Comparative Study between the Effect of <i>Momordica charantia</i> (Wild Type) Fruits and <i>Coccinia cordifolia</i>’s Leaf on Hypoglycemic and Hypolipidemic Activities of Alloxan

Abstract

Aims: The study was aimed to compare the hypoglycemic and hypolipidemic effect of Momordica charantia (wild type) fruits and Coccinia cordifolia ’s leaf in alloxan induced type 2 diabetic Long-Evans rats. Methods: All rats were divided into groups A to H (n = 48, 06 rats per group). They were made diabetic by intraperitoneally injecting alloxan monohydrate 150-mg/Kg-body weight. Groups A and B were provided with normal diet and glibenclamide plus normal diet respectively. C to H groups were provided with different percentages (70%, 50% and 30% of regular diet) of samples. Different biochemical parameters (blood glucose level, serum total cholesterol, triglyceride (TG), LDL, HDL, serum insulin, hepatic glycogen) were observed for 21 consecutive days (at eight days interval). Results: Oral administration of both of the Momordica charantia (wild type) fruits and Coccinia cordifolia ’s leaf significantly ( p < 0.05) improved hypoglycemic status by decreasing fasting blood glucose level. Hypolipidemic status also observed, and found improved sig nificantly ( p < 0.05) by decreasing the level of serum total cholesterol, triglyceride (TG), serum insulin level and LDL in type 2 diabetic rats. HDL levels were increased slightly and hepatic glycogen level was more or less unchanged in both groups at 22nd day. Conclusion: Though both samples show hypoglycemic and hypolipidemic activities, 50% wild type fruits of Momordica charantia were more significant ( p < 0.05) to ameliorate the diabetic state in type 2 diabetic Long-Evans rats.