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Synthesis of (2S,4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs
Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
- 1 Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
- 2 Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
- 3 Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
- 4 Institute of Macromolecular Compouns of Russian Academy of Sciences, Saint Petesburg, Russia
Journal of Materials Science and Chemical Engineering·Volume 03 (2015)·Pages 7–12·Published 11 June 2015·DOI10.4236/msce.2015.36002
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Abstract
Proceeding from natural amino acid L-asparagine and commercially available aldehydes a stereoselective synthesis was developed of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahy- dropyrimidine-4-carboxylic acids, potential antihypertensive drugs, inhibitors of the angiotensin converting enzyme.
KeywordsSynthesis of (2S4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs
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