Helicobacter Pylori Infection Is Associated with Dyslipidemia and Increased Levels of Oxidized LDL in Type-2 Diabetes Mellitus

Abstract

Em erging data now indicate and address the strong relationship between H. pylori infection and the incidence of Type 2 DM, a growing body of evidence suggests that the infection with H. pylori may be associated with insulin resistance, chronic inflammation, long-term diabetes complications, and cardiovascular risk factors. The present study was conducted to evaluate the relationship between the infection with Helicobacter pylori and disturbance in Lipid profile in Type 2 Diabetic patients. One hundred and five participants were enrolled, categorized into two groups of H. pylori positive cases and negative controls according to their results of H. pylori IgG antibodies. Subjects in both groups fill the structured questionnaire. Blood samples were drawn for measuring the FBS, 2hr-PP blood sugar, HbA1c, Lipid profile and oxidized LDL. The obtained results were statistically analyzed. The study methodology was approved by the Biomedical Ethics Committee in the Faculty of Medicine, Umm Al-Qura University, Makkah, KSA. 48 cases (45.7%) were diagnosed as H. pylori seropositive and 57 (54.3%) were negative. There is no significant difference in the mean age or mean BMI between the H. pylori negative and positive cases. Glycemic control was similar in the two groups. Total Cholesterol was higher in cases of positive H. pylori compared to negative controls (P < 0.001) and Triglycerides was significantly elevated too (P < 0.005). No significant difference in the levels of HDL-Cholesterol between the two groups, while the mean LDL-Cholesterol was found to be significantly increased in cases of H. pylori positive compared to negative controls (P < 0.001). Oxidized LDL levels in the positive cases was found to be increased significantly (P = 0.001) compared to negative controls. Infection with H. pylori is associated with increased levels of Total Cholesterol, Triglycerides, LDL-C and oxidized LDL in Type 2 Diabetic patie nts.