Preparation and Characterization of Poly(β-Amino Ester) Capsules for Slow Release of Bioactive Material

Abstract

Network structures from poly( β -amino ester) (PAE) were synthesized for applying as drug delivery matrix via a simplified addition polymerization method. It can hold an active organic compound (drug) that ha s an effect as antitumor activity in order to control its release. PAE was prepared from piperazine and 1,4-butandiol diacrylate with different molar ratios. The active compound was mixed with the prepared polymer while warming for 15 minutes to obtain the capsule product. The resulting polymer structures and the surface morphology of the PAE capsules before and after encapsulation with the active drug were characterized by FT-IR and SEM, respectively. Swelling and degradation behavior of PAE were studied. The characterization showed that the obtained network structure of PAE depends on the molar ratio between the reactants. The optimum ratio of the reactants was found to be 1:1. Therefore , stable and white product as well as good holding capability for drug produced. The SEM studies illustrate good dispersion and holding properties of the drug into the network structure of the prepared polymer. In vitro , the release results of the drug from the PAE capsules indicated that the capsules were able to give sustained release of drug in DMF up to 10 days at 25°C.