Pancreatic Gastrointestinal Stromal Tumour: A Case Report and Review of the Literature
- 1 Department of Medical Imaging, Ibn Al Jazzar University Hospital, Kairouan, Tunisia
- 2 Department of Digestive Surgery, Sahloul University Hospital, Sousse, Tunisia
- 3 Department of Digestive Surgery, Sahloul University Hospital, Sousse, Tunisia
- 4 Department of Digestive Surgery, Sahloul University Hospital, Sousse, Tunisia
- 5 Department of Digestive Surgery, Sahloul University Hospital, Sousse, Tunisia
- 6 Department of Digestive Surgery, Sahloul University Hospital, Sousse, Tunisia
Abstract
Gastrointestinal stromal tumours (GIST) are rare mesenchymal neoplasms that can develop in the entire length of the gastrointestinal tract or sometimes from the omentum and mesentery. In most cases, they arise from the stom ach, less often the jejunum or ileum. We report the case of a 53-year-old-female patient, without significant medical history, consulting for chronic epigastric pain, with no other associated signs. She had underwent an abdominal ultrasound completed with a Contrast-enhanced computed tomography (CT) of the abdomen showing a large tissular mass developed at the expense of the cephalic portion of the pancreas, with central calcifications and heterogeneous enhancement after contrast injection. Pancreaticoduodenectomy, partial colectomy and antrectomy has been performed and histological examination with immunohistochemical study had concluded the diagnosis of pancreatic primary GIST.
- Yan, B.M., Pai, R.K. and Van Dam, J. (2008) Diagnosis of Pancreatic Gastrointestinal Stromaletumor by EUS Guided FNA. JOP, 9, 192-196.
- Mazur, M.T. and Clark, H.B. (1983) Gastric Stromaletumors. Reappraisal of Histogenesis. The American Journal of Surgical Pathology, 7, 507-519. https://doi.org/10.1097/00000478-198309000-00001
- Bassou, D., Darbi, A., Harket, A., Chamssi, M., et al. (2008) Tumeur Stromale Digestive: Apport du scanner et corrélations pathologiques. Feuillets de Radiologie, 48, 39-44. https://doi.org/10.1016/S0181-9801(08)70318-X
- Landi, B., Lecomte, T., Berger, A. and Cellier, C. (2004) Clinical Management of Gastrointestinal Stromal Tumors. Gastroenterologie Clinique et Biologique, 28, 893-901. https://doi.org/10.1016/S0399-8320(04)95154-8
- Handra-Luca, A., Nahon, P., Fléjou, J.F., Molas, G, et al. (2001) Immunohistochemical and Ultrastructural Heterogeneity of Gastrointestinal Stromal Tumors. Gastroenterologie Clinique Et Biologique, 25, 664-668.
- Montemurroa, M., Dirnhoferb, S. and Bornerc, M. (2008) Recommendations for the Diagnosis, Treatment, and Monitoring of Patients with Gastrointestinal Stromal Tumor. Forum Médical Suisse, 8, 544-549.
- De Mestier, Ph. and des Guetz, G. (2003) Treatment of Gastrointestinal Stromal Tumors with Imatinib: A Major Breakthrough in the Understanding of the Tumor-Specific Molecular Characteristics. E-Mémoires de l’AcadémieNationale de Chirurgie, 2, 48-52.
- Lau, S., Tama, K.F., Kama, C.K., Luia, C.Y., et al. (2004) Imaging of Gastrointestinal Stromale Tumour (GIST). Clinical Radiology, 59, 487-498. https://doi.org/10.1016/j.crad.2003.10.018
- Taieb, S., Ceugnart, L., Bonodeau, F., Vanseymortier, L., et al. (2008) GIST: Imaging Findings. Journal De Chirurgie, 145, 6S12–6S17.
- Blay, J.Y., Landi, B., Bonvalot, S., Monges, G., et al. (2005) Recommendations for the Management of GIST Patients. Bulletin du Cancer, 92, 907-918.
- Daum, O., Klecka, J., Ferda, J., Treska, V., et al. (2005) Gastrointestinal Stromaletumor of the Pancreas: Case Report with Documentation of KIT Gene Mutation. Virchows Archiv, 446, 470-472. https://doi.org/10.1007/s00428-004-1200-4
- Harindhanavudhi, T., Tanawuttiwat, T., Pyle, J. and Silva, R. (2009) Extra-Gastrointestinal Stromal Tumor Presenting as Hemorrhagic Pancreatic Cyst Diagnosed by EUS-FNA. Journal of the Pancreas, 10, 189-191.