ. The American Journal of Surgery, 196, 552-555. http://dx.doi.org/10.1016/j.amjsurg.2008.06.008