In the radio frequency (RF) range concern about long-term health risks from electromagnetic fields (EMF) is enhanced by contradictory results and conclusions from epidemiologic studies. A new approach of a synoptic analysis of all available data from epidemiological studies published since 2001 was performed. This approach provided new insight with regard to a potential link between mobile phone use and brain cancer. Two quite different data pools could be identified with numerous studies from one research group opposing all other studies. However, it could be shown that with the number of exposed cases both data pools exhibit a clear trend of risk estimates (odds ratios) towards the final result, namely a reduced cancer risk of OR = 0.8, though from either side of the zero-risk line. The analysis of potential long-term effects indicated by a dosedependence revealed diverging results with different dose metrics. Overall, the synoptic analysis supports reassuring rather than alarming conclusions on RF EMF health risks from mobile telecommunication.
IARC (2002) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 80. Non-Ionizing Radiation, Part 1: Static and Extremely Low-Frequency (ELF) Electric and Magnetic Fields. IARC, Lyon.
IARC (2011) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 102. Non-Ionizing Radiation, Part 2: Radio Frequency (RF) Electromagnetic Fields. IARC, Lyon.
ICNIRP (1998) Guidelines for Limiting Exposure to Time-Varying Electric, Magnetic and Electromagnetic Fields (Up to 300 GHz). Health Physics, 74, 494-522.
EU (2013) Directive on the Minimum Health and Safety Requirements Regarding Exposure of Workers to the Risks Arising from Physical Agents (Electromagnetic Fields). Official Journal of the European Union, L179, 1-18.
IEEE (2005) IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields (Up to 300 GHz).
Leitgeb, N. (2014) Childhood Leukemia Not Linked with ELF Magnetic Fields. Journal of Electric and Magnetic Analysis and Applications, 6, 174-183.
Hardell, L. and Carlberg, M. (2013) Using the Hill Viewpoints from 1965 for Evaluating Strengths of Evidence of the Risk for Brain Tumors Associated with the Use of Mobile and Cordless Phones. Reviews on Environmental Health, 28, 97-106. http://dx.doi.org/10.1515/reveh-2013-0006
Hardell, L., Carlberg, M., Soderqvist, F. and Hansson Mild, K. (2013) Case-Control Study of the Association between Malignant Brain Tumors between 2007 and 2009 and Mobile and Cordless Phone Use. International Journal of Oncology, 43, 1833-1845.
Hardell, L., Carlberg, M., Soderqvist, F. and Hansson Mild, K. (2013) Pooled Analysis on Acoustic Neuroma Diagnosed 1997-2003 and 2007-2009 and Use of Mobile and Cordless Phones. International Journal of Oncology, 43, 1036-1044.
Carlberg, M., Hansson Mild, K. and Hardell, L. (2013) Use of Mobile Phones and Cordless Phones Is Associated with Increased Risk for Glioma and Acoustic Neuroma. Pathophysiology, 20, 85-110. http://dx.doi.org/10.1016/j.pathophys.2012.11.001
Carlberg, M., Soderqvist, F., Hansson Mild, K. and Hardell, L. (2013) Meningioma Patients Diagnosed 2007-2009 and the Association with the Use of Mobile and Cordless Phones: A Case-Control Study. Environmental Health, 12, 60. http://www.ehjournal.net/content/12/1/60 http://dx.doi.org/10.1186/1476-069X-12-60
Hardell, L., Carlberg, M. and Hansson Mild, K. (2011) Pooled Analysis of Case-Control Studies on Malignant Brain Tumors and the Use of Mobile and Cordless Phones and Deceased Subjects. International Journal of Oncology, 38, 1465-1474. http://dx.doi.org/10.3892/ijo.2011.947
Hardell, L., Carlberg, M. and Hansson Mild, K. (2006) Pooled Analysis of Two Case-Control Studies on Use of Cellular and Cordless Telephones and the Risk for Malignant Brain Tumors Diagnosed in 1997-2003. International Archives of Occupational and Environmental Health, 79, 630-639.
Hardell, L., Carlberg, M. and Hansson Mild, K. (2005) Use of Cellular Telephones and Brain Tumor Risk in Urban and Rural Areas. Occupational and Environmental Medicine, 62, 390-394. http://dx.doi.org/10.1136/oem.2004.017434
Interphone Study Group (2011) Acoustic Neuroma Risk in Relation to Mobile Telephone Use: Results of the INTERPHONE International Case-Control Study. Cancer Epidemiology, 35, 453-464.
Interphone Study Group (2010) Brain Tumor Risk in Relation to Mobile Telephone Use: Results of the INTERPHONE International Case-Control Study. International Journal of Epidemiology, 39, 675-694. http://dx.doi.org/10.1093/ije/dyq079
Moon, I.S., Kim, B.G., Kim, J., Lee, J.D. and Lee, W.S. (2014) Association between Vestibular Schwannomas and Mobile Phone Use. Tumor Biology, 35, 581-587. http://dx.doi.org/10.1007/s13277-013-1081-8
Petterson, D., Mathiesen, T., Prochazka, M., Bergenheim, T., Florentzson, R., Harder, H., Nyberg, G., Siesjo, P. and Feychting, M. (2014) Long-Term Mobile Phone Use and Acoustic Neuroma Risk. Epidemiology, 25, 233-241. http://dx.doi.org/10.1097/EDE.0000000000000058
Sato, Y., Akiba, S., Kubo, O. and Yamaguchi, N. (2011) A Case-Case Study of Mobile Phone Use and Acoustic Neuroma Risk in Japan. Bioelectromagnetics, 32, 85-93. http://dx.doi.org/10.1002/bem.20616
Swerdlow, A.J., Feychting, M., Green, A.C., Kheifets, L. and Savitz, D. (2011) Mobile Phones, Brain Tumors and the Interphone Study: Where Are We Now? Environmental Health Perspectives, 119, 1534-1538. http://dx.doi.org/10.1289/ehp.1103693
Lahkola, A., Salminen, T., Raitanen, J., Heinavaara, S., Schoemaker, M.J., Christensen, C.H., Feychting, M., Hohansen, C., Klaeboe, L., Lonn, S., Swerdlow, A.J., Tynes, T. and Auvinen, A. (2008) Meningioma and Mobile Phone Use—A Collaborative Case-Control Study in Five North European Countries. International Journal of Epidemiology, 37, 1304-1313. http://dx.doi.org/10.1093/ije/dyn155
Takebayashi, T., Varsier, N., Kikuchi, Y., Wake, K., Taki, M., Watanabe, S., Akiba, S. and Yamaguchi, N. (2008) Mobile Phone Use, Exposure to Radiofrequency Electromagnetic Field, and Brain Tumor: A Case-Control Study. British Journal of Cancer, 98, 652-659. http://dx.doi.org/10.1038/sj.bjc.6604214
Hours, M., Bernardt, M., Montestrucq, L., Arslan, M., Bergerer, A., Deltour, I. and Cardis, E. (2007) Cell Phones and Risk of Brain and Acoustic Nerve Tumors: The French INTERPHONE Case-Control Study. Epidemiol Public Health, 55, 321-332.
Sadetzki, S., Chetrit, A., Jarus-Hakak, A., Cardis, E., Deutch, Y., Duvdevani, S., Zultan, A., Novikov, I., Freedman, L. and Wolf, M. (2007) Cellular Phone Use and Risk of Benign and Malignant Parotid Gland Tumors—A Nationwide Case-Control Study. American Journal of Epidemiology, 167, 457-467.
Schlehofer, B., Schlaefer, K., Blettner, M., Berg, G., Bohler, E., Hetinger, I., Kunna-Grass, K., Wahrendorf, J. and Schuz, J. (2007) Environmental Risk Factors for Sporadic Acoustic Neuroma (Interphone Study Group Germany). European Journal of Cancer, 43, 1741-1747. http://dx.doi.org/10.1016/j.ejca.2007.05.008
Hepworth, S.J., Schoemaker, M.J., Muir, K.R., Swerdlow, A.J., van Tongeren, M.J. and McKinney, P.A. (2006) Mobile Phone Use and Risk of Glioma in Adults: Case-Control Study. British Medical Journal, 332, 883. http://dx.doi.org/10.1136/bmj.38720.687975.55
Klaeboe, L., Blaasaas, K.G. and Tynes, T. (2006) Use of Mobile Phones in Norway and Risk of Intracranial Tumors. European Journal of Cancer Prevention, 16, 158-164.
Lahkola, A., Auvinen, A., Raitanen, J., Schoemaker, M.J., Christensen, H.C., Feychting, M., Johansen, C., Klaeboe, L., Lonn, S., Swerdlow, A.J., Tynes, T. and Salminen, T. (2006) Mobile Phones Use and Risk of Glioma in 5 North European Countries. International Journal of Cancer, 120, 1769-1775.
Lonn, S., Ahlbom, A., Christensen, H.C., Johansen, C., Schuz, J., Edstrom, S., Henriksson, G., Lundgren, J., Wennerberg, J. and Feychting, M. (2006) Mobile Phone Use and Risk of Parotid Gland Tumor. American Journal of Epidemiology, 164, 637-643. http://dx.doi.org/10.1093/aje/kwj242
Schuz, J., Bohler, E., Berg, G., Schlehofer, B., Hettinger, I., Schlaefer, K., Wahrendorf, J., Kunna-Grass, K. and Blettner, M. (2006) Cellular Phone, Cordless Phones and the Risk of Glioma and Meningioma (Interphone Study Group Germany). American Journal of Epidemiology, 163, 512-520.
Lonn, S., Ahlbom, A., Hall, P. and Feychting, M. (2005) Long-Term Mobile Phone Use and Brain Tumor Risk. American Journal of Epidemiology, 161, 526-535. http://dx.doi.org/10.1093/aje/kwi091
Schoemaker, M.J., Swerdlow, A.J., Ahlbom, A., Auvinen, A., Blaassas, K.G., Cardis, E., Christensen, H.C., Feychting, M., Hepworth, S.J., Johansen, C., Klaeboe, L., Lonn, S., McKinney, P.A., Muir, K., Raitanen, J., Salminen, T., Thomsen, J. and Tynes, T. (2005) Mobile Phone Use and Risk of Acoustic Neuroma: Results of the Interphone Case-Control Study in Five North European Countries. British Journal of Cancer, 93, 842-848. http://dx.doi.org/10.1038/sj.bjc.6602764
Lonn, S., Hall, P. and Feychting, M. (2004) Mobile Phone Use and the Risk of Acoustic Neuroma. Epidemiology, 15, 653-659. http://dx.doi.org/10.1097/01.ede.0000142519.00772.bf
Christensen, H.C., Schuz, J., Kosteljanetz, M., Paulsen, H.S., Thomsen, J. and Johansen, C. (2004) Cellular Telephone Use and Risk of Acoustic Neuroma. American Journal of Epidemiology, 159, 277-283. http://dx.doi.org/10.1093/aje/kwh032
Auvinen, A., Hietanen, M., Luukkonen, R. and Koskela, R.S. (2002) Brain Tumors and Salivary Gland Cancers among Cellular Telephone Users. Epidemiology, 13, 356-359. http://dx.doi.org/10.1097/00001648-200205000-00018
Inskip, P.D., Tarone, R., Hatch, E., Wilcosky, T.C., Sjapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Loeffler, J.S. and Kinet, M.S. (2001) Cellular Telephone Use and Brain Tumors. New England Journal of Medicine, 344, 79-86. http://dx.doi.org/10.1056/NEJM200101113440201
Ahlbom, A., Feychting, M., Green, A., Kheifets, L., Savitz, D.A. and Swerdlow, A.J. (2009) Epidemiologic Evidence on Mobile Phone and Tumor Risk: A Review. Epidemiology, 20, 639-652. http://dx.doi.org/10.1097/EDE.0b013e3181b0927d
Kundi, M. (2009) The Controversy about a Possible Relationship between Mobile Phone Use and Cancer. Environmental Health Perspectives, 117, 316-324. http://dx.doi.org/10.1289/ehp.11902