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Radio Pet Therapy of Healthy Wistar Rats with <sup>64</sup>CuCl<sub>2</sub> Labeled to <sup>64</sup>Cu(AcAc)<sub>2</sub> Supported in Functionalized TiO<sub>2</sub> Nanoparticles
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
Unidad Radiofarmacia-Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, México
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
Departamento de Química, Universidad de Alicante, España
- 1 Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
- 2 Unidad Radiofarmacia-Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, México
- 3 Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
- 4 Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, CdMx, México
- 5 Departamento de Química, Universidad de Alicante, España
Journal of Encapsulation and Adsorption Sciences·Volume 07 (2017)·Pages 121–126·Published 25 September 2017·DOI10.4236/jeas.2017.73009
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Abstract
In recent years Copper-64 in the chemical form of copper chloride ([ 64 Cu]CuCl 2 ) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64 CuCl 2 , the nanoparticles Cu(acac) 2 / F -TiO 2 were mixed with 64 CuCl 2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac) 2 / F -TiO 2 . The “ in vivo ” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.
KeywordsPET TherapyNanoparticlesFunctionalized Titania (<b>F</b>-Tio<sub>2</sub>)Titanium Acetylacetonate [<b>Cu (AcAc)<sub>2</sub></b>
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