This paper presents a comprehensive review of Agentic AI frameworks in cybersecurity, with particular emphasis on autonomous threat detection and adaptive incident response. As cyber threats continue to evolve in complexity and scale, traditional rule-based security mechanisms are becoming increasingly ineffective in responding to dynamic and sophisticated attacks. Agentic AI introduces a transformative approach by integrating real-time monitoring, continuous learning, autonomous reasoning, and adaptive decision-making into cybersecurity operations. The review examines recent advances in areas such as autonomous threat detection, SOC automation, adaptive response systems, governance, explainability, and adversarial risks. The findings indicate that Agentic AI significantly improves detection accuracy, accelerates incident response, reduces false positives, and enhances overall cyber resilience through technologies including machine learning, deep learning, reinforcement learning, and multi-agent systems. However, despite these promising developments, current research remains fragmented and faces several limitations, including limited real-world validation, insufficient explainability, governance challenges, and vulnerabilities such as adversarial attacks, data poisoning, and model manipulation. The study highlights the need for secure, transparent, and human-centered deployment strategies, as well as standardized evaluation frameworks and stronger human-AI collaboration models. Overall, Agentic AI represents a promising paradigm for building more intelligent, adaptive, and resilient cybersecurity systems capable of addressing the challenges of modern digital environments.
Sheth, A., Achanta, A., Matam, P., Patel, A., Sharma, P., Janapareddy, N.V.P., et al . (2025) AI Driven Self-Healing Cybersecurity Systems with Agentic AI for Adaptive Threat Response and Resilience. 2025 IEEE Cloud Summit , Washington, 26-27 June 2025, 147-153. https://doi.org/10.1109/cloud-summit64795.2025.00030
Lazer, S.J., Aryal, K., Gupta, M. and Bertino, E. (2026) A Survey of Agentic AI and Cyber-Security: Challenges, Opportunities and Use-Case Prototypes. arXiv: 2601.05293.
Adabara, I., Olaniyi Sadiq, B., Nuhu Shuaibu, A., Ibarahim Danjuma, Y. and Venkateswarlu, M. (2025) A Review of Agentic AI in Cybersecurity: Cognitive Autonomy, Ethical Governance, and Quantum-Resilient Defense. F 1000 Research , 14, Article No. 843. https://doi.org/10.12688/f1000research.169337.1
Sheth, A., Patel, A., Upadhyay, C., Ragothaman, H., Patil, B. and Udayakumar, S.K. (2025) Agentic AI for Autonomous Cyber Threat Hunting and Adaptive Defense in Dynamic Security Environments. 2025 IEEE International Conference on Electro Information Technology ( eIT ), Valparaiso, 29-31 May 2025, 316-321. https://doi.org/10.1109/eit64391.2025.11103697
Sugumar, R. (2024) Next-Generation Security Operations Center (SOC) Resilience: Autonomous Detection and Adaptive Incident Response Using Cognitive AI Agents. International Journal of Technology , Management and Humanities , 10, 62-76.
Indranil, K. (2025) Cognitive Trust Architecture for Mitigating Agentic AI Threats: Adaptive Reasoning and Resilient Cyber Defense. https://philpapers.org/rec/KUMCTA
Evani, P.K. (2025) Agentic AI Security: A Control Framework for Autonomous Decision-Making Systems. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5332681
Kshetri, N. (2025) Transforming Cybersecurity with Agentic AI to Combat Emerging Cyber Threats. Telecommunications Policy , 49, Article ID: 102976.
Adeyemi, D.S. (2023) Autonomous Response Systems in Cybersecurity: A Systematic Review of AI-Driven Automation Tools. Communication in Physical Sciences , 9, 878-898. https://journalcps.com/index.php/volumes/article/view/696/709
Kishore Chakrabarty, P. (2025) Adversarial Attacks on Agentic AI Systems: Mechanisms, Impacts, and Defense Strategies. International Journal of Science and Research ( IJSR ), 14, 1367-1369. https://doi.org/10.21275/sr25417074844
Tallam, K. (2025) Transforming Cyber Defense: Harnessing Agentic and Frontier AI for Proactive, Ethical Threat Intelligence. arXiv: 2503.00164.
Mustafa, A. (2025) Agentic Artificial Intelligence as a Proactive Cybercrime Sentinel for Predictive Detection and Strategic Deterrence of Social Engineering Attacks. https://www.researchgate.net/publication/397997466_Agentic_Artificial_Intelligence_as_a_Proactive_Cybercrime_Sentinel_for_Predictive_Detection_and_Strategic_Deterrence_of_Social_Engineering_Attacks
Malatji, M. (2025) A Cybersecurity AI Agent Selection and Decision Support Framework. arXiv: 2510.01751.
Hernández-Rivas, A., Morales-Rocha, V. and Sánchez-Solís, J.P. (2024) Towards Autonomous Cybersecurity: A Comparative Analysis of Agnostic and Hybrid AI Approaches for Advanced Persistent Threat Detection. In: Rivera, G., Pedrycz, W., Moreno-Garcia, J. and Sánchez-Solís, J.P., Eds., Innovative Applications of Artificial Neural Networks to Data Analytics and Signal Processing , Springer, 181-219. https://doi.org/10.1007/978-3-031-69769-2_8
Hattali, A. (2024) Adaptive AI for Cybersecurity: Revolutionizing Threat Detection and Incident Response through Intelligent Algorithms. https://www.researchgate.net/profile/Albert-Hattali/publication/386525333
Molina, S.B., Nespoli, P. and Mármol, F.G. (2023) Tackling Cyberattacks through AI-Based Reactive Systems: A Holistic Review and Future Vision. arXiv: 2312.06229.
Balassone, F., Mayoral-Vilches, V., Rass, S., Pinzger, M., Perrone, G., Romano, S.P. and Schartner, P. (2025) Cybersecurity AI: Evaluating Agentic Cybersecurity in Attack/Defense CTFs. arXiv: 2510.17521.
Kotte, G. (2025) Securing the Future with Autonomous AI Agents for Proactive Threat Detection and Response. SSRN Electronic Journal . https://doi.org/10.2139/ssrn.5283830
Datta, S., Nahin, S.K., Chhabra, A. and Mohapatra, P. (2025) Agentic AI Security: Threats, Defenses, Evaluation, and Open Challenges. arXiv: 2510.23883.
Bandi, A., Kongari, B., Naguru, R., Pasnoor, S. and Vilipala, S.V. (2025) The Rise of Agentic AI: A Review of Definitions, Frameworks, Architectures, Applications, Evaluation Metrics, and Challenges. Future Internet , 17, Article 404. https://doi.org/10.3390/fi17090404
Salehi, S., Keishing, V., Singh, Y., Wei, D., Khosravi, A., Habibi, P., et al . (2026) Systematic Review: Agentic AI in Neuroradiology: Technical Promise with Limited Clinical Evidence. Journal of Imaging Informatics in Medicine . https://doi.org/10.1007/s10278-025-01839-2
Leo, M., Tan, F., Miao, T. and Anand, G. (2026) From Threat to Trust: Assessing Security Risks of Agentic AI Systems. International Journal of Information Security , 25, Article No. 23. https://doi.org/10.1007/s10207-025-01185-y
Li, B., Saini, A.K., Hernandez, J.G. and Moore, J.H. (2026) Agentic AI and the Rise of in Silico Team Science in Biomedical Research. Nature Biotechnology , 44, 711-725. https://doi.org/10.1038/s41587-026-03035-1
Sharma, D., Meshkat, S., Perivolaris, A., Kamaleddin, M.A., Teferra, B.G., Rueda, A., et al . (2026) Reimagining Psychiatric Care with Agentic AI: Promise, Challenges, and a Roadmap Forward. npj Digital Medicine , 9, Article No. 252. https://doi.org/10.1038/s41746-026-02453-4
Floridi, L., Buttaboni, C., Gertler, N., Hine, E., Morley, J., Novelli, C., et al . (2026) Agentic AI Optimisation (AAIO): What It Is, How It Works, Why It Matters, and How to Deal with It. Minds and Machines , 36, Article No. 25. https://doi.org/10.1007/s11023-026-09779-8
Olujimi, P.A., Owolawi, P.A., Pretorius, A. and Van Wyk, E. (2025) Mapping the Research Landscape of Agentic AI in SMMEs through a Bibliometric Analysis of Patterns and Knowledge Gaps. Discover Artificial Intelligence , 6, Article No. 63. https://doi.org/10.1007/s44163-025-00764-1
Hasan, M.M., Li, H., Fallahzadeh, E., Rajbahadur, G.K., Adams, B. and Hassan, A.E. (2026) An Empirical Study of Testing Practices in Open Source AI Agent Frameworks and Agentic Applications. Empirical Software Engineering , 31, Article No. 124. https://doi.org/10.1007/s10664-026-10857-9
Dholakia, A., Wani, S.G., Ellison, D., Hodak, M., Dutta, D., Nagaraja, S., et al . (2026) Benchmarking Considerations for Agentic AI Systems. In: Nambiar, R. and Poess, M., Eds., Performance Evaluation and Benchmarking , Springer, 89-98. https://doi.org/10.1007/978-3-032-18070-4_6
Al-Bashrawi, M.A., Al-Sharafi, M.A., Elgendy, I.A., Helal, M.Y.I., Anbalagan, M.K., Chae, I., et al . (2026) Agentic AI Systems and the Future of Entrepreneurship: A Perspective on Co-Agency, Innovation, and Ecosystem Transformation. International Entrepreneurship and Management Journal , 22, Article No. 27. https://doi.org/10.1007/s11365-026-01164-2
Khamis, A. (2026) Design and Evaluation of an Agentic AI Framework for Personalized Umrah Trip Planning. Arabian Journal for Science and Engineering , 51, 12299-12319. https://doi.org/10.1007/s13369-025-11021-z