Hydrophilic Silica/Copolymer Nanoparticles and Protein-Resistance Coatings
- 1 Xi’an Jiaotong University, School of Science, Department of Chemistry, Xi’an, 710049, China
- 2 Department of Chemistry, School of Science, Xi’an Jiaotong University, Xianning West Road, 28, Xi’an, 710049 China
Abstract
Hydrophilic silica/copolymer nanoparticles of SiO 2 -g-P(PEGMA)-b-P(PEG) are prepared by silica surface-initiating atom transfer radical polymerization (SI-ATRP) of poly (ethylene glycol) methyl ether methacrylate (PEGMA) and poly(ethylene glycol) methacrylate (PEG), by using Three molar ratios of SiO 2 -Br/PEGMA/PEG as 1/42.46/19.44, 1/42.46/38.88 and 1/42.46/77.76. Their temperature sensitive behaviour, pH response and surface properties as protein-resistance coatings are characterized. 220 nm core-shell nanoparticles as P(PEGMA)-b-P(PEG) shell grafted on SiO2 core are formed in water solution, which gained LCST at 60 。 C - 77 。 C and good dispersion in water when pH > 5.0. The water-casted films by SiO 2 -g-P(PEGMA)-b-P(PEG) obtain a little rough surface (Ra = 26.8 - 29.7 nm). While, the introduction of P(PEG) segments could slight increase the protein-repelling adsorption of SiO 2 -g-P(PEGMA)-b-P(PEG) films ( △ f = ?6.96 Hz ~ ?7.25 Hz) compared with SiO2-g-P(PEGMA) films ( △ f = ?9.5 Hz). Therefore, SiO2-g-P(PEGMA)-b-P(PEG) could be used as protein-resistance coatings.
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