Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One — Oak Academic Publishing
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Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One
Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
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Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
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Department of Fundamental Sciences, Mongo Polytechnique University Institute (IUPM), Mongo, Chad
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Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
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Department of Process Engineering, Laboratory of Energy, Materials, Modeling and Method, National Higher Polytechnic School of Douala, University of Douala, Douala, Cameroon
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Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany
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Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany
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Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
1 Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
2 Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
3 Department of Fundamental Sciences, Mongo Polytechnique University Institute (IUPM), Mongo, Chad
4 Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
5 Department of Process Engineering, Laboratory of Energy, Materials, Modeling and Method, National Higher Polytechnic School of Douala, University of Douala, Douala, Cameroon
6 Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany
7 Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany
8 Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
New cobalt(II) complex, [Co(O 2 C 15 H 11 N 2 S) 2 (OH 2 ) 2 ] ∙ 2H 2 O (1 ∙ 2H 2 O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl) 2 ∙ 6H 2 O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1 ∙ 2H 2 O. Compound 1 ∙ 2H 2 O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1 ∙ 2H 2 O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1 ∙ 2H 2 O displayed moderate activity (10 < MIC ≤ 100 μg/mL) on all Salmonellaand and, F1, and 018 yeasts. HL and 1 ∙ 2H 2 O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).
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