Research ArticleOpen AccessGoogle Scholar indexed
Is Use of Radiation Hormesis the Missing Link to a Better Cancer Treatment?
Private Practice, Innovative Spine & Wellness, Newmarket, Canada
- 1 Private Practice, Innovative Spine & Wellness, Newmarket, Canada
Journal of Cancer Therapy·Volume 06 (2015)·Pages 601–605·Published 7 July 2015·DOI10.4236/jct.2015.67065
Copy link · social · email
Abstract
Radiation hormesis is a concept that pervades radiobiological exposures; low doses enhance immune response, while higher doses inhibit immune response. Low-dose Total-Body Irradiation (TBI) therapy offers radiation treatment to cancer patients using the concepts of radiation hormesis and show very good success rates. This phenomenon has been reported elsewhere as the “abscopal effect” and considering the marginal success rates of other treatment agents, like the immunotherapy drug Ipilimumab, TBI therapy may prove to be the missing link to a better cancer treatment.
KeywordsCancerRadiation HormesisAbscopal EffectTherapy
- Luckey, T.D. (1980) Hormesis with Ionizing Radiation. CRC Press, Boca Raton.
- Doss, M. (2013) Linear No-Threshold Model vs. Radiation Hormesis. Dose-Response, 11, 495-512. http://dx.doi.org/10.2203/dose-response.13-005.Doss
- Cuttler, J.M. (2013) Commentary on Fukushima and Beneficial Effects of Low Radiation. Dose-Response, 11, 447-458. http://dx.doi.org/10.2203/dose-response.13-008.Cuttler
- Feinendegen, L.E., Pollycove, M. and Neumann, R.D. (2013) Hormesis by Low Dose Radiation Effects: Low Dose Cancer Risk Modeling Must Recognize Up-Regulation of Protection. In: Baum, R.P., Ed., Therapeutic Nuclear Medicine, Springer.
- Faguet, G.B. (2005) The War on Cancer: An Anatomy of Failure, a Blueprint for the Future. Springer, Dordrecht.
- Goldstein, I., Madar, S. and Rotter, V. (2012) Cancer Research, a Field on the Verge of a Paradigm Shift? Trends in Molecular Medicine, 18, 299-303. http://dx.doi.org/10.1016/j.molmed.2012.04.002
- Remington, P.L. and Brownson, R.C. (2011) Fifty Years of Progress in Chronic Disease Epidemiology and Control. MMWR Surveill, 60, 70-77.
- Murphy, J.B. and Morton, J.J. (1915) The Effect of Roentgen Rays on the Rate of Growth of Spontaneous Tumors in Mice. The Journal of Experimental Medicine, 22, 800-803. http://dx.doi.org/10.1084/jem.22.6.800
- Pollycove, M. and Feinendegen, L.E. (2000) Cellular and Organism Dose-Response: Biopositive (Health Benefit) Effects. Proceedings of International Symposium on Health Benefits of Low-Dose Radiation—The Science and Medical Applications, Washington DC.
- Cuttler, J.M., Pollycove, M. and Welsh, J.S. (2000) Application of Low Doses of Radiation for Curing Cancer. Canadian Nuclear Society Bulletin, 21, 45-50.
- Chaffey, J.T., Rosenthal, D.S., Moloney, W.C. and Hellman, S. (1976) Total Body Irradiation as Treatment for Lymphosarcoma. International Journal of Radiation Oncology * Biology * Physics, 1, 399-405. http://dx.doi.org/10.1016/0360-3016(76)90004-3
- Choi, N.C., Timothy, A.R., Kaufman, S.D., Carey, R.W. and Aisenberg, A.C. (1979) Low Dose Fractionated Whole Body Irradiation in the Treatment of Advanced Non-Hodgkin’s Lymphoma. Cancer, 43, 1636-1642. http://dx.doi.org/10.1002/1097-0142(197905)43:5 3.0.CO;2-E
- Sakamoto, K., Myogin, M., Hosoi, Y., Ogawa, Y., Nemoto, K., Takai, Y., Kakuto, Y., Yamada, S. and Watabe, M. (1997) Fundamental and Clinical Studies on Cancer Control with Total or Upper Half Body Irradiation. JASTRO Japanese Society for Therapeutic Radiology and Oncology, 9, 161-175.