Research ArticleOpen AccessGoogle Scholar indexed
Synthesis, Characterization and Anticancer Activity Studies of New Schiff Base Pt (II) Complex
Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen
Chemistry Department, Faculty of Applied Science, Thamar University, Thamar, Yemen
Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China
Department of Chemistry, Faculty of Education, Thamar University, Dhamar, Yemen
- 1 Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen
- 2 Chemistry Department, Faculty of Applied Science, Thamar University, Thamar, Yemen
- 3 Chemistry Department, Faculty of Pharmacy, University of Science & Technology, Sana’a, Yemen
- 4 CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China
- 5 Department of Chemistry, Faculty of Education, Thamar University, Dhamar, Yemen
Journal of Materials Science and Chemical Engineering·Volume 07 (2019)·Pages 1–8·Published 5 August 2019·DOI10.4236/msce.2019.78001
Copy link · social · email
Abstract
A New Schiff base ligand and its Pt (II) complex were synthesized. The ligand was prepared by condensation of 2-(4-isobutylphenyl)propanehydrazide with 2,3,4-trihydroxy benzaldehyde this novel ligand and its functional group was carefully designed and selected from well-known biological drugs. The structure of the ligand and its Pt-complex have been confirmed by spectroscopic data, i.e. elemental (CHN) analysis, FT-IR, electronic spectra, NMR spectra. The ligand and its Pt-complex were investigated for their in vitro anticancer potential using HeLa and PC3 cells. The Pt-complex showed a higher cytotoxic activity than the ligand towards Hela cells and PC3 cells.
KeywordsSchiff BaseComplexesPlatinumAnticancer Activity
- Naik, A., Annigeri, D., Gangardharmath, S.M.U., Ravankar, V.K., Mahale, V.B. and Reddv, V.K. (2002) Anchoring Mercapto-Triazoles on Dicarbonyl Backbone to Assemble Novel Binucleating, Acyclic SNONS Compartmental Ligands. Indian Journal of Chemistry—Section A, 41, 2046.
- Sen, A.K., Singh, G., Singh, K., Handa, R.N., Dubey, R.N. and Squattirito, P. (1998) Synthesis and Characterization of Some Monofunctional Bidentate Schiff Bases Derived from Cinnamaldehyde Ands-Triazoles, and Their Co(II), Ni(II), Cu(II) and Zn(II) Complexes. Proceedings of the Indian Academy of Sciences, 110, 75.
- Sen, A.K., Singh, G., Singh, K., Handa, R.N. and Dubey, S.N. (1997) Synthesis and Characterization of Some Monofunctional Bidentate Schiff Bases Derived from Furfuraldehyde and Their Cobalt(II), Nickel(II) and Copper(II) Complexes. Indian Journal of Chemistry A, 36, 891.
- El-Shekeil, A.G., Abdubakr, A.O., AlAghbari, S.A. and Nassar, M.Y. (2014) Anticancer 4: Anticancer and DNA Cleavage Studies of Some New Schiff Base Titanium (IV) Complexes. European Journal of Chemistry, 5, 410-414. https://doi.org/10.5155/eurjchem.5.3.410-414.996
- Chambhar, R.V., Khadse, B.G., Bobde, A.S. and Bahekar, H.R. (2003) Synthesis and Preliminary Evaluation of Some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d] pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno [2,3-d]pyrimidin-4-ones as Antimicrobial Agents. European Journal of Medicinal Chemistry, 38, 89-100.
- Rathelot, P., Azas N., Elkashef, H. and Delmas, F. (2002) 1,3-Diphenylpyrazoles: Synthesis and Antiparasitic Activities of Azomethine Derivatives. European Journal of Medicinal Chemistry, 37, 671-679. https://doi.org/10.1016/S0223-5234(02)01388-0
- Holla, B.S., Malini, K.V., Rao, B.S., Sarojini, B.K. and Kumari, N.S. (2003) Synthesis of Some New 2,4-Disubstituted Thiazoles as Possible Antibacterial and Anti-Inflammatory Agents. European Journal of Medicinal Chemistry, 38, 313-318.
- Holla, B.S., Veerendra, B., Shiramanda, M.K. and Poojary, B. (2003) Synthesis Characterization and Anticancer Activity Studies on Some Mannich Bases Derived from 1,2,4-Triazoles. European Journal of Medicine, 38, 759.
- Saleem, L.M.N. (1982) Trans-cis Isomerization of Schiff’s Bases (N-Benzylideneanilines) on Addition of Lanthanide Shift Reagents. Organic Magnetic Resonance, 19, 176-180. https://doi.org/10.1002/mrc.1270190403
- Wang, M., Wang, L.F., Li, Y.Z., Li, Q.X., Xu, Z.D. and Qu, D.Q. (2002) Antitumour Activity of Transition Metal Complexes with the Thiosemicarbazone Derived from 3-Acetylumbelliferone. Transition Metal Chemistry, 26, 307-310. https://doi.org/10.1023/A:1007159301849