Expression and Significance of IL-6 and bFGF in Human Tongue Squamous Cell Carcinoma
- 1 Department of Pathology, Yiyang Medical University, Yiyang, China
- 2 Respiratory Medicine of Yiyang Central Hospital, Yiyang, China
- 3 School of Foreign Languages, Henan University of Technology, Zhengzhou, China
- 4 Department of Pathology, Yiyang Medical University, Yiyang, China
- 5 Department of Pathology, Yiyang Medical University, Yiyang, China
- 6 Department of Pathology, Yiyang Medical University, Yiyang, China
Abstract
Objective: To detect the expression and pathological significances of Interleukin-6 (IL-6) and basic fibroblast growth factor (bFGF) in tongue squamous cell carcinoma (TSCC). Methods: A tissue array was analyzed immunohistochemically. The expression levels of IL-6 and bFGF in tissues were recorded semi-quantitatively. Results: The positive expression of IL-6 in normal, benign tumor, and carcinoma groups was 12.50% ± 5.575%, 39.00% ± 1.41%, 77.26% ± 17.07% respectively, and the expression among the three groups showed significant differences ( P < 0.05). The expression of bFGF in benign tumor was lower than that in normal groups and squamous cell carcinoma. The positive expression was 6.50% ± 2.12%, 23.75% ± 4.79%, 42.33% ± 29.89% respectively, and the expression among the three groups showed significant differences ( P < 0.05). Furthermore, there were positive correlations between IL-6 and bFGF ( P < 0.05). Conclusion: It indicates that combining immunohistochemical examination of IL-6 and bFGF has an important reference value on the pathological diagnosis of tongue squamous cell carcinoma.
- Weinberg, M.A. and Estefan, D.J. (2002) Assessing Oral Malignancies. American Family Physician, 65, 1379-1384.
- Mehrotra, R., Gupta, A., Singh, M., et al. (2006) Application of Cytology and Molecular Biology in Diagnosing Remalignant or Malignant Oral Lesions. Molecular Cancer, 5, 11. https://doi.org/10.1186/1476-4598-5-11
- Komolmalai, N., Chuachamsai, S., Tantiwipawin, S., et al. (2015) Ten-Year Analysis of Oral Cancer Focusing on Young People in Northern Thailand. Journal of Oral Science, 57, 327-334. https://doi.org/10.2334/josnusd.57.327
- Di Bella, L.M., Alampi, R., Biundo, F., et al. (2017) Copper Chelation and Interleukin-6 Proinflammatory Cytokine Effects on Expression of Different Proteins Involved in Iron Metabolism in HepG2 Cell Line. BMC Biochemistry, 18, 1-11. https://doi.org/10.1186/s12858-017-0076-2
- Hou, J.-H., Liu, Y.-Y., Li, C., Deng, S.-H. and Liu, B.-Y. (2015) Effects of Buyang Huanwu Decoction on Cyclin D1 and Cdk2 of Post-Stroke Depression in Rats. Chinese Journal of Behavioral Medicine and Brain Science, 24, 680-683.
- Koo, K., Barrowman, R., McCullough, M., et al. (2013) Non-Smoking Non-Drinking Elderly Females: A Clinically Distinct Subgroup of Oral Squamous Cell Carcinoma Patients. International Journal of Oral & Maxillofacial Surgery, 42, 929-933. https://doi.org/10.1016/j.ijom.2013.04.010
- Huang, J., Hou, J.-H., Wang, G.-H., et al. (2012) Effect of HMBA on Proliferation and Expression of KLF6 and Related Proteins in Human Tongue Carcinoma Tca8113 Cells. Chinese Journal of Pathophysiology, 28, 433-438.
- Franz, M., Spiegel, K., Umbreit, C., et al. (2009) Expression of Snail Is Associated with Myofibroblast Phenotype Development in Oral Squamous Cell Carcinoma. Histochemistry and Cell Biology, 131, 651-660. https://doi.org/10.1007/s00418-009-0559-3
- Goymer, P. (2008) Natural Selection: The Evolution of Cancer. Nature, 454, 1046-1048. https://doi.org/10.1038/4541046a
- Rossle, M., Weber, C.S., Zullig, L., et al. (2013) EGFR Expression and Copy Number Changes in Low T-Stage Oral Squamous Cell Carcinomas. Histopathology, 10, Article ID: 12175. https://doi.org/10.1111/his.12175
- Migita, K., Izumi, Y., Jiuchi, Y., et al. (2014) Effects of Janus Kinase Inhibitor Tofacitinib on Circulating Serum Amyloid A and Interleukin-6 during Treatment for Rheumatoid Arthritis. Clinical & Experimental Immunology, 175, 208-214. https://doi.org/10.1111/cei.12234