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Establishment of PEEK-Associated Drug Delivery Systems—Limits and Perspectives
Laboratory for Chemistry and Surface Modification, Hochschule Osnabrück University of Applied Sciences, Osnabrück, Germany
Laboratory for Chemistry and Surface Modification, Hochschule Osnabrück University of Applied Sciences, Osnabrück, Germany
- 1 Laboratory for Chemistry and Surface Modification, Hochschule Osnabrück University of Applied Sciences, Osnabrück, Germany
- 2 Laboratory for Chemistry and Surface Modification, Hochschule Osnabrück University of Applied Sciences, Osnabrück, Germany
Journal of Materials Science and Chemical Engineering·Volume 08 (2020)·Pages 32–41·Published 30 September 2020·DOI10.4236/msce.2020.810004
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Abstract
In order to enhance promising properties of polyethertherketone (PEEK) for biomedical application, we evaluate two different strategies for the provision of PEEK with a drug delivery system at the example of the model drug chlorhexidine diacetate. On one hand we discuss the deposition of a biodegradable polymeric drug-release coating, based on well-established poly(L-lactide) (PLLA), on PEEK and on the other hand the modification of PEEK via sulfonation and its subsequent drug loading. Results are compared to pure PLLA-associated drug delivery systems and limits and perspectives are shown.
KeywordsPolyethertherketoneDrug Chlorhexidine
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