One of the primary problems in the United States is diabetes. Cortex Lycii is an herb from Asia mostly used in traditional Chinese medicine. Although its main purpose is not for lowering blood glucose levels, there are studies on Cortex Lycii with other substances which have proven it can lower glucose level in type 2 diabetes rat. Unlike other experiments, this experiment only used Cortex Lycii as a single unit to see if there was any effect on blood glucose level. Also an observation was done on if Cortex Lycii could reduce blood glucose level after ingesting a high glucose diet. Rattus norvegicus w as used in this project and in order for the subject to consume Cortex Lycii, the herb was boiled and the liquid was given for consumption. In order to increase the rats’ glucose levels, corn syrup and white sugar w ere added to the mixture. The data showed significant decrease of blood glucose when Cortex Lycii liquid was ingested. This research has shown that Cortex Lycii can be a potential treatment for hyperglycemia or diabetes. With further research , there can be an alternative treatment rather than injecting external hormones (Insulin).
Chan, J.Y., Lam, F., Leung, P., Che, C. and Fung, K. (2008) Antihyperglycemic and Antioxidative Effects of a Herbal Formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a Mouse Model of Type 2 Diabetes Mellitus. Phototherapy Research, 23, 658-665. http://onlinelibrary.wiley.com/doi/10.1002/ptr.2694/full
National Diabetes Statistics Report, 2017. (2017) https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf
Mokdad, A.H., Bowman, B.A., Ford, E.S., Vinicor, F., Marks, J.S. and Koplan, J.P. (2001) The Continuing Epidemics of Obesity and Diabetes in the United States. JAMA, 286, 1195-1200. https://doi.org/10.1001/jama.286.10.1195
Lee, I.M., Shiroma, E.J., Lobelo, F., Puska, P., Blair, S.N., Katzmarzyk, P.T., Lancet Physical Activity Series Working Group. (2012) Effect of Physical Inactivity on Major Non-Communicable Diseases Worldwide: An Analysis of Burden of Disease and Life Expectancy. Lancet, 38, 219-229. https://www.ncbi.nlm.nih.gov/pubmed/22818936
Tuomi, T. (2005) Type 1 and Type 2 Diabetes. http://diabetes.diabetesjournals.org/content/54/suppl_2/S40
Vijan, S. (2010) Type 2 Diabetes. http://annals.org/aim/article-abstract/745650/type-2-diabetes
Garvey, W.T., Olefsky, J.M., Griffin, J., Hamman, R.F. and Kolterman, O.G. (1985) The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus. Diabetes, 34, 222-234. http://diabetes.diabetesjournals.org/content/34/3/222.short
Kasuga, M. (2006) Insulin Resistance and Pancreatic β Cell Failure. Journal of Clinical Investigation, 116, 1756-1760. https://doi.org/10.1172/JCI29189
Ghorbani, A. (2014) Clinical and Experimental Studies on Polyherbal Formulations for Diabetes: Current Status and Future Prospective. Journal of Integrative Medicine, 12, 336-345. http://www.sciencedirect.com/science/article/pii/S2095496414600315?via%3Dihub
Gao, J., Liu, Z.J., Chen, T. and Zhao, D. (2014) Pharmaceutical Properties of Calycosin, the Major Bioactive Isoflavonoid in the Dry Root Extract of Radix astragali. Pharmaceutical Biology, 52, 1217-1222. http://www.tandfonline.com/doi/full/10.3109/13880209.2013.879188
Su, K., Zhu, F., Guo, L., Zhu, Y., Li, W. and Xiong, X. (2013) Retrospective Study on Professor Zhongying Zhou’s Experience in Traditional Chinese Medicine Treatment on Diabetic Nephropathy. Journal of Traditional Chinese Medicine, 33, 262-267. http://www.sciencedirect.com/science/article/pii/S0254627213601375?via%3Dihub
Yahara, S., Shigeyama, C., Nohara, T., Okuda, H., Wakamatsu, K. and Yasuhara, T. (1989) Structures of Anti-Ace and -Renin Peptides from Lyciiradicis Cortex. Tetrahedron Letters, 30, 6041-6042. http://www.sciencedirect.com/science/article/pii/S0040403901938493
Li, Y., Hu, S., Huang, Y., Han, Y. and Cheung, H. (2015) Preventing H2O2-Induced Toxicity in Primary Cerebellar Granule Neurons via Activating the PI3-K/Akt/ GSK3β Pathway by Kukoamine from Lycii Cortex. Journal of Functional Foods, 17, 709-721. http://www.sciencedirect.com/science/article/pii/S1756464615003230#
Liu, X., Zheng, X., Long, Y., Cao, H., Wang, N., Lu, Y., et al. (2011) Dual Targets Guided Screening and Isolation of Kukoamine B as a Novel Natural Anti-Sepsis Agent from Traditional Chinese Herb Cortex Lycii. International Immunopharmacology, 11, 110-120. http://www.sciencedirect.com/science/article/pii/S1567576910003449
Yusuf, S., et al. (2000) Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients. New England Journal of Medicine, 342, 145-153.
Tomkin, G.H. (2010) Atherosclerosis, Diabetes and Lipoproteins. Expert Review of Cardiovascular Therapy, 8, 1015-1029. https://doi.org/10.1586/erc.10.45 http://www.tandfonline.com/doi/abs/10.1586/erc.10.45
Chan, J.Y., Koon, J.C., Leung, P., Che, C. and Fung, K. (2011) Suppression of Low-Density Lipoprotein Oxidation, Vascular Smooth Muscle Cell Proliferation and Migration by a Herbal Extract of Radix astragali, Radix codonopsis and Cortex lycii. BMC Complementary and Alternative Medicine, 11, 32. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-32 https://doi.org/10.1186/1472-6882-11-32
He, K., Li, X., Chen, X., Ye, X., Huang, J., Jin, Y. and Shu, H. (2011) Evaluation of Antidiabetic Potential of Selected Traditional Chinese Medicines in STZ-Induced Diabetic Mice. Journal of Ethnopharmacology, 137, 1135-1142. http://www.sciencedirect.com/science/article/pii/S0378874111005095?via%3Dihub#fig0025 https://doi.org/10.1016/j.jep.2011.07.033
Tsuneki, H., Ishizuka, M., Wu, J., Sasaoka, T. and Kimura, I. (2004) Effect of Green Tea on Blood Glucose Levels and Serum Proteomic Patterns in Diabetic (db/db) Mice and on Glucose Metabolism in Healthy Humans. BMC Pharmacology, 4, 18. https://bmcpharma.biomedcentral.com/articles/10.1186/1471-2210-4-18 https://doi.org/10.1186/1471-2210-4-18
Yeo, J., Kang, Y., Cho, S. and Jung, M. (2011) Effects of a Multi-Herbal Extract on Type 2 Diabetes. Chinese Medicine, 6, 10. https://doi.org/10.1186/1749-8546-6-10 https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-6-10
Oh, T.W., Kang, S.Y., Kim, K.H., Song, M. and Park, Y. (2013) Anti-Diabetic Effect of Medicinal Plants Used for Lower Wasting-Thirst in Streptozotocin-Induced Diabetic Rats. The Korea Journal of Herbology, 28, 53-60. http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=DHBCBU_2013_v28n5_53 https://doi.org/10.6116/kjh.2013.28.5.53
Chen, K., Peng, W., Hou, C., Chen, C., Chen, H., Kuo, C. and Korivi, M. (2013) Codonopsis javanica Root Extracts Attenuate Hyperinsulinemia and Lipid Peroxidation in Fructose-Fed Insulin Resistant Rats. Journal of Food and Drug Analysis, 21, 347-355. http://www.jfda-online.com/article/S1021-9498(13)00048-3/fulltext https://doi.org/10.1016/j.jfda.2013.08.001
Muruganandan, S., Srinvasan, K., Gupta, S., Gupta, P. and Lal, J. (2005) Effect of Mangiferin on Hyperglycemia and Atherogenicity in Streptozotocin Diabetic Rats. Journal of Ethnopharmacology, 97, 497-501. http://www.sciencedirect.com/science/article/pii/S0378874105000097 https://doi.org/10.1016/j.jep.2004.12.010
Parasuraman, S., Raveendran, R. and Kesavan, R. (2010) Blood Sample Collection in Small Laboratory Animals. Journal of Pharmacology and Pharmacotherapeutics, 1, 87-93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043327/ https://doi.org/10.4103/0976-500X.72350
Lee, G. and Goosens, K.A. (2015) Sampling Blood from the Lateral Tail Vein of the Rat. Journal of Visualized Experiments, No. 99, Article No. 52766. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542852/ https://doi.org/10.3791/52766
Stewart, K. and Schroeder, V.A. (2018) Blood Withdrawal I. https://www.jove.com/science-education/10246/blood-withdrawal-i
Office of Animal Resources Institutional Animal Care and Use Committee (n.d.). https://animal.research.uiowa.edu/iacuc-guidelines-blood-collection
Quesenberry, K.E., Donnelly, T.M. and Mans, C. (2012) Chapter 22 Biology, Husbandry, and Clinical Techniques of Guinea Pigs and Chinchillas. In: Quesenberry, K.E. and Carpenter, J.W., Eds., Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, Elsevier, Amsterdam, 279-294. https://www.sciencedirect.com/science/article/pii/B9781416066217000221 https://doi.org/10.1016/B978-1-4160-6621-7.00022-1
Cortright, R.N., Collins, H.L., Chandler, M.P., Lemon, P.W. and Dicarlo, S.E. (1999) Diabetes Reduces Growth and Body Composition More in Male than in Female Rats. Physiology & Behavior, 60, 1233-1238. http://www.sciencedirect.com/science/article/pii/S0031938496002223 https://doi.org/10.1016/S0031-9384(96)00222-3
Ye, Z., Huang, Q., Ni, H.X. and Wang, D. (2008) Cortex Lycii Radicis Extracts Improve Insulin Resistance and Lipid Metabolism in Obese-Diabetic Rats. Phytotherapy Research, 22, 1665-1670. https://doi.org/10.1002/ptr.2552 http://onlinelibrary.wiley.com/doi/10.1002/ptr.2552/full