Environmental monitoring of airborne formaldehyde (FA) using sensitive methodologies is fundamental to prevent health risks. The objective of this study was to compare three different FA monitoring methods during the daily activities of an anatomic pathology laboratory. Daily eight-hour measurements deriving from Radiello® passive diffusive samplers (PDS), NEMo XT continuous optical sensor (COS), and multi-gas 1512 photoacoustic monitor (MPM) were simultaneously compared over a period of 14 working days. Given the different daily distributions of the measurements performed by the three devices, all measurements were time-aligned for comparison purposes. The 95% limit of agreement (LOA) method was applied to estimate the degree of concordance of each device with respect to the others. Formaldehyde arithmetic mean measured using PDS was 32.6 ± 10.4 ppb (range: 19.8 - 62.7). The simultaneous measures performed by COS and MPM were respectively 42.4 ± 44.8 ppb (range: 7.0 - 175.0) and 189.0 ± 163.7 ppb (range: 40.0 - 2895.4). The MPM geometric mean (171.3 ppb) was approximately five times higher than those derived from COS (32.3 ppb) and PDS (31.4 ppb). The results of the LOA method applied to log-transformed FA data showed the same systematic discrepancies between MPM and the other two devices. A good agreement between PDS and COS could lead to a tailored approach according to the individual specificity of these techniques. This tool may be useful for accurately assessing the risk of FA exposure among healthcare workers. However, the limited specificity of the MPM does not support its use as a monitoring method for FA in the workplace.
KeywordsOccupational ExposureOccupational HealthFormaldehyde Monitoring DevicesIndoor Air Quality
World Health Organization (2001) Chapter 5.8. Formaldehyde. In: Air Quality Guidelines , WHO, 1-25.
Duong, A., Steinmaus, C., McHale, C.M., Vaughan, C.P. and Zhang, L. (2011) Reproductive and Developmental Toxicity of Formaldehyde: A Systematic Review. Mutation Research / Reviews in Mutation Research , 728, 118-138. https://doi.org/10.1016/j.mrrev.2011.07.003
Kosmider, L., Cox, S., Zaciera, M., Kurek, J., Goniewicz, M.L., McRobbie, H., et al . (2020) Daily Exposure to Formaldehyde and Acetaldehyde and Potential Health Risk Associated with Use of High and Low Nicotine E-Liquid Concentrations. Scientific Reports , 10, Article No. 6546. https://doi.org/10.1038/s41598-020-63292-1
Motta, O., Charlier, B., De Caro, F., Coglianese, A., Rosa, F., Moccia, G., et al . (2021) Environmental and Biological Monitoring of Formaldehyde Inside a Hospital Setting: A Combined Approach to Manage Chemical Risk in Workplaces. Journal of Public Health Research , 10, Article No. 2012. https://doi.org/10.4081/jphr.2021.2012
Shetty, J.K., Babu, H.F. and Hosapatna Laxminarayana, K.P. (2020) Histomorphological Assessment of Formalin versus Nonformalin Fixatives in Diagnostic Surgical Pathology. Journal of Laboratory Physicians , 12, 271-275. https://doi.org/10.1055/s-0040-1722546
Zain, S.M.S.M., Azmi, W.N.F.W., Veloo, Y. and Shaharudin, R. (2019) Formaldehyde Exposure, Health Symptoms and Risk Assessment among Hospital Workers in Malaysia. Journal of Environmental Protection , 10, 861-879. https://doi.org/10.4236/jep.2019.106051
Doty, R.L., Cometto-Muñiz, J.E., Jalowayski, A.A., Dalton, P., Kendal-Reed, M. and Hodgson, M. (2004) Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans. Critical Reviews in Toxicology , 34, 85-142. https://doi.org/10.1080/10408440490269586
Pala, M., Ugolini, D., Ceppi, M., Rizzo, F., Maiorana, L., Bolognesi, C., et al . (2008) Occupational Exposure to Formaldehyde and Biological Monitoring of Research Institute Workers. Cancer Detection and Prevention , 32, 121-126. https://doi.org/10.1016/j.cdp.2008.05.003
Coggon, D., Harris, E.C., Poole, J. and Palmer, K.T. (2003) Extended Follow-Up of a Cohort of British Chemical Workers Exposed to Formaldehyde. Journal of the N a tional Cancer Institute , 95, 1608-1615. https://doi.org/10.1093/jnci/djg046
Allegra, A., Spatari, G., Mattioli, S., Curti, S., Innao, V., Ettari, R., et al . (2019) Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature. Medicina , 55, Article No. 638. https://doi.org/10.3390/medicina55100638
Beane Freeman, L.E., Blair, A., Lubin, J.H., Stewart, P.A., Hayes, R.B., Hoover, R.N., et al . (2009) Mortality from Lymphohematopoietic Malignancies among Workers in Formaldehyde Industries: The National Cancer Institute Cohort. JNCI : Journal of the National Cancer Institute , 101, 751-761. https://doi.org/10.1093/jnci/djp096
Environmental Protection Agency, Office of Air and Radiation (1989) Report to Congress on Indoor Air Quality, Volume II: Assessment and Control of Indoor Air Pollution.
International Agency for Research on Cancer (2006) IARC Working Group on the Evaluation of Carcinogenic Risk to Humans Formaldehyde, 2-Butoxyethanol and 0-Tert-Butoxy-Propan-2-Ol.
World Health Organization (2010) Formaldehyde. In: Selected Pollutants , WHO Guidelines for Indoor Air Quality , WHO, 103-156.
American Conference of Governmental Industrial Hygienists (2017) Documentation of the TLVs and BEIs with Other Worldwide Occupational Exposure Values. ACGIH.
European Parliament & Council of the European Union (2019) Directive (EU) 2019/983 of the European Parliament and of the Council of 5 June 2019 Amending Directive 2004/37/ EC on the Protection of Workers from the Risks Related to Exposure to Carcinogens or Mutagens at Work.
Lang, I., Bruckner, T. and Triebig, G. (2008) Formaldehyde and Chemosensory Irritation in Humans: A Controlled Human Exposure Study. Regulatory Toxicology and Pharmacology , 50, 23-36. https://doi.org/10.1016/j.yrtph.2007.08.012
ISO 16000-3:2001 (2001) Indoor Air-Part 3: Determination of Formaldehyde and Other Carbonyl Compounds-Active Sampling Method. Standard, ISO 16000-3:2001 (2001-09-01).
ISO 16000-4:2004 (2004) Indoor Air-Part 4: Determination of Formaldehyde-Diffusive Sampling Method. Standard, ISO 16000-4:2004 (2004-05-15).
Szulejko, J.E. and Kim, K. (2015) Derivatization Techniques for Determination of Carbonyls in Air. TrAC Trends in Analytical Chemistry , 64, 29-41. https://doi.org/10.1016/j.trac.2014.08.010
Chiappini, L., Dagnelie, R., Sassine, M., Fuvel, F., Fable, S., Tran-Thi, T., et al . (2010) Multi-Tool Formaldehyde Measurement in Simulated and Real Atmospheres for Indoor Air Survey and Concentration Change Monitoring. Air Quality , Atmosphere & Health , 4, 211-220. https://doi.org/10.1007/s11869-010-0102-7
Lee, E.G., Magrm, R., Kusti, M., Kashon, M.L., Guffey, S., Costas, M.M., et al . (2016) Comparison between Active (Pumped) and Passive (Diffusive) Sampling Methods for Formaldehyde in Pathology and Histology Laboratories. Journal of Occupatio n al and Environmental Hygiene , 14, 31-39. https://doi.org/10.1080/15459624.2016.1211284
Mucci, N., Dugheri, S., Rapisarda, V., Campagna, M, Garzaro, G., Farioli, A., Cappelli, G. and Arcangeli, G. (2019) Occupational Exposure to Airborne Formaldehyde in Hospital: Setting an Automatic Sampling System, Comparing Different Monitoring Methods and Applying Them to Assess Exposure. Medicina del Lavoro , 110, 446-458.
Villanueva, F., Colmenar, I., Mabilia, R., Scipioni, C. and Cabañas, B. (2013) Field Evaluation of the Analyst® Passive Sampler for the Determination of Formaldehyde and Acetaldehyde in Indoor and Outdoor Ambient Air. Analytical Methods , 5, 516-524. https://doi.org/10.1039/c2ay25978h
Macey, G.P., Breech, R., Chernaik, M., Cox, C., Larson, D., Thomas, D., et al . (2014) Air Concentrations of Volatile Compounds near Oil and Gas Production: A Community-Based Exploratory Study. Environmental Health , 13, Article No. 82. https://doi.org/10.1186/1476-069x-13-82
Delgado Saborit, J.M. and Esteve Cano, V.J. (2007) Field Comparison of Passive Samplers versus Uv-Photometric Analyser to Measure Surface Ozone in a Mediterranean Area. Journal of Environmental Monitoring , 9, 610-615. https://doi.org/10.1039/b618075b
Fustinoni, S., Campo, L., Spinazzè, A., Cribiù, F.M., Chiappa, L., Sapino, A., et al . (2021) Exposure and Management of the Health Risk for the Use of Formaldehyde and Xylene in a Large Pathology Laboratory. Annals of Work Exposures and Health , 65, 805-818. https://doi.org/10.1093/annweh/wxaa141
Birmili, W., Daniels, A., Bethke, R., Schechner, N., Brasse, G., Conrad, A., et al . (2021) Formaldehyde, Aliphatic Aldehydes (C 2 -C 11 ), Furfural, and Benzaldehyde in the Residential Indoor Air of Children and Adolescents during the German Environmental Survey 2014-2017 (Geres V). Indoor Air , 32, e12927. https://doi.org/10.1111/ina.12927
Dugheri, S., Massi, D., Mucci, N., Berti, N., Cappelli, G. and Arcangeli, G. (2021) Formalin Safety in Anatomic Pathology Workflow and Integrated Air Monitoring Systems for the Formaldehyde Occupational Exposure Assessment. International Journal of Occupational Medicine and Environmental Health , 34, 319-338. https://doi.org/10.13075/ijomeh.1896.01649
UNI EN ISO 7730-2006, Norma tecnica (2006) Ergonomia degli ambienti termici—Determinazione analitica e interpretazione del benessere termico mediante il calcolo degli indici PMV e PPD e dei criteri di benessere termico locale.
Dlgs n. 81/08 (2008) Testo Unico sulla sicurezza nei luoghi di lavoro. Decree Law 9 April 2008 No. 81. Implementation of Article 1 of the Law 3 August 2007 No. 123, Concerning the Protection of Health and Safety in the Workplace.
EN 13528-1:2002 (2002) UNI—Ente Italiano di Normazione. Ambient Air Quality—Diffusive Samplers for the Determination of Concentrations of Gases and Vapours—Requirements and Test Methods—Part 1: General Requirements.
EN 13528-2:2002 (2002) UNI—Ente Italiano di Normazione. Ambient Air Quality—Diffusive Samplers for the Determination of Concentrations of Gases and Vapours-Requirements and Test Methods. Part 2: Specific Requirements and Test Methods.
UNI EN 838:2010 (2010) Atmosphere in the Workplace—Diffusive Samplers for the Determination of Gases and Vapors—Requirements and Test Methods.
Radiello® User Manual 2019 (2019) https : //radiello.com
Bland, J.M. and Altman, D.G. (1999) Measuring Agreement in Method Comparison Studies. Statistical Methods in Medical Research , 8, 135-160. https://doi.org/10.1177/096228029900800204
Herzog-Niescery, J., Steffens, T., Bellgardt, M., Breuer-Kaiser, A., Gude, P., Vogelsang, H., et al . (2019) Photoacoustic Gas Monitoring for Anesthetic Gas Pollution Measurements and Its Cross-Sensitivity to Alcoholic Disinfectants. BMC Anesth e siology , 19, Article No. 148. https://doi.org/10.1186/s12871-019-0822-7
Liu, D., Rong, L., Kamp, J., Kong, X., Adamsen, A.P.S., Chowdhury, A., et al . (2020) Photoacoustic Measurement with Infrared Band-Pass Filters Significantly Overestimates NH 3 Emissions from Cattle Houses Due to Volatile Organic Compound (VOC) Interferences. Atmospheric Measurement Techniques , 13, 259-272. https://doi.org/10.5194/amt-13-259-2020
Wu, P., Li, Y., Lee, C., Chiang, C. and Su, H.J. (2003) Risk Assessment of Formaldehyde in Typical Office Buildings in Taiwan Region. Indoor Air , 13, 359-363. https://doi.org/10.1111/j.1600-0668.2003.00205.x
Ogawa, M., Kabe, I., Terauchi, Y. and Tanaka, S. (2019) A Strategy for the Reduction of Formaldehyde Concentration in a Hospital Pathology Laboratory. Journal of Occupational Health , 61, 135-142. https://doi.org/10.1002/1348-9585.12018
d’Ettorre, G., Caroli, A. and Mazzotta, M. (2021) Minimizing Formaldehyde Exposure in a Hospital Pathology Laboratory. Work , 69, 209-213. https://doi.org/10.3233/wor-213470