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Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives
Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
Nalanda Institute of Pharmaceutical Sciences, Sattenapalli, Guntur, India
Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
- 1 Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
- 2 Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
- 3 Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
- 4 Nalanda Institute of Pharmaceutical Sciences, Sattenapalli, Guntur, India
- 5 Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
- 6 Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, India
Journal of Cancer Therapy·Volume 06 (2015)·Pages 917–931·Published 4 September 2015·DOI10.4236/jct.2015.610100
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Abstract
According to WHO, cancer is a leading cause of death worldwide, accounting for 8.2 million deaths in 2012. Among several factors involved in the pathogenesis of cancer, free radical formation followed by damage to DNA and cell protein is one of the causes. Natural plant products have gained enormous interest in the prevention or treatment of chronic diseases. Ferulic acid, like other phenolic acids (caffeic acid, sinapic acid) possess anti cancer activity. A series of ferulic esters (FE1 - FE11) and ferulic amides (FA1 - FA10) were synthesized and evaluated for their cytotoxic activity.
KeywordsFerulic AcidCytotoxicityHela (Cervical Cancer Cell Lines)A549 (Lung Cancer Cell Lines)HT-29 (Colorectal Cancer Cell Lines)Synthesis
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