The physical mechanism of heredity or inheritance of genes is a quantum mechanical and/or quantum computational process. A theory of bio-quantum genetics is established in this paper. Principle of Bio-quantum Genetics is suggested. I propose and define the soft-genes of genetics controlling the processes of heredity or inheritance of genes. This research deals with the quantum mechanisms of Mendel plant heredity and family inheritance as examples of bio-quantum genetics, deepening our understanding of heredity or inheritance. I believe that more contributions will be made to promote researches of bio-quantum genetics or quantum biology at large.
KeywordsBio-Quantum GeneticsQuantum MechanicsGenesSoft GenesQuantum Mechanism of Mendel Plant HeredityQuantum Mechanism of Family Inheritance
Mendel, G. (1866) Versuche über Pflanzenhybriden. Verhandlungen des Naturforschenden Vereines in Brünn, 4, 3-47.
Abbott, S. and Fairbanks, D.J. (2016) Experiments on Plant Hybrids by Gregor Mendel. Genetics, 204, 407-422. https://doi.org/10.1534/genetics.116.195198
Sturtevant, A.H. (2001) A History of Genetics. Cold Spring Harbor Laboratory Press and Electronic Scholarly Publishing Project, Cold Spring Harbor, New York.
Mukherjee, S. (2016) The Gene. Simon & Schuster Inc., New York.
Johannsen, W. (1909) Elemente der Exakten Erblich Keitslehre. Fischer, Jena, 516 p.
Watson, J.D. and Crick, F.H.C. (1953) Genetic Implications of the Structure of Deoxyribonucleic Acid. Nature, 171, 964-967. https://doi.org/10.1038/171964b0
Watson, J.D. (1981) The Double Helix: A Personal Account of the Discovery of the Structure of DNA. Weidenfeld & Nicolson, London.
Wilkins, M. (2003) Maurice Wilkins: The Third Man of the Double Helix: An Autobiography. Oxford University Press, Oxford. https://doi.org/10.1093/oso/9780198606659.001.0001
Slattery, M.L., Curtin, K., Schaffer, D., Anderson, K. and Samowitz, W. (2002) Associations between Family History of Colorectal Cancer and Genetic Alterations in Tumors. International Journal of Cancer, 97, 823-827. https://doi.org/10.1002/ijc.10148
Lynch, H.T. (2002) Cancer Family History and Genetic Testing: Are Malpractice Adjudications Waiting to Happenö Editorials, 97, 518-520. https://doi.org/10.1016/S0002-9270(01)04086-2
Helfand, B.T. (2016) A Comparison of Genetic Risk Score with Family History for Estimating Prostate Cancer Risk. Asian Journal of Andrology, 18, 515-519. https://doi.org/10.4103/1008-682X.177122
Fritz, J., Shiffman, D., Melander, O., Tada, H. and Ulmer, H. (2017) Metabolic Mediators of the Effects of Family History and Genetic Risk Score on Coronary Heart Disease—Findings from the Malm? Diet and Cancer Study. Journal of American Heart Association, 6, e005254. https://doi.org/10.1161/JAHA.116.005254
Iliuta, I.-A., Kalatharan, V., Wang, K., Gall, E.C.-L., Conklin, J., Pourafkari, M., Ting, R., Chen, C., Borgo, A.C., He, N., Song, X., Heyer, C.M., Senum, S.R., Hwang, Y.-H., Paterson, A.D., Harris, P.C., Khalili, K. and Pei, Y. (2017) Polycystic Kidney Disease without an Apparent Family History. Journal of the American Society of Nephrology, 28, 2768-2776. https://doi.org/10.1681/ASN.2016090938
Kristiansen, M., Maple-GrØdem, J., Alves, G., Arepalli, S., Hernandez, D.G., Iwaki, H., Nalls, M.A., Singleton, A., Tysnes, O.-B., Toft, M. and PihlstrØm, L. (2019) A Paradoxical Relationship between Family History, Onset Age, and Genetic Risk in Parkinson’s Disease. Movement Disorders: official journal of the Movement Disorder Society, 34, 298-299. https://doi.org/10.1002/mds.27555
Agre, K., Veach, P.M., Bemmels, H., Wiens, K., LeRoy, B.S. and Hordinsky, M. (2020) Familial Implications of Autoimmune Disease: Recurrence Risks of Alopecia Areata and Associated Conditions in First-Degree Relatives. Journal of Genetic Counseling, 29, 35-43. https://doi.org/10.1002/jgc4.1178
Mohebi, R., Chen, Q., Hegele, R.A. and Rosenson, R.S. (2020) Failure of Cosegregation between a Rare STAP1 Missense Variant and Hypercholesterolemia. Journal of Clinical Lipidology, 14, 636-638. https://doi.org/10.1016/j.jacl.2020.07.010
Hu, D., Li, Y., Zhou, Y., Luo, Y., Cheng, L., Tan, C., Zhang, Q., Zhao, Y. and Liu, Y. (2021) Association of Immunoglobulin G4-Related Disease with a Family History of Malignancy: A Retrospective Study of 168 Cases. Rheumatology & Autoimmunity, 1, 73-82. https://doi.org/10.1002/rai2.12016
Sato, Y., Tsukaguchi, H., Higasa, K., Kawata, N., Inui, K., Linh, T.N.T., Quynh, T.T.H., Inoue Yoshihiko, I., Koiwa, F. and Yoshimura, A. (2021) Positive Renal Familial History in IgA Nephropathy Is Associated with Worse Renal Outcomes: A Single-Center Longitudinal Study. BMC Nephrology, 22, Article No. 230. https://doi.org/10.1186/s12882-021-02425-8
Leys, F., Eschlböck, S., Campese, N., Mahlknecht, P., Peball, M., Goe bel, G., Sidoroff, V., Granata, R., Bonifati, V., Zschocke, J., Kiechl, S., Poewe, W., Seppi, K., Wenning, G.K. and Fanciulli, A. (2022) Family History for Neurodegeneration in Multiple System Atrophy: Does It Indicate Susceptibility? Movement Disorders: Official Journal of the Movement Disorders Society, 37, 2310-2312. https://doi.org/10.1002/mds.29202
Figg, B. (2022) My Family Health Portrait. Journal of Consumer Health on the Internet, 26, 92-101. https://doi.org/10.1080/15398285.2022.2030144
May, T., Smith, C.L., Kelley, W., East, K., Orlando, L., Cochran, M., Colletto, S., Moss, I., Nakano-Okuno, M., Korf, B. and Limdi, N. (2023) Does Genetic Testing Offer Utility as a Supplement to Traditional Family Health History Intake for Inherited Disease Risk? Family Practice, 40, 760-767. https://doi.org/10.1093/fampra/cmad017
Nowak, J. (2020) The Concept of Legal Atavism—The Example of Art. 880 Code of Civil Procedure. Opolskie Studia Administracyjno-Prawne, 17, 95-105. https://doi.org/10.25167/osap.1893
Ji, X. and Cui, Q. (2020) Ancient Genes Can Be Served as Pan-Cancer Diagnostic and Prognostic Biomarkers. Journal of Cellular and Molecular Medicine, 24, 6908-6915. https://doi.org/10.1111/jcmm.15347
Boyle, E.K., Mahon, V. and Diogo, R. (2020) Muscles Lost in Our Adult Primate Ancestors Still Imprint in Us: On Muscle Evolution, Development, Variations, and Pathologies. Current Molecular Biology Reports, 6, 32-50. https://doi.org/10.1007/s40610-020-00128-x
Khozouz, R. (2021) Atavistic Cancer Model: A New Theory of Cancer? BioEssays, 43, e2100206. https://doi.org/10.1002/bies.202100206
Louka, A., Takan, I., Pavlopoulou, A. and Georgakilas, A.G. (2021) Bioinformatic Approaches to the Investigation of the Atavistic Genes Implicated in Cancer. Frontiers in Bioscience (Landmark Edition), 26, 279-311. https://doi.org/10.52586/4944
Pence, C.H. (2022) Whatever Happened to Reversion? Studies in History and Philosophy of Science, 92, 97-108. https://doi.org/10.1016/j.shpsa.2022.01.019
Dhawan, S.S., Yedavalli, V. and Massoud, T.F. (2023) Atavistic and Vestigial Anatomical Structures in the Head, Neck and Spine: An Overview. Anatomical Science International, 98, 370-390. https://doi.org/10.1007/s12565-022-00701-7
Schrödinger, E. (1944) What Is Life? Cambridge University Press, London.
Davies, P. (2004) Quantum Mechanics and the Origin of Life. IAU Symposium, 213, 237-243. https://doi.org/10.1017/S0074180900193349
Dikshit, B. (2018) Origin of Quantum Mechanical Results and Life: A Clue from Quantum Biology. NeuroQuantology, 16, 26-33. https://doi.org/10.14704/nq.2018.16.4.1219
McFadden, J. and Al-Khalili, J. (2018) The Origins of Quantum Biology. Proceedings of the Royal Society A, 474, Article ID: 20180674. https://doi.org/10.1098/rspa.2018.0674
Fioranelli M., Sepehri, A., Roccia, M.G., Rossi, C., Lotti, J., Vojvodic, P., Barygina, V., Vojvodic, A., Vlaskovic-Jovicevic, T., Peric-Hajzler, Z., Matovic, D., Vojvodic, J., Dimitrijevic, S., Sijan, G., Wollina, U., Tirant, M., Thuong, N.V. and Lotti, T. (2019) DNA Waves and Their Applications in Biology. Macedonian Journal of Medical Sciences, 7, 3096-3100. https://doi.org/10.3889/oamjms.2019.767
Tuszynski, J.A. (2020) From Quantum Chemistry to Quantum Biology: A Path toward Consciousness. Journal of Integrative Neuroscience, 19, 687-700. https://doi.org/10.31083/j.jin.2020.04.393
Kim Y., Bertagna, F., D’Souza, E.M., Heyes, D.J., Johannissen, L.O., Nery, E.T., Pantelias, A., Jimenez, A.S.-P., Slocombe, L., Spencer, M.G., Al-Khalili, J., Engel, G.S., Hay, S., Hingley-Wilson, S.M., Jeevaratnam, K., Jones, A.R., Kattnig, D.R., Lewis, R., Sacchi, M., Scrutton, N.S., Silva, S.R.P. and McFadden, J. (2021) Quantum Biology: An Update and Perspective. Quantum Reports, 3, 80-126. https://doi.org/10.3390/quantum3010006
Basieva, I., Khrennikov, A. and Ozawa, M. (2021) Quantum-Like Modeling in Biology with Open Quantum Systems and Instruments. BioSystems, 201, Article ID: 104328. https://doi.org/10.1016/j.biosystems.2020.104328
Bisiani, J., Anugu, A. and Pentyala, S. (2023) It’s Time to Go Quantum in Medicine. Journal of Clinical Medicine, 12, Article No. 4506. https://doi.org/10.3390/jcm12134506
Ogryzko, V.V. (1997) A Quantum-Theoretical Approach to the Phenomenon of Directed Mutations in Bacteria (Hypothesis). BioSystems, 43, 83-95. https://doi.org/10.1016/S0303-2647(97)00030-0
McFadden, J. and Al-Khalili, J. (1999) A Quantum Mechanical Model of Adaptive Mutation. BioSystems, 50, 203-211. https://doi.org/10.1016/S0303-2647(99)00004-0
Dirac, P.A.M. (1958) The Principles of Quantum Mechanics. 4th Edition, The Clarendon Press, Oxford.
Steward, E.G. (2008) Quantum Mechanics. Imperial College Press, London.
Grover, L.K. (1996) A Fast Quantum Mechanical Algorithm for Database Search. In: Proceedings 28th ACM Symposium on the Theory of Computation, ACM Press, New York, 212-219. https://doi.org/10.1145/237814.237866
Grover, L.K. (1997) Quantum Mechanics Helps in Searching for a Needle in a Haystack. Physical Review Letters, 79, 325-328. https://doi.org/10.1103/PhysRevLett.79.325
Nielsen, M.A. and Chuang, I.L. (2000) Quantum Computation and Quantum Information. Cambridge University Press, Cambridge, 248-254.