Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results) — Oak Academic Publishing
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Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)
The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Ural State Medical University, Ekaterinburg, Russia
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The Institute of Natural Sciences, The Ural Federal University, Yekaterinburg, Russia
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The Ural State Medical University, Ekaterinburg, Russia
,
The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
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The Institute of Natural Sciences, The Ural Federal University, Yekaterinburg, Russia
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The Ural State Medical University, Ekaterinburg, Russia
1 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
2 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
3 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
4 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
5 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
6 The Ural State Medical University, Ekaterinburg, Russia
7 The Institute of Natural Sciences, The Ural Federal University, Yekaterinburg, Russia
8 The Ural State Medical University, Ekaterinburg, Russia
9 The Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
10 The Institute of Natural Sciences, The Ural Federal University, Yekaterinburg, Russia
11 The Ural State Medical University, Ekaterinburg, Russia
Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism’s resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs’ toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs’ oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research.
KeywordsNanoparticlesToxic metalsBioptotectors
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Katsnelson, B.A., Privalova, L.I., Kuzmin, S.V., Gurvich, V.B., Sutunkova, M.P., Kireyeva, E.P. and Minigalieva I.A. (2012) An Approach to Tentative Reference Levels Setting for Nanoparticles in the Workroom Air Based on Comparing Their Toxicity with That of Their Micrometric Counterparts: A Case Study of Iron Oxide Fe3O4. ISRN Nanotechnology, 2012, Article: ID 143613. https://doi.org/10.5402/2012/143613
Katsnelson, B.A., Privalova, L.I., Sutunkova, M.P., Khodos, M.Y., Shur, V.Y., Shishkina, E.V., Tulakina, L.G., Pichugova, S.V. and Beikin, J.B. (2012) Uptake of Some Metallic Nanoparticles by, and Their Impact on Pulmonary Macrophages in Vivo as Viewed by Optical, Atomic Force, and Transmission Electron Microscopy. Journal of Nanomedicine & Nanotechnology, 3, 129.
Katsnelson, B.A., Privalova, L.I., Sutunkova, M.P., Tulakina, L.G., Pichugova, S.V., Beykin, J.B. and Khodos, M.J. (2012) Interaction of Iron Oxide Fe3O4 Nanoparticles and Alveolar Macrophages in Vivo. Bulletin of Experimental Biology and Medicine, 152, 627-629. https://doi.org/10.1007/s10517-012-1593-z
Katsnelson, B.A., Privalova, L.I., Gurvich, V.B., Makeyev, O.H., Shur, V.Ya., Beikin, Ya.B., Sutunkova, M.P., Kireyeva, E.P., Minigalieva, I.A., Loginova, N.V., Vasilyeva, M.S., Korotkov, A.V., Shuman, E.A., Vlasova, L.A., Shishkina, E.V., Tyurnina, A.E., Kozin, R.V., Valamina, I.E., Pichugova, S.V. and Tulakina, L.G. (2013) Comparative in Vivo Assessment of Some Adverse Bio-Effects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors. International Journal of Molecular Sciences, 14, 2449-2483. https://doi.org/10.3390/ijms14022449
Katsnelson, B.A., Minigalieva, I.A., Privalova, L.I., Sutunkova, M.P., Gurvich, V.B., Shur, V.Ya., Shishkina, E.V., Varaksin, A.N. and Panov, V.G. (2014) Lower Airways Response in Rats to a Single or Combined Intratracheal Instillation of Manganese and Nickel Nanoparticles and Its Attenuation with a Bio-Protective Pre-Treatment. Toxicological Review, 129, 8-14.
Katsnelson, B.A., Privalova, L.I., Gurvich, V.B., Kuzmin, S.V., Kireyeva, E.P., Minigalieva, I.A., Sutunkova, M.P., Loginova, N.V., Malykh, O.L., Yarushin, S.V., Soloboyeva, J.I. and Kochneva N.I. (2014) Enhancing Population’s Resistance to Toxic Exposures as an Auxilliary Tool of Decreasing Environmental and Occupational Health Risks (a Self-Overview). Journal of Environmental Protection, 5, 1435-1449. https://doi.org/10.4236/jep.2014.514137
Privalova, L.I., Katsnelson, B.A., Loginova, N.V., Gurvich, V.B., Shur, V.Y., Beikin, Y.B., Sutunkova, M.P., Minigalieva, I.A., Shishkina, E.V., Pichugova, S.V., Tulakina, L.G. and Beljayeva, S.V. (2014) Some Characteristics of Free Cell Population in the Airways of Rats after Intratracheal Instillation of Copper-Containing Nano-Scale Particles. International Journal of Molecular Sciences, 15, 21538-21553. https://doi.org/10.3390/ijms151121538
Privalova, L.I., Katsnelson, B.A., Loginova, N.V., Gurvich, V.B., Shur, V.Y., Valamina, I.E., Makeyev, O.H., Sutunkova, M.P., Minigalieva, I.A., Kireyeva, E.P., Rusakov, V.O., Tyurnina, A.E., Kozin, R.V., Meshtcheryakova, E.Y., Korotkov, A.V., Shuman, E.A., Zvereva, A.E. and Kostykova S.V. (2014) Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors. International Journal of Molecular Sciences, 15, 12379-12406. https://doi.org/10.3390/ijms150712379
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