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Synthesis and Radiation Dosimetry of [<sup>68</sup>Ga]-Ga-Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology
Cancer Center Cyclotron Department, Doctors Hospital, Monterrey, México
Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, México City, México
Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
- 1 Cancer Center Cyclotron Department, Doctors Hospital, Monterrey, México
- 2 Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
- 3 Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
- 4 Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
- 5 Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, México City, México
- 6 Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
- 7 Departamento de Medicina Nuclear, Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología, México City, México
Journal of Encapsulation and Adsorption Sciences·Volume 10 (2020)·Pages 29–41·Published 18 June 2020·DOI10.4236/jeas.2020.102002
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Abstract
This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys 1 , Lys 3 -DOTA-BBN (1,14) analog with the radiolabeled positron emitter [ 68 Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).
KeywordsRadiation DosimetryBiodistributionPET ImagingRadiopharmaceuticalLys<sup>1</sup>Lys<sup>3</sup>-DOTA-BBN (114)Bombesin Analogs
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