Evaluation of the Serum Levels of IL-1 in Type 2 Diabetic Patients with and without Diabetic Nephropathy
- 1 Internal Medicine, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
- 2 Infectious Disease, Sari Branch, Islamic Azad University, Sari, Iran
- 3 Pathology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Abstract
Background : Diabetic nephropathy (DN) has been regarded as an important cause of morbidity in patients with type 2 diabetes (T2D). Immune system components are modulated during T2D, with the most apparent modifications in adipose tissue, pancreatic islets, liver, and circulating leukocytes. The aim of this survey was to evaluate the role of IL-1 in the etiopathogenesis of nephropathic T2D. Methods : In this case-control investigation, the study population consisted of 58 T2D patients with proteinuria (nephropath y T2D cases) as the case group and 76 T2D cases without proteinuria (non-nephropath y T2D cases) as the control group. Blood samples were obtained from all individuals and ELISA approach was carried out to measure IL-1 levels in samples. Results : Our experiments demonstrated that T2D patients with nephropathy had significantly increased levels of IL-1 in their blood in comparison to T2D patients without nephropathy. Conclusions : It seems that IL-1 plays a role in the etiopathogenesis of nephropathy in T2D patients, requiring further implementation to vivid disclose of the inflammation in this context.
- Levey, A.S., Coresh, J., Balk, E., Kausz, A.T., Levin, A., Steffes, M.W., et al. (2003) National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Annals of Internal Medicine, 139, 137-147. https://doi.org/10.7326/0003-4819-139-2-200307150-00013
- Foley, R.N. and Collins, A.J. (2007) End-Stage Renal Disease in the United States: An Update from the United States Renal Data System. Journal of the American Society of Nephrology, 18, 2644-2648. https://doi.org/10.1681/ASN.2007020220
- Rosario, R.F. and Wesson, D.E. (2006) Primary Hypertension and Nephropathy. Current Opinion in Nephrology and Hypertension, 15, 130-134. https://doi.org/10.1097/01.mnh.0000214771.88737.ee
- Verma, M.K., Kumar, P., Sharma, P., Singh, V. and Singh, S.P. (2017) Study of Microalbuminuria as Early Risk Marker of Nephropathy in Type 2 Diabetic Subjects. International Journal of Research in Medical Sciences, 5, 3161-3166. https://doi.org/10.18203/2320-6012.ijrms20173006
- Hovind, P., Tarnow, L., Rossing, P., Graae, M., Torp, I., Binder, C., et al. (2004) Predictors for the Development of Microalbuminuria and Macroalbuminuria in Patients with Type 1 Diabetes: Inception Cohort Study. BMJ, 328, 1105. https://doi.org/10.1136/bmj.38070.450891.FE
- Adler, A.I., Stevens, R.J., Manley, S.E., Bilous, R.W., Cull, C.A., Holman, R.R., et al. (2003) Development and Progression of Nephropathy in Type 2 Diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney International, 63, 225-232. https://doi.org/10.1046/j.1523-1755.2003.00712.x
- Bate, K.L. and Jerums, G. (2003) 3: Preventing Complications of Diabetes. Medical Journal of Australia, 179, 498-505.
- Donath, M.Y. and Shoelson, S.E. (2011) Type 2 Diabetes as an Inflammatory Disease. Nature Reviews Immunology, 11, 98-107. https://doi.org/10.1038/nri2925
- Hotamisligil, G.S. (2006) Inflammation and Metabolic Disorders. Nature, 444, 860-867. https://doi.org/10.1038/nature05485
- Steel, D.M. and Whitehead, A.S. (1994) The Major Acute Phase Reactants: C-Reactive Protein, Serum Amyloid P Component and Serum Amyloid A Protein. Immunology today, 15, 81-88. https://doi.org/10.1016/0167-5699(94)90138-4
- Strowig, T., Henao-Mejia, J., Elinav, E. and Flavell, R. (2012) Inflammasomes in Health and Disease. Nature, 481, 278-286. https://doi.org/10.1038/nature10759
- Navarro-González, J.F. and Mora-Fernández, C. (2008) The Role of Inflammatory Cytokines in Diabetic Nephropathy. Journal of the American Society of Nephrology, 19, 433-442. https://doi.org/10.1681/ASN.2007091048