Research ArticleOpen AccessGoogle Scholar indexed
Study of Diffusion through the Skin of Coated L-Ascorbic Acid by Fluid Bed Technology
Biotechnology Research Group, Textile Research Institute (AITEX), Alcoy, Spain
Biotechnology Research Group, Textile Research Institute (AITEX), Alcoy, Spain
- 1 Biotechnology Research Group, Textile Research Institute (AITEX), Alcoy, Spain
- 2 Biotechnology Research Group, Textile Research Institute (AITEX), Alcoy, Spain
Journal of Encapsulation and Adsorption Sciences·Volume 07 (2017)·Pages 75–82·Published 12 June 2017·DOI10.4236/jeas.2017.72005
Copy link · social · email
Abstract
Coating protects substances such as L-ascorbic acid from natural processes like oxidation. In this study, L-ascorbic acid was coated by fluid bed technology. A pH-dependent polymer was used as a coating material in order to release L-ascorbic acid (dissolution above pH 5.5) under conditions closest to the skin’s natural condition. Different techniques were used to determine the coating (SEM and size distribution) and to evaluate the percentage of coated L-ascorbic acid and its diffusion through the skin.
KeywordspH Dependent PolymerL-Acid AscorbicDiffusionFluid Bed
- Telang, P. (2013) Vitamin C in Dermatology. Indian Dermatology Online Journal, 4, 143-146. https://doi.org/10.4103/2229-5178.110593
- Sheraz, M.A., Ahmed, S., Ahmad, I. and Shaikh, RH. (2001) Formulation and Stability of Ascorbic Acid in Topical Preparations. Systematic Reviews in Pharmacy, 2, 86-90. https://doi.org/10.4103/0975-8453.86296
- Smaoui, S., Ben Hlima, H. and Kadri, A. (2013) Application of L-Ascorbic Acid and Its Derivatives (Sodium Ascorbyl Phosphate and Magnesium Ascorbyl Phosphate) in Topical Cosmetic Formulations: Stability Studies. Journal of the Chemical Society of Pakistan, 35, 1096-1102.
- Desai, K.G.H. and Park, H.J. (2005) Recent Developments in Microencapsulation of Food Ingredients. Drying Technology, 23, 1361-1394. https://doi.org/10.1081/DRT-200063478
- Wilson, N. and Shah, N.P. (2007) Microencapsulation of Vitamins. ASEAN Food Journal, 14, 1-14.
- De Souzaa, C. and Siqueiraa, S. (2015) Spray-Drying: Preparacao, caracterizacao e atividade antioxidante. Química Nova, 38, 877-883.
- Ozsagiroglu, E., Avcibasi Guvenilir, Y., et al. (2016) Production of Polycaprolactone-Polyethylene Glycol-Sodium Alginate Biocomposites for Spray Drying Encapsulation of L-Ascorbic Acid. Iranian Polymer Journal, 25, 757-763. https://doi.org/10.1007/s13726-016-0464-2
- Davis, J.L., Paris, H., et al. (2016) Liposomal-Encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect against Ischemia-Reperfusion Injury. Nutrition and Metabolic Insights, 9, 25-30.
- Revuelta, M.V., et al. (2011) AA Encapsulated in Hydrophobic Silica Xerogel. Food Technology and Biotechnology, 49, 347-351.
- Khalida, N. and Kobayashia, I. (2014) Monodisperse W/O/W Emulsions Encapsulating L-Ascorbic Acid: Insights on Their Formulation Using Microchannel Emulsification and Stability Studies. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 458, 69-77.
- Poncelet, D., Prata, A.S. and El Mafadi, S. (2009) Optimisation and Process Control of Fluid Bed Coating. XVIIth International Conference on Bioencapsulation, Netherlands.
- Risch, S.J. and Reineccius, G.A., Eds. (1995) Encapsulation and Controlled Release of Food Ingredients. American Chemical Society, USA. https://doi.org/10.1021/bk-1995-0590
- Hemati, M., Cherif, R., Saleh, K. and Pont, V. (2003) Fluidized Bed Coating and Granulation: Influence of Process-Related Variables and Physicochemical Properties on the Growth Kinetics. Powder Technology, 130, 18-34. https://doi.org/10.1016/S0032-5910(02)00221-8