Bisphenol A (BPA) Contamination in Whole Milk Marketed in Different Packages — Oak Academic Publishing
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Bisphenol A (BPA) Contamination in Whole Milk Marketed in Different Packages
Graduate Program in Sanitary Surveillance (PPGVS), National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
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Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
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Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
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Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
1 Graduate Program in Sanitary Surveillance (PPGVS), National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
2 Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
3 Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
4 Chemistry Department, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
Bisphenol A (BPA), an important endocrine disruptor, is used in the manufacturing of various materials, including food packaging. Ingestion of contaminated foodstuffs is, in fact, the most relevant form of exposure to this substance. However, scarce data on the presence of this contaminant in milk, or whether different types of food packaging influence food contamination are available in Brazil. This study, therefore, aimed to evaluate the BPA contamination of whole milk (fluid and powder) samples packaged in different types of packaging (Tetra Pak?; PET: Poly (ethylene terephthalate; Metallic can (epoxy resin); Polyethylene (PE) and poly (vinylidene chloride) (PVDC); Laminated Film - Metallized Polyester-Polyethylene and glass) and marketed metropolitan region of Rio de Janeiro, Brazil. An analytical method for the BPA determination in milk was optimized for both fluid (pasteurized and ultra-high temperature) and powdered milk samples. A modified QuEChERS method was applied, and BPA determinations were conducted by ultra-performance liquid chromatography coupled with sequential mass spectrometry (HPLC-MS/MS). The validated method was then applied to 51 milk samples, where BPA was detected in five samples (9.8%) and quantified in two (3.8%).
KeywordsBisphenol A. PackagingMigrationMilkEndocrine Disruptors
Environmental Protection Agency EPA (1997) Special Report on Environmental Endocrine Disruption: An Effects Assessment and Analysis.
Bila, D.M. and Dezotti, M. (2007) Desreguladores endócrinos no meio ambiente: Efeitos e consequências. Química Nova, 30, 651-666. https://doi.org/10.1590/S0100-40422007000300027
Ghiselli, G. and Jardim, W.F. (2007) Interferentes endcrinos no ambiente. Química Nova, 30, 695-706. https://doi.org/10.1590/S0100-40422007000300032
Peña-Corona, S.I., Vargas-Estrada, D., Juárez-Rodríguez, I., Retana-Márquez, S. and Mendoza-Rodríguez, C.A. (2023) Bisphenols as Promoters of the Dysregulation of Cellular Junction Proteins of the Blood-Testis Barrier in Experimental Animals: A Systematic Review of the Literature. Journal of Biochemical and Molecular Toxicology, e23416. https://doi.org/10.1002/jbt.23416
Pontelli, R.C.N., Nunes, A.A. and Oliveira, S.V.B. (2016) Impacto na saúde humana de disruptores endócrinos presentes em corpos hídricos: Existe associação com a obesidade? Ciência e Saúde Coletiva, 21, 753-766. https://doi.org/10.1590/1413-81232015213.25212015
Wang, T., Li, M., Chen, B., Xu, M., Xu, Y., Huang, Y., Lu, J., Chen, Y., Wang, W., Li, X., Liu, Y., Bi, Y., Lai, S. and Ning, G. (2012) Urinary Bisphenol A (BPA) Concentration Association with Obesity and Insulin Resistance. The Journal of Clinical Endocrinology & Metabolism, 97, E223-E227. https://doi.org/10.1210/jc.2011-1989
Ige, A., Adebayo, O., Adele, B., Odetola, A., Emediong, I. and Adewoye, E. (2022) Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats. Journal of Biosciences and Medicines, 10, 60-78. https://doi.org/10.4236/jbm.2022.109006
National Library of Medicine (2017) Compound Summary Bisphenol A. https://pubchem.ncbi.nlm.nih.gov/compound/6623
Almeida, S., Raposo, A., Almeida-González, M. and Carrascosa, C. (2018) Bisphenol A: Food Exposure and Impact on Human Health. Comprehensive Reviews in Food Science and Food Safety, 17, 1503-1517. https://doi.org/10.1111/1541-4337.12388
Brasil (2012) RDC n° 56, de 16 de novembro de 2012. Ministério da Saúde (anvisa.gov.br).
Emergen Research (2022) Bisphenol A Market, by Application (Epoxy Resins, Polycarbonate Resins, Unsaturated Polyester Resins, Flame Retardants, Polysulfone Resins, Polyacrylate), by Industry Vertical (Automotive, Electronics, Medical, Paints & Coatings, Packaging), by Distribution Channel (Direct, Indirect), and by Region Forecast to 2028. Bisphenol A Industry Forecast|BPA Market Report 2021-2028. https://emergenresearch.com
García Ibarra, V., Quirós, R.R.A., Losada, P.P. and Sendón, R. (2019) Non-Target Analysis of Intentionally and Non-Intentionally Added Substances from Plastic Packaging Materials and Their Migration into Food Simulants. Food Packaging and Shelf Life, 21, Article ID: 100325. https://doi.org/10.1016/j.fpsl.2019.100325
Tumu, K., Vorst, K. and Curtwiler, G. (2023) Endocrine Modulating Chemicals in Food Packaging: A Review of Phthalates and Bisphenols. Comprehensive Reviews in Food Science and Food Safety, 22, 1337-1359. https://doi.org/10.1111/1541-4337.13113
European Commission (2014) Commission Directive 2014/81/EU: Amending Appendix C of Annex II to Directive 2009/48/EC of the European Parliament and of the Council on the Safety of Toys, as Regards Bisphenol A.
European Commission (2018) Commission Regulation (EU) 2018/213: On the Use of Bisphenol A in Varnishes and Coatings Intended to Come into Contact with Food and Amending Regulation (EU) No 10/2011 as Regards the Use of That Substance in Plastic Food Contact Materials.
Guart, A., Bono-Blay, F., Borrell, A. and Lacorte, S. (2011) Migration of Plasticizers Phthalates, Bisphenol A and Alkylphenols from Plastic Containers and Evaluation of Risk. Food Additives & Contaminants, 28, 676-685. https://doi.org/10.1080/19440049.2011.555845
Casajuana, N. and Lacorte, S. (2003) Presence and Release of Phthalic Esters and Other Endocrine Disrupting Compounds in Drinking Water. Chromatographia, 57, 649-655. https://doi.org/10.1007/BF02491744
Casajuana, N. and Lacorte, S. (2004) New Methodology for the Determination of Phthalate Esters, Bisphenol A, Bisphenol A Diglycidyl Ether, and Nonylphenol in Commercial Whole Milk Samples. Journal of Agricultural and Food Chemistry, 52, 3702-3707. https://doi.org/10.1021/jf040027s
Bano, S., Hayat, M., Samreen, T., Asif, M., Habiba, U. and Uzair, B. (2020) Detection of Pathogenic Bacteria Staphylococcus aureus and Salmonella sp. From Raw Milk Samples of Different Cities of Pakistan. Natural Science, 12, 295-306. https://doi.org/10.4236/ns.2020.125026
van Asselt, E.D., van der Fels-Klerx, H.J., Marvin, H.J.P., van Bokhorst-van de Veen, H. and Groot, M.N. (2017) Overview of Food Safety Hazards in the European Dairy Supply Chain. Comprehensive Reviews in Food Science and Food Safety, 16, 59-75. https://doi.org/10.1111/1541-4337.12245
Geens, T., Aerts, D., Berthot, C., Bourguignon, J.P., Goeyens, L., Lecomte, P., Maghuin-Rogister, G., Pironnet, A.M., Pussemier, L., Scippo, M.L., Van Loco, J. and Covaci, A. (2012) A Review of Dietary and Non-Dietary Exposure to Bisphenol A. Food and Chemical Toxicology, 50, 3725-3740. https://doi.org/10.1016/j.fct.2012.07.059
Danaher, M. and Jordan, K. (2013) Identification of Existing and Emerging Chemical Residue Contamination Concerns in Milk. Irish of Journal Agricultural and Food Research, 52, 173-183. http://hdl.handle.net/11019/533
Przybylski, C. and Segard, C. (2009) Method for Routine Screening of Pesticides and Metabolites in Meat Based Baby-Food Using Extraction and Gas Chromatography-Mass Spectrometry. Journal of Separation Science, 32, 1858-1867. https://doi.org/10.1002/jssc.200900016
Sartori, A.V., Mattos, J.S., de Moraes, M.H.P. and Nóbrega, A.M. (2015) Determination of Aflatoxins M1, M2, B1, B2, G1, and G2 and Ochratoxin A in UHT and Powdered Milk by Modified QuEChERS Method and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. Food Analytical Methods, 8, 2321-2330. https://doi.org/10.1007/s12161-015-0128-4
Souza. P.S., Krauss, T.M., Sartori, A.V. and Abrantes, S.M.P. (2023) Simplified QuEChERS Technique Followed by UHPLC-MS/MS Analysis for the Determination Bisphenol A in Whole and Powdered Milk. International Food Research Journal, 30, 524-535. https://doi.org/10.47836/ifrj.30.2.21
Souza, S.V.C. and Junqueira, R.G. (2005) A Procedure to Assess Linearity by Ordinary Least Squares Method. Analytica Chimica Acta, 552, 25-35. https://doi.org/10.1016/j.aca.2005.07.043
Association of Official Analytical Chemists (2016) International, Official Methods of Analysis of AOAC International. Appendix F: Guidelines for Standard Method Performance Requirements.
European Commission Decision. Commission Decision n° 2002/657/CE. https://op.europa.eu/en/publication-detail/-/publication/ed928116-a955-4a84-b10a-cf7a82bad858
Kang, J.H. and Kondo, F. (2003) Determination of Bisphenol A in Milk and Dairy Products by High-Performance Liquid Chromatography with Fluorescence Detection. Journal of Food Protection, 66, 1439-1443. https://doi.org/10.4315/0362-028X-66.8.1439
Sajiki, J., Miyamoto, F., Fukata, H., Mori, C., Yonekubo, J. and Hayakawa, K. (2007) Bisphenol A (BPA) and This Source in Foods in Japanese Markets. Food Additives & Contaminants, 24, 103-112. https://doi.org/10.1080/02652030600936383
Niu, Y., Zhang, J., Duan, H., Wu, Y. and Shao, B. (2015) Bisphenol A and Nonylphenol in Foodstuffs: Chinese Dietary Exposure from the 2007 Total Diet Study and Infant Health Risk from Formulas. Food Chemistry, 167, 320-325. https://doi.org/10.1016/j.foodchem.2014.06.115
Liao, C. and Kannan, K. (2014) A Survey of Bisphenol A and Other Bisphenol Analogues in Foodstuffs from Nine Cities in China. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 31, 319-329. https://doi.org/10.1080/19440049.2013.868611
Shao, B., Han, H., Tu, X. and Huang, L. (2007) Analysis of Alkylphenol and Bisphenol A in Eggs and Milk by Matrix Solid Phase Dispersion Extraction and Liquid Chromatography with Tandem Mass Spectrometry. Journal of Chromatography B, 850, 412-416. https://doi.org/10.1016/j.jchromb.2006.12.033
Bemrah, N., Jean, J., Rivière, G., Sanaa, M., Leconte, S., Bachelot, M., Deceuninck, Y., Bizec, B.L., Dauchy, X. and Roudot, A.C., Camel, V., Grob, K., Feidt, C., Picard-Hagen, N., Badot, P.M., Foures, F. and Leblanc, J.C. (2014) Assessment of Dietary Exposure to Bisphenol A in the French Population with A Special Focus on Risk Characterisation for Pregnant French Women. Food and Chemical Toxicology, 72, 90-97. https://doi.org/10.1016/j.fct.2014.07.005
Liu, X., Ji, Y., Zhang, H. and Liu, M. (2008) Elimination of Matrix Effects in the Determination of Bisphenol A in Milk by Solid-Phase Microextraction-High-Performance Liquid Chromatography. Food Additives & Contaminants, 25, 772-778. https://doi.org/10.1080/02652030701713921
Ackerman, L.K., Noonan, G.O., Heiserman, W.M., Roach, J.A. and Begley, W.L. (2010) Determination of Bisphenol A in U.S. Infant Formulas: Updated Methods and Concentrations. Journal of Agricultural and Food Chemistry, 58, 2307-2313. https://doi.org/10.1021/jf903959u
Maragou, N.C., Lampi, E.N., Thomaidis, N.S. and Koupparis, M.A. (2006) Determination of Bisphenol A in Milk by Solid Phase Extraction and Liquid Chromatography-Mass Spectrometry. Journal of Chromatography A, 1129, 165-173. https://doi.org/10.1016/j.chroma.2006.06.103
Bomfim, M.V.J., Silvestre, F.B., Zamith, H.P. and Abrantes, S.M.P. (2015) Determinação de bisfenol A em fórmulas infantis. Revista Visa em Debate, 3, 85-90. https://doi.org/10.3395/2317-269x.00415