PVP/Clay/Vanadium Oxide Nanocomposites Development and Characterization for Potential Use as Controlled Drug Release Matrix in Diabetes’ Treatment — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
PVP/Clay/Vanadium Oxide Nanocomposites Development and Characterization for Potential Use as Controlled Drug Release Matrix in Diabetes’ Treatment
Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
,
Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
1 Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
2 Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
Research in drug release field, nowadays, focuses on more efficient systems for better release of the drug and wider timespan of action, granting several benefits to the patient’s organism and to the industry. The present work aims on developing a matrix of polymer nanocomposite based on Polyvinylpyrrolidone (PVP), bentonite clay and two different vanadium oxides, via spray drying technique. The goal is to achieve a long and steady release of metformin hydrochloride in future formulations with this drug. Since either the nanocomposites or metformin hydrochloride is highly hydrophilic, it is most suited for a future formulation of tablets. For now, the nanocomposites obtained were characterized through Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Thermogravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). The SEM and XRD analysis portrayed a very amorphous and homogenized material. TGA and FTIR proved the insertion of the nanoparticles, thus granting to the new material a slightly higher thermal resistance. The NMR analysis, using T1H parameters, is key for determining the formulations would behave better for extending the resistance of the nanocomposite’s matrix with the drug in later dissolution of tablets.
Kumar, A.P., Depan, D., Tomer, N.S. and Singh, R.P. (2009) Nanoscale Particles for Polymer Degradation and Stabilization-Trends and Future Perspectives. Progress in Polymer Science, 34, 479-515. https://doi.org/10.1016/j.progpolymsci.2009.01.002
Velmurugan, R., Jeyaprakash, P. and Balaganesan, G. (2008) Damping Study of Hybrid Nanocomposites by Low Velocity Impact. Proceedings of International Conference on Aerospace Science and Technology, Bangalore, India, 26-28.
Chandrasekaran, S., Faiella, G., Prado, L.A.S.A., Trolle, F., Mülhaupt, R. and Schulte, K. (2013) Thermally Reduced Graphene Oxide Acting as a Trap for Multiwall Carbon Nanotubes in Bi-Filler Epoxy Composites. Composites: Part A, 49, 51-57. https://doi.org/10.1016/j.compositesa.2013.02.008
Maderuelo, C., Zarzuelo, A. and Lanao, J.M. (2011) Critical Factors in the Release of Drugs from Sustained Release Hydrophilic Matrices. Journal of Controlled Release, 154, 2-19. https://doi.org/10.1016/j.jconrel.2011.04.002
Miranda, A., Millán, M. and Caraballo, I. (2006) Study of the Critical Points of HPMC Hydrophilic Matrices for Controlled Drug Delivery. International Journal of Pharmaceutics, 311, 75-81. https://doi.org/10.1016/j.ijpharm.2005.12.012
Huang, X. and Brazel, C.S. (2001) On the Importance and Mechanisms of Burst Release in Matrix-Controlled Drug Delivery Systems. Journal of Controlled Release, 73, 121-136. https://doi.org/10.1016/S0168-3659(01)00248-6
Homayouni, A., Sadeghi, F., Varshosaz, J., Garekani, H.A. and Nokhodchi, A. (2014) Comparing Various Techniques to Produce Micro/Nanoparticles for Enhancing the Dissolution of Celecoxib Containing PVP. European Journal of Pharmaceutics and Biopharmaceutics, 88, 261-274. https://doi.org/10.1016/j.ejpb.2014.05.022
Büler, V. (2005) Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone. Springer, Berlin, Heidelberg, New York.
Koczkur, K.M., Mourdikoudis, S., Polavarapu, L. and Skrabalak, S.E. (2015) Polyvinylpyrrolidone (PVP) in Nanoparticle Synthesis. Dalton Transactions, 44, 17883-17905. https://doi.org/10.1039/C5DT02964C
Sapir, L., Stanley, C.B. and Harries, D. (2016) Properties of Polyvinylpyrrolidone in a Deep Eutectic Solvent. Journal of Physical Chemistry A, 120, 3253-3259. https://doi.org/10.1021/acs.jpca.5b11927
Monteiro, M.S.S.B., Rodrigues, C.L., Miguez, E. and Tavares, M.I.B. (2016) Development of Polycaprolactone/Poly (Vinyl Alcohol)/Clay Microparticles by Spray Drying. Materials Sciences and Applications, 7, 575. https://doi.org/10.4236/msa.2016.710048
Fedorova, E.V., Buryakina, A.V., Zakharov, A.V., Filimonov, D.A., Lagunin, A.A. and Poroikov, V.V. (2014) Design, Synthesis and Pharmacological Evaluation of Novel Vanadium-Containing Complexes as Antidiabetic Agents. PLoS ONE, 9, e100386. https://doi.org/10.1371/journal.pone.0100386
Pessoa, J.C., Etcheverry, S. and Gambino, D. (2015) Vanadium Compounds in Medicine. Coordination Chemistry Reviews, 301-302, 24-48. https://doi.org/10.1016/j.ccr.2014.12.002
Gohel, M.C. and Jogani, P.D. (2005) A Review of Co-Processed Directly Compressible Excipients. Journal of Pharmacy and Pharmaceutical Sciences, 8, 76-93.
Agnihotri, S.A. and Aminabhavi, T.M. (2004) Controlled Release of Clozapine through Chitosan Microparticles Prepared by a Novel Method. Journal of Controlled Release, 96, 245-259. https://doi.org/10.1016/j.jconrel.2004.01.025
Vanhoorne, V., Peeters, E., Van Snick, B., Remon, J.P. and Vervaet, C. (2014) Crystal Coating via Spray Drying to Improve Powder Tabletability. European Journal of Pharmaceutics and Biopharmaceutics, 88, 939-944. https://doi.org/10.1016/j.ejpb.2014.10.018
De Fronzo, R.A., Hissa, M.N., Garber, A.J., Gross, J.L., Duan, R.Y., Ravichandran, S. and Chen, R. (2009) The Efficacy and Safety of Saxagliptin When Added to Metformin Therapy in Patients with Inadequately Controlled Type 2 Diabetes on Metformin Alone. Diabetes Care, 32, 1649-1655. https://doi.org/10.2337/dc08-1984
Aguiar, M.R.M.P. and Novaes, A.C. (2002) Remocao de metais pesados de efluentes industriais por aluminossilicatos. Química Nova, 25, 1145-1154. https://doi.org/10.1590/S0100-40422002000700015
Ahmed, E.M. (2013) Hydrogel: Preparation, Characterization, and Applications. Journal of Advanced Research, in press.
Alexandre, M. and Dubois, P. (2000) Polymer-Layered Silicate Nanocomposites: Preparation, Properties and Uses of a New Class of Materials. Materials Science and Engineering: Reports, 28, 1-63. https://doi.org/10.1016/S0927-796X(00)00012-7
Bergaya, F. and Lagaly, G. (2001) Surface Modification of Clay Minerals. Applied Clay Science, 19, 1-3. https://doi.org/10.1016/S0169-1317(01)00063-1
Castaneda, L., Alonso, J.C., Ortiz, O., Andrade, E., Saniger, J.M. and Banuelos, J.G. (2003) Spray Pyrolysis Deposition and Characterization of Titanium Oxide Thin Films. Materials Chemistry and Physics, 77, 938-944. https://doi.org/10.1016/S0254-0584(02)00193-1
Costa, A.C.F.M., Vilar, M.A., Lira, H.L., Kiminami, R.H.G.A. and Gama, L. (2006) Síntese e caracterizacao de nanopartículas de TiO2. Ceramica, 52, 255-259. https://doi.org/10.1590/S0366-69132006000400007
Das, D. and Pal, S. (2015) Dextrin/poly (HEMA): pH Responsive Porous Hydrogel for Controlled Release of Ciprofloxacin. International Journal of Biological Macromolecules, 72, 171-178. https://doi.org/10.1016/j.ijbiomac.2014.08.007
Deng, H. and Lei, Z. (2013) Preparation and Characterization of Hollow Fe3-O4/SiO2@PEG-PLA Nanoparticles for Drug Delivery. Composites Part B: Engineering, 54, 194-199. https://doi.org/10.1016/j.compositesb.2013.05.010
Dolenc, A., Kristl, J., Baumgartner, S. and Planinsek, O. (2009) Advantages of Celecoxib Nanosuspension Formulation and Transformation into Tablets. International Journal of Pharmaceutics, 376, 204-212. https://doi.org/10.1016/j.ijpharm.2009.04.038
Ferreira, L., Vidal, M.M., Geraldes, C.F.G.C. and Gil, M.H. (2000) Preparation and Characterization of Gels Based on Sucrose Modified with Glycidil Methacrylate. Carbohydrate Polymers, 41, 15-24. https://doi.org/10.1016/S0144-8617(99)00064-8
Ferrero, C., Massuelle, D., Jeannerat, D. and Doelker, E. (2008) Towards Elucidation of the Drug Release Mechanism from Compressed Hydrophilic Matrices Made of Cellulose Ethers. I. Pulse-Field-Gradient Spin-Echo NMR Study of Sodium Salicylate Diffusivity in Swollen Hydrogels with Respect to Polymer Matrix Physical Structure. Journal of Controlled Release, 128, 71-79. https://doi.org/10.1016/j.jconrel.2008.02.006
Jain, S. and Datta, M. (2014) Montmorillonite-PLGA Nano-composites as an Oral Extended Drug Delivery Vehicle for Venlafaxine Hydrochloride. Applied Clay Science, 99, 42-47. https://doi.org/10.1016/j.clay.2014.06.006
Kaufhold, S., Dohrmann, R., Ufer, K. and Meyer, F.M. (2002) Comparison of Methods for the Quantification of Montmorillonite in Bentonites. Applied Clay Science, 22, 145-151. https://doi.org/10.1016/S0169-1317(02)00131-X
Li, X.L. and Jasti, B.R. (2006) Design of Controlled Release Drug Delivery Systems. McGraw-Hill, New York.
Lv, F., Fu, L., Giannelis, E.P. and Qi, G. (2014) Preparation of γ-Fe2O3/SiO2-Capsule Composites Capable of Using Drug Delivery and Magnetic Targeting System from Hydrophobic Iron Acet-ylacetonate and Hydrophilic SiO2-Capsule. Solid State Sciences, 34, 49-55. https://doi.org/10.1016/j.solidstatesciences.2014.05.006
Mano, E.B. and Mendes, L.C. (1999) Introducao a Polímeros. 2nd Edition, Edgard Blücher, Sao Paulo.
Narasimharao, R., Anusha Reddy, M., Swetha Reddy, N., Divyasagar, P. and Keerthana, K. (2011) Design and Evaluation of Metformin Hydrocloride Extended Release Tablets by Direct Compression. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2, 1118-1133.
Oliveira, M.J.A., Estefania, O.S., Lúcia, M.A.B., Regina, M., Amato, V.S., Lugao, A.B. and Parra, D.F. (2014) Influence of Chitosan/Clay in Drug Delivery of Glucantime from PVP Membranes. Radiation Physics and Chemistry, 94, 194-198. https://doi.org/10.1016/j.radphyschem.2013.05.050
Rigo, V.A., Lara, L.S. and Miranda, C.R. (2014) Energetics of Formation and Hydratation of Functionalized Silica Nanoparticles: An Atomistic Computational Study. Applied Surface Science, 292, 742-749. https://doi.org/10.1016/j.apsusc.2013.12.042
Rodrigues, L.A.S., Figueiras, A., Veiga, F., Freitas, R.M., Nunes, L.C.C., Silva Filho, E.C. and Leite, C.M.S. (2013) The Systems Containing Clays and Clay Minerals from Modified Drug Release: A Review. Colloids and Surfaces B: Biointerfaces, 103, 642-651. https://doi.org/10.1016/j.colsurfb.2012.10.068
Silva, E.P., Sitta, D.L.A., Fragal, V.H., Cellet, T.S., Mauricio, M.R., Garcia, F.P., Nakamura, C.V., Guilherme, M.R., Rubira, A.F. and Kunita, M.H. (2014) Covalent TiO2/Pectin Microspheres with Fe3O4 Nanoparticles for Magnetic Field-Modulated Drug Delivery. International Journal of Biological Macromolecules, 67, 43-52. https://doi.org/10.1016/j.ijbiomac.2014.02.035
Simo, C., Cifuentes, A. and Gallardo, A. (2003) Drug Delivery Systems: Polymers and Drugs Monitored by Capillary Electromigration Methods. Journal of Chromatography B, 797, 37-49. https://doi.org/10.1016/S1570-0232(03)00430-6
Son, J.S., Kim, K.H. and Kwon, T.Y. (2012) Drug Delivery from Titanium Surface Using Biodegradable Nanoparticle Carriers. Materials Letters, 89, 129-132. https://doi.org/10.1016/j.matlet.2012.08.084
Thostenson, E.T., Li, C. and Chou, T.-W. (2005) Nanocomposites in Context. Composites Science and Technology, 65, 491-516. https://doi.org/10.1016/j.compscitech.2004.11.003
Tiwari, S.B. and Rajabi-Siahboomi, A.R. (2008) Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems, Drug Delivery Systems. In: Jain, K.K., Ed., Methods in Molecular Biology, Humana Press, Totowa, NJ, 217-243. https://doi.org/10.1007/978-1-59745-210-6_11
Wang, T., Jiang, H., Wan, L., Zhao, Q., Jiang, T., Wang, B. and Wang, S. (2015) Potential Application of Functional Porous TiO2 Nanoparticles in Light-Controlled Drug Release and Targeted Drug Delivery. Acta Biomaterialia, 13, 354-363. https://doi.org/10.1016/j.actbio.2014.11.010