Visfatin levels are low in subjects with type 2 diabetes compared to age-matched controls
- 1 Department of Medicine, Stratton VA Medical Center/AMC, Albany, USA
- 2 Department of Research, Overton Brooks VA Medical Center, Shreveport, USA
- 3 Department of Research, Overton Brooks VA Medical Center, Shreveport, USA
- 4 Louisiana State University Health Sciences Center, Shreveport, USA
- 5 Overton Brooks VA Medical Center/LSUHSC, Shreveport, USA
- 6 Louisiana State University Health Sciences Center, Shreveport, USA
Abstract
Background: Visceral adiposity correlates strongly with insulin resistance and components of metabolic syndrome. Visfatin is preferentially produced by human visceral adipose tissue. Objective: The objective of this study was to evaluate the relationship between circulating levels of visfatin and other adipocytokines in patients with type 2 diabetes (DM) compared to the age-matched control subjects without DM. Methods: Anthropometric parameters, lipid profiles, high-sensitivity CRP (hs-CRP), insulin resistance [HOMA-IR], and levels of visfatin, TNF-α, and resistin were evaluated in 55 subjects with diabetes and 56 age matched control subjects without diabetes. Results: The visfatin levels were significantly lower in subjects with diabetes (p < 0.0001). Visfatin levels correlated strongly with resistin and CRP. We noted negative correlation of visfatin levels with BMI, triglycerides and glucose. Conclusion: These data suggest that visfatin may be a marker of subclinical inflammatory state.
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