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Barrier, Adsorptive, and Mechanical Properties of Containers Molded from PET/PP Blends for Use in Pharmaceutical Solutions
Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
- 1 Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
- 2 Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
- 3 Pharmaceutical Development Research Laboratories of Senju Pharmaceutical Co., Ltd., Kobe, Japan
- 4 Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
- 5 Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
- 6 Department of Advanced Fibro-Science, Kyoto Institute of Technology, Kyoto, Japan
Materials Sciences and Applications·Volume 04 (2013)·Pages 589–594·Published 30 September 2013·DOI10.4236/msa.2013.410072
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Abstract
In this study, the adsorptive properties of L-menthol, moisture vapor transmission rate, and mechanical properties of poly (ethylene terephthalate) (PET), polypropylene (PP), and their blends were evaluated in containers fabricated by injection molding without a compatibilizing agent. These containers intended to hold pharmaceutical solutions contain ing lipophilic chemicals such as L-menthol. By the addition of a small amount of PP, the moisture barrier properties of PET were effectively improved, but its anti-adsorptive property was reduced. The strength of the PET/PP blends was reduced, but some PET/PP blends were still able to bear the experimental load required for application in eye-drop con tainers. PET/PP = 9/1 and PET/PP = 8/2 were found to be most applicable for us ing in the fabrication of containers for medicinal solutions .
KeywordsPET/PPBlendBarrierAdsorptiveMechanical Properties
- X. L. Xu, N. N. Yu, Z. Z. Bai, Y. B. Xun, D. Jin, Z. J. Li and H. Cui, “Effect of Menthol on Ocular Drug Delivery,” Graefe’s Archive for Clinical and Experimental Ophthalmology, Vol. 249, No. 10, 2011, pp. 1503-1510. http://dx.doi.org/10.1007/s00417-011-1703-z
- M. G. Sajilata, K. Savitha, R. S. Singhal and V. R. Kanetkar, “Scalping of Flavors in Packaged Foods,” Comprehensive Reviews in Food Science and Food Safety, Vol. 6, No. 1, 2007, pp. 17-35. http://dx.doi.org/10.1111/j.1541-4337.2007.00014.x
- C.-S. Deng, H. E. Assender, F. Dinelli, O. V. Kolosov, G. A. D. Briggs, T. Miyamoto and Y. Tsukahara, “Nucleation and Growth of Gas Barrier Aluminium Oxide on Surfaces of Poly(Ethylene Terephthalate) and Polypropylene: Effects of the Polymer Surface Properties,” Journal of Polymer Science Part B: Polymer Physics, Vol. 38, No. 23, 2000, pp. 3151-3162. http://dx.doi.org/10.1002/1099-0488(20001201)38:23 3.0.CO;2-Q
- “Pharmaceutical Development Q8(R2),” International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline Current Step 4 Version, 2009. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q8_R1/Step4/Q8_R2_Guideline.pdf
- T. Kamako, M. Oya and T. Nishihata, “Prediction of Water Loss from Plastic Container for Eye-Drop in Various Storage Conditions,” PDA Journal of GMP and Validation in Japan, Vol. 3, No. 2, 2001, pp. 97-103. http://dx.doi.org/10.11347/pda.3.97
- M. K. Cheung and D. Chan, “Mechanical and Rheological Properties of Poly(Ethylene Terephthalate)/Polypropylene Blends,” Polymer International, Vol. 43, No. 3, 1997, pp. 281-287. http://dx.doi.org/10.1002/(SICI)1097-0126(199707)43:3 3.0.CO;2-Q
- M. Akbari, A. Zadhoush and M. Haghighat, “PET/PP Blending by Using PP-g-MA Synthesized by Solid Phase,” Journal of Applied Polymer Science, Vol. 104, No. 6, 2007, pp. 3986-3993. http://dx.doi.org/10.1002/app.26253
- C. Papadopoulou and N. Kalfoglou, “Comparison of Compatibilizer Effectiveness for PET/PP Blends: Their Mechanical, Thermal and Morphology Characterization,” Polymer, Vol. 41, No. 7, 2000, pp. 2543-2555. http://dx.doi.org/10.1016/S0032-3861(99)00442-5
- M. Pracella and D. Chionna, “Reactive Compatibilization of Blends of PET and PP Modified by GMA Grafting,” Macromolecular Symposia, Vol. 198, No. 1, 2003, pp. 161-172. http://dx.doi.org/10.1002/masy.200350814
- M. Xanthos, M. W. Young and J. A. Biesenberger, “Polypropylene/Polyethylene Terephthalate Blends Compatibilized through Functionalization,” Polymer Engineering & Science, Vol. 30, No. 6, 1990, pp. 355-365. http://dx.doi.org/10.1002/pen.760300607