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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En…
Maria Maiello, Rakesh K. Sharma, Marco Matteo Ciccone, Humananth K. Reddy, Pasquale Palmiero
Background: breast cancer because of radiotherapy and/or chemotherapy causes cardiac disease, often it occurs on women just affected by hypertension and/or diabetes. All these conditions may affect left ventricular (LV) geometry, mass and diastolic function.…
Riccardo Lencioni, James Chen, Gordon Downie, Llew Keltner
Lung cancer is the leading cause of cancer-related death worldwide. Despite intensive research conducted during the past years, little improvement in overall survival has been achieved for patients with advanced disease. Chemotherapy and radiation continue to…
Karina Dahl Steffensen, Marianne Waldstrøm, Anders Jakobsen
Objectives: Excision repair cross-complementation group 1 (ERCC1) is a key DNA repair gene in the nucleotide excision repair pathway which is activated in the repair of intra- and interstrand DNA crosslink caused by platinum-based treatment. Two single nucleo…
Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki, Itaru Yasufuku, Ryuichi Asai, Yoshihisa Tokumaru, Takuji Sakuratani, Kazuhiro Yoshida
Among the ablation procedures used against advanced liver cancer, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized. In contrast, the principle of cryosurgery is not only to control local re…
Zafar Iqbal, Fatima Manzoor, Mudassar Iqbal, Shahid Ali, Nadeem Sheikh, Mahwish Khan, Aamer Aleem, Tanveer Akhtar
BCR-ABL fusion oncogene originates from the reciprocal translocation of chromosome 9 and 22 t(9;22) (q34;q11). It translates a chimeric protein, p210, characterized by constitutive activation of its tyrosine kinase, which triggers leukemogenic pathways result…
Tomohiro Osaki, Motoshi Tajima, Yoshiharu Okamoto, Satoshi Takagi, Takeshi Tsuka, Tomohiro Imagawa, Saburo Minami
Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cell…
King-Fai Cheng, Ping-Chung Leung
Background: Cancer has become a leading cause of death world-wide. In Hong Kong, cancer accounted for 24.8% of deaths in 1980, rising to 31.3% in 1998. The conventional treatment of cancer usually includes surgery, radiotherapy and chemotherapy. These convent…
Cody P. Coyne, Toni Jones, Andrzej Sygula, John Bailey, Lesya Pinchuk
Purpose: Discover the anti-neoplastic efficacy of epirubicin-(C13-imino)-[anti-HER2/neu] against chemotherapeutic- resistant SKBr-3 mammary carcinoma and delineate the capacity of selenium to enhance it’s cytotoxic anti-neoplastic potency. Methods: In molar e…
Mehdi Hedayati, Razieh Yazdanparast, Marjan Zarif Yeganeh, Laleh Hoghooghi Rad, Fereidoun Azizi
Background: Daphne Mucronata extract has a decreasing effect on the size of breast adenocarcinoma in rats. So in this study, the effect of Daphne Mucronata purified diterpene were investigated on co culture of human monocytes and two human leukemia cell lines…
Bahire Küçükkaya, Lale Afrasyap
This study investigated contents of trace elements selenium, zinc and iron both in control K562 cells, human leukemia cell line, and cells treated with hemin or the iron chelator deferoxamine cells. K562 cell line was grown in RPMI medium supplemented with 10…
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JCT is an international journal dedicated to the latest advancements in cancer therapy. The goal of this journal is to provide a platform for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in cancer related problems. All manuscripts must be prepared in En… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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