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Carbohydrate-Derived Organocatalysts for the Reduction of Imines with Trichlorosilane
School of Chemical and Material Engineering, Jiangnan University, Wuxi, China
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
- 1 School of Chemical and Material Engineering, Jiangnan University, Wuxi, China
- 2 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
- 3 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China
Journal of Materials Science and Chemical Engineering·Volume 03 (2015)·Pages 48–53·Published 11 June 2015·DOI10.4236/msce.2015.36008
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Abstract
The backbone of D-glucosamine hydrochloride was fine-tuned and modified by protecting the hydroxyl groups. In order to reduce imines with trichlorosilane, the carbohydrate-derived organocatalysts were prepared and screened. Methyl-4,6-O-benzylidene-2-amino-2-deoxy-α-D-glucopyr anoside was found as the best catalyst. The reduction was proceeded under CHCl3 as solvent at 40?C, affording 68% - 94% yield.
KeywordsCarbohydrateOrganocatalystReductionImine
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