The deep learning models hold considerable potential for clinical applicatio ns, but there are many challenges to successfully training deep learning models. Large-scale data collection is required, which is frequently only possib le through multi-institutional cooperation. Building large central repositories is one strategy for multi-institution studies . However , this is hampered by issues regarding data sharing, including patient privacy, data de-identification, regulation, intellectual property, and data storage. These difficulties have lessened the impracticality of central data storage. In this survey, we will look at 24 research publications that concentrate on machine learning approaches linked to privacy preservation techniques for multi-institutional data, highlighting the multiple shortcomings of the existing methodologies. Researching different approaches will be made simpler in this case based on a number of factors, such as performance measures, year of publication and journals, achievements of the strategies in numerical assessments, and other factors. A technique analysis that considers the benefits and drawbacks of the strategies is additionally provided. The article also looks at some potential areas for future research as well as the challenges associated with increasing the accuracy of privacy protection techniques. The comparative evaluation of the approaches offers a thorough justification for the research’s purpose.
KeywordsPrivacy Preservation ModelsMulti Institutional DataBio TechnologiesClinical Trial and Pharmaceutical Industry
Sébastien, Z., Crettaz, C., Kim, E., Skarmeta, A., Bernabe, J.B., Trapero, R. and Bianchi, S. (2019) Privacy and Security Threats on the Internet of Things. In: Ziegler, S., Ed., Internet of Things Security and Data Protection, Springer, Berlin, 9-43. https://doi.org/10.1007/978-3-030-04984-3_2
Naser, A.M., Farooque, M.M.J. and Khashab, B.L. (2019) The Effect of Security, Privacy, Familiarity, and Trust on Users’ Attitudes toward the Use of the IoT-Based Healthcare: The Mediation Role of Risk Perception. IEEE Access, 7, 111341-111354. https://doi.org/10.1109/ACCESS.2019.2904006
Tejasvi, A., Chamola, V., Sikdar, B. and Choo, K.-K.R. (2020) Consumer IoT: Security Vulnerability Case Studies and Solutions. IEEE Consumer Electronics Magazine, 9, 17-25. https://doi.org/10.1109/MCE.2019.2953740
Swaroop, P. (2016) Internet of Things: Underlying Technologies, Interoperability, and Threats to Privacy and Security. Berkeley Technology Law Journal, 31, 997-1022.
Suneetha, V., Suresh, S. and Jhananie, V. (2020) A Novel Framework Using Apache Spark for Privacy Preservation of Healthcare Big Data. 2020 2nd International Conference on Innovative Mechanisms for Industry Applications (ICIMIA), Bangalore, 5-7 March 2020, 743-749. https://doi.org/10.1109/ICIMIA48430.2020.9074867
Saleem, Y., Rehmani, M.H., Crespi, N. and Minerva, R. (2021) Parking Recommender System Privacy Preservation through Anonymization and Differential Privacy. Engineering Reports, 3, e12297. https://doi.org/10.1002/eng2.12297
Shruthi, R. and Govindarasu, M. (2020) An Efficient Framework for Privacy-Preserving Computations on Encrypted IoT Data. IEEE Internet of Things Journal, 7, 8700-8708. https://doi.org/10.1109/JIOT.2020.2998109
Dhaval, J. and Panchal, R. (2021) A Novel Anonymity Algorithm for Privacy Preservation. Elementary Education Online, 20, 2402-2402.
Qi, F., He, D., Wang, H., Zhou, L. and Choo, K.-K.R. (2019) Lightweight Collaborative Authentication with Key Protection for Smart Electronic Health Record System. IEEE Sensors Journal, 20, 2181-2196. https://doi.org/10.1109/JSEN.2019.2949717
Shan, J., Cao, J., McCann, J.A., Yang, Y., Liu, Y., Wang, X. and Deng, Y. (2019) Privacy-Preserving and Efficient Multi-Keyword Search over Encrypted Data on Blockchain. 2019 IEEE International Conference on Blockchain, Atlanta, 14-17 July 2019, 405-410.
Xuyun, Z., Liu, C., Nepal, S. and Chen, J. (2013) An Efficient Quasi-Identifier Index Based Approach for Privacy Preservation over Incremental Data Sets on Cloud. Journal of Computer and System Sciences, 79, 542-555. https://doi.org/10.1016/j.jcss.2012.11.008
Dagher, G.G., Mohler, J., Milojkovic, M. and Marella, P.B. (2018) Ancile: Privacy-Preserving Framework for Access Control and Interoperability of Electronic Health Records Using Blockchain Technology. Sustainable Cities and Society, 39, 283-297. https://doi.org/10.1016/j.scs.2018.02.014
Yong, W., Zhang, A., Zhang, P. and Wang, H. (2019) Cloud-Assisted EHR Sharing with Security and Privacy Preservation via Consortium Blockchain. IEEE Access, 7, 136704-136719. https://doi.org/10.1109/ACCESS.2019.2943153
Sheng, C., Wang, J., Du, X., Zhang, X. and Qin, X. (2020) CEPS: A Cross-Blockchain Based Electronic Health Records Privacy-Preserving Scheme. ICC 2020-2020 IEEE International Conference on Communications (ICC), Dublin, 7-11 June 2020, 1-6.
Nuetey, N.R., Yue, L., Agdedanu, P.R. and Adjeisah, M. (2019) Privacy Module for Distributed Electronic Health Records (EHRs) Using the Blockchain. 2019 IEEE 4th International Conference on Big Data Analytics (ICBDA), Suzhou, 15-18 March 2019, 369-374.
Zhang, M.W., Chen, Y. and Susilo, W. (2020) PPO-CPQ: A Privacy-Preserving Optimization of Clinical Pathway Query for e-Healthcare Systems. IEEE Internet of Things Journal, 7, 10660-10672. https://doi.org/10.1109/JIOT.2020.3007518
Suman, M. and Goswami, P. (2021) A Technique for Securing Big Data Using k-Anonymization with a Hybrid Optimization Algorithm. International Journal of Operations Research and Information Systems (IJORIS), 12, 1-21. https://doi.org/10.4018/IJORIS.20211001.oa3
Jyothi, M. and Rao, C.S. (2019) Privacy Preservation of Data Using Crow Search with Adaptive Awareness Probability. Journal of Information Security and Applications, 44, 157-169. https://doi.org/10.1016/j.jisa.2018.12.005
Rafik, H., Yan, Z., Muhammad, K., Bellavista, P. and Titouna, F. (2020) A Privacy-Preserving Cryptosystem for IoT E-Healthcare. Information Sciences, 527, 493-510. https://doi.org/10.1016/j.ins.2019.01.070
Xue, Y., Lu, R., Shao, J., Tang, X. and Yang, H. (2018) An Efficient and Privacy-Preserving Disease Risk Prediction Scheme for e-Healthcare. IEEE Internet of Things Journal, 6, 3284-3297. https://doi.org/10.1109/JIOT.2018.2882224
Chamikara, M.A.P., Bertok, P., Liu, D., Camtepe, S. and Khalil, I. (2020) Efficient Privacy Preservation of Big Data for Accurate Data Mining. Information Sciences, 527, 420-443. https://doi.org/10.1016/j.ins.2019.05.053
Chen, Z., Zhang, F., Zhang, P., Liu, J.K., Huang, J., Zhao, H. and Shen, J. (2018) Verifiable Keyword Search for Secure Big Data-Based Mobile Healthcare Networks with Fine-Grained Authorization Control. Future Generation Computer Systems, 87, 712-724. https://doi.org/10.1016/j.future.2017.10.022
Saira, K., Iqbal, K., Faizullah, S., Fahad, M., Ali, J. and Ahmed, W. (2020) Clustering Based Privacy Preserving of Big Data Using Fuzzification and Anonymization Operation.
Trisha, D., Apthorpe, N. and Feamster, N. (2018) A Developer-Friendly Library for Smart Home Iot Privacy-Preserving Traffic Obfuscation. Proceedings of the 2018 Workshop on IoT Security and Privacy, Budapest, 20 August 2018, 43-48.
Fang, R., Pouyanfar, S., Yang, Y., Chen, S.C. and Iyengar, S.S. (2016). Computational Health Informatics in the Big Data Age: A Survey. ACM Computing Surveys (CSUR), 49, 1-36.
Abdel-Basset, M., Hawash, H. and Abouhawwash, M. (2022) Collaborative Screening of COVID-19-Like Disease from Multi-Institutional Radiographs: A Federated Learning Approach. Mathematics, 10, 4766.
Gupta, S., Kumar, S., Chang, K., Lu, C., Singh, P. and Kalpathy-Cramer, J. (2023) Collaborative Privacy-Preserving Approaches for Distributed Deep Learning Using Multi-Institutional Data. RadioGraphics, 43, e220107. https://doi.org/10.1148/rg.220107
Shiri, I., Vafaei Sadr, A., Akhavan, A., Salimi, Y., Sanaat, A., Amini, M. and Zaidi, H. (2023) Decentralized Collaborative Multi-Institutional PET Attenuation and Scatter Correction Using Federated Deep Learning. European Journal of Nuclear Medicine and Molecular Imaging, 50, 1034-1050. https://doi.org/10.1007/s00259-022-06053-8
Sun, H., Plawinski, J., Subramaniam, S., Jamaludin, A., Kadir, T., Readie, A. and Coroller, T. (2023) A Deep Learning Approach to Private Data Sharing of Medical Images Using Conditional Generative Adversarial Networks (GANs). PLOS ONE, 18, e0280316. https://doi.org/10.1371/journal.pone.0280316