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In Vitro Evaluation of the Physicochemical Compatibility of Four Perfusion Mixtures: Case of an Ampoule of Paluject ® in Glucose Serum with/or without Vogalene ®
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal
Galenic and Industrial Pharmacy Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 1 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 2 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 3 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 4 Biophysics Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal
- 5 Galenic and Industrial Pharmacy Laboratory, Healthy UFR of Thies, University of Thies, Thies, Senegal
- 6 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 7 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 8 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
- 9 Physical Pharmaceutic Laboratory, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal
Journal of Modern Physics·Volume 15 (2024)·Pages 2398–2406·Published 17 December 2024·DOI10.4236/jmp.2024.1513098
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Abstract
In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.
KeywordsPhysicochemical Compatibility and StabilityPerfusionPaluject ®Glucose SerumVogalene ®
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