A Retrospective Study of the Treatment Results & Patterns of Failure of Type II Endometrial Cancer Patients Treated at Radiotherapy Department, NCI, Cairo University during the Period from January 2000 till December 2012
- 1 Radiation Oncology department, National Cancer Institute, Cairo University, Giza, Egypt
- 2 Radiation Oncology department, National Cancer Institute, Cairo University, Giza, Egypt
- 3 Clinical Oncology Department, Faculty of Medicine, Cairo University, Giza, Egypt
- 4 Radiation Oncology department, National Cancer Institute, Cairo University, Giza, Egypt
Abstract
Aim of the study: To identify all clinico-pathological data, different treatment modalities and the different prognostic factors which affected the locoregional control (LC), disease-free survival (DFS), and overall survival (OS) of Type II endometrial cancer patients. Patients and methods: Data of Type II endometrial carcinoma patients who presented to the Radiation Oncology department, National Cancer Institute, Cairo University during the period from (2000-2012) were retrospectively reviewed. Results: Multivariate analysis identified stage as an independent prognostic factor for OS & DFS, and age was an independent prognostic factor for DFS and LC. Low pretreatment hemoglobin levels significantly affected OS. Conclusion: Large and multicentric clinical trials are required to further study this group of patients and define optimum treatment modalities.
- Global Cancer Atlas-Globocan-2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx
- Albertini, A.F., Devouassoux-Shisheboran, M., Genestie, C., et al. (2012) Pathology of Endometrioid Carcinoma. Bull Cancer, 99, 7-12.
- Hamilton, C.A., Cheung, M.K., Osann, K., Chen, L., Teng, N.N., Longacre, T.A., et al. (2006) Uterine Papillary Serous and Clear Cell Carcinomas Predict for Poorer Survival Compared to Grade 3 Endometrioid Corpus Cancers. British Journal of Cancer, 94, 642-646. http://dx.doi.org/10.1038/sj.bjc.6603012
- Mendivil, A., Schuler, K.M. and Gehrig, P.A. (2009) Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes. Cancer Control, 16, 46-52.
- Dunton, C.J., Balsara, G., McFarland, M. and Hernandez, E. (1991) Uterine Papillary Serous Carcinoma: A Review. Obstetrical & Gynecological Survey, 46, 97-102. http://dx.doi.org/10.1097/00006254-199102000-00014
- Fader, A.N., Starks, D., Gehrig, P.A., Secord, A.A., Frasure, H.E., O’Malley, D.M., et al. (2009) An Updated Clinicopathologic Study of Early-Stage Uterine Papillary Serous Carcinoma (UPSC). Gynecological Oncology, 115, 244-248. http://dx.doi.org/10.1016/j.ygyno.2009.07.030
- Hamilton, C.A., Cheung, M.K., Osann, K., Chen, L., Teng, N.N., Longacre, T.A., et al. (2006) Uterine Papillary Serous and Clear Cell Carcinomas Predict for Poorer Survival Compared to Grade 3 Endometrioid Corpus Cancers. British Journal of Cancer, 94, 642-646. http://dx.doi.org/10.1038/sj.bjc.6603012
- Cirisano Jr., F.D., Robboy, S.J., Dodge, R.K., Bentley, R.C., Krigman, H.R., Synan, I.S., et al. (1999) Epidemiologic and Surgicopathologic Findings of Papillary Serous and Clear Cell Endometrial Cancers When Compared to Endometrioid Carcinoma. Gynecologic Oncology, 74, 385-394. http://dx.doi.org/10.1006/gyno.1999.5505
- Petignat, P., Usel, M., Gauthier, P., Popowski, Y., Pelte, M.F., Bouchardy, C., et al. (2008) Outcome of Uterine Clear Cell Carcinomas Compared to Endometrioid Carcinomas and Poorly-Differentiated Endometrioid Carcinomas. European Journal of Gynaecological Oncology, 29, 57-60.
- Sagr, E.R., Denschlag, D., Kerim-Dikeni, A., Stanimir, G., Gitsch, G. and Gilbert, L. (2007) Prognostic Factors and Treatment-Related Outcome in Patients with Uterine Papillary Serous Carcinoma. Anti-Cancer Research, 27, 1213-1217.
- Boruta 2nd, D.M., Gehrig, P.A., Fader, A.N., Olawaiye, A.B., et al. (2009) Management of Women with Uterine Papillary Serous Cancer: A Society of Gynecologic Oncology (SGO) Review. Gynecologic Oncology, 115, 142-153. http://dx.doi.org/10.1016/j.ygyno.2009.06.011