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Adrenocortical system activity in alloxan-resistant and alloxan-susceptible Wistar rats
Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
- 1 Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
- 2 Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
- 3 Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia
Journal of Diabetes Mellitus·Volume 02 (2012)·Pages 165–169·Published 25 May 2012·DOI10.4236/jdm.2012.22026
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Abstract
In the dynamics of the disease development, diuresis and glycosuria increase in alloxan-susceptible rats, while in alloxan-resistant rats the increase in the values of these indices is expressed to a lesser extent, and they begin to decrease by day 8 of the disease. In alloxan-susceptible rats, the mass index of adrenal gland is increased, and that of thymus is decreased and corticosterone concentration in blood, adrenal gland and urine as well as alanine and aspartate aminotransferase activities in liver are increased; in alloxan-resistant rats the values of these indices do not differ from those of rats of the control group.
KeywordsExperimental DiabetesAlloxan-Resistant and Alloxan-Susceptible RatsAdrenocortical System ActivityCorticosteroids Concentration in Urine
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