Medicinal Plants Used in Management of Various Mental Illnesses in Goma City, Democratic Republic of Congo
Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
,
Department of Plant Sciences, Microbiology and Biotechnology, School of Biological Sciences, College of Natural Sciences, Makerere University Kampala, Uganda
,
Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
,
Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
,
Department of Internal Medicine, Faculty of Human Medicine, University of Goma (UNIGOM), Democratic Republic of Congo
,
Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda
1 Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
2 Department of Plant Sciences, Microbiology and Biotechnology, School of Biological Sciences, College of Natural Sciences, Makerere University Kampala, Uganda
3 Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
4 Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Mekerere University, Kampala, Uganda
5 Department of Internal Medicine, Faculty of Human Medicine, University of Goma (UNIGOM), Democratic Republic of Congo
6 Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University Kampala, Uganda
Many mentally ill people in Goma city, Democratic Republic of Congo (DRC), seek treatment from Traditional Health Practitioners (THPs) that utilize medicinal plants (MPs) in management of various ailments. The study aimed to document the MPs used locally to manage mental illnesses (MIs). An in-depth ethnobotanical survey including 43 respondents selected using snow ball method and interviewed using semi-structured questionnaires was conducted in Goma city, in DRC, from May to September 2021. Voucher specimens were collected from the study area and identified at Makerere University Herbarium (MHU). Data were analyzed using ethnobotanical parameters, frequency index, Rahman’s similarity index (RSI) and non-parametric tests as well as Spearman correlation coefficient. A total of 30 plant species, represented amongst 29 genera and 19 families were reportedly used to treat MIs. Of these 63.33% were reported for anxiety, 36.67% for psychosis and 30% for depression. Most abundant taxa were reported for three families including Asteraceae, Lamiaceae and Solanaceae. Among MPs used in Goma city, the two priority plant species for anxiety were Euphorbia abyssinica and Cleome gynandra L . While, the two priority plant species for depression were Conyza sumatrensis and Emilia coccinea . High similarity (RSI = 77.42%) was observed in the use of common species for MIs between THPs from both Goma and Karisimbi communes. Results prove that local people of Goma city use MPs species against MIs that could be further studied for pharmacological effectiveness and safety.
American Psychiatric Association (2000) Diagnostic and Statistical Manual-Text Revision (DSM-IV-TRim, 2000).
Charlson, F., van Ommeren, M., Flaxman, A., Cornett, J., Whiteford, H. and Saxena, S. (2019) New WHO Prevalence Estimates of Mental Disorders in Conflict Settings: A Systematic Review and Meta-Analysis. The Lancet, 394, 240-240. https://doi.org/10.1016/S0140-6736(19)30934-1
Si, S., Moss, J., Sullivam, T., Nowton, S. and Stoks, N. (2014) Effectiveness of General Practice-Based Health Check: A Systemic Review and Meta Analysis. Practice: The Journal of the Royal College of General Practitioner, 4, 47-53. https://doi.org/10.3399/bjgp14X676456
Depression WH (2017) Depression and Other Common Mental Disorders: Global Health Estimates. Geneva.
Mogga, J.L. (2019) The Mental Health Treatment Gap in South Sudan. South Sudan Medical Journal, 12, 28-29.
On’okoko, M.O., Jenkins, R., Miezi, S.M.M., Andjafono, D.O.L.E. and Mushidi, I.M. (2010) Mental Health in the Democratic Republic of Congo: A Post-Crisis Country Challenge. International Psychiatry, 7, 41-43. https://doi.org/10.1192/S1749367600005737
Kangoy, A.K., Muloye, G.M., Avevor, P.M. and Shixue, L. (2016) Mental Health Consequences of Being Raped in the Eastern Region of the Democratic Republic of Congo. Donnish Journal of Medicine and Medical Sciences, 3, 6-10.
Stephanie, E. (2016) Barriers to Mental Health Treatment with the Congolese Population.
Immigration and Refugee Board of Canada (2012) République Démocratique du Congo (RDC), information sur le traitement réservé aux personnes ayant des troubles de santé mentale. Protection et services offerts par l’état, COD104104. Commission d’immigration et de status des refugiés, UNHCR, 14 June. http://www.irbcisr.gc.ca:8080/RIR_RDI/RIRRDI.aspx?id=454030&l=f
Kosi, R.S. (2008) Au moins 15 millions de personnes atteintes des troubles mentaux en RDC. Le Potentiel, Kinshasa. https://www.refworld.org/docid/50eac4c92.html
Verelst, A., De Schryver, M., Broekaert, E. and Derluyn, I. (2014) Mental Health of Victims of Sexual Violence in Eastern Congo: Associations with Daily Stressors, Stigma, and Labeling. BMC Women’s Health, 14, 1-12. https://doi.org/10.1186/1472-6874-14-106
Mels, C., Derluyn, I., Broekaert, E. and Rosseel, Y. (2009) Screening for Traumatic Exposure and Posttraumatic Stress Symptoms in Adolescents in the War-Affected Eastern Democratic Republic of Congo. Archives of Pediatrics & Adolescent Medicine, 163, 525-530. https://doi.org/10.1001/archpediatrics.2009.56
Medicinal Plants Used in Management of Various Mental Illnesses in Goma City, Democratic Republic of Congo — Oak Academic Publishing
Dossa, N.I., Hatem, M., Zunzunegui, M.V. and Fraser, W. (2014) Social Consequences of Conflict-Related Rape: The Case of Survivors in the Eastern Democratic Republic of Congo. Peace and Conflict: Journal of Peace Psychology, 20, 241-255. https://doi.org/10.1037/pac0000044
Laudati, A.A. (2014) Negotiations and Networks in the Cannabis Trade in Eastern Democratic Republic of Congo. In: Drugs in Africa, Palgrave Macmillan, New York, 161-181. https://doi.org/10.1057/9781137321916_9
Meyer, P.K. (2018) Republique Demacratique du Congo: Developpement. Organisation Suisse d’Aide aux Refugies. Ritchie, H. Global Mental Health: Five Key Insights Which Emerge from the Data. Our World in Data, Online, 16 May.
World PsycShiatry (2007) The Concept of Mental Disorder. African Perspective, 6, 166-167.
Vancutsem, C., Pekel, J.F., Kibambe Lubamba, J.P., Blaes, X., de Wasseige, C. and Defourny, P. (2006) Carte de l’occupation du sol de la République Démocratique du Congo. UCL-Geomatics.
Edgerton, R.B. (1980) Traditional Treatment for Mental Illness in Africa: A Review. Culture, Medicine and Psychiatry, 4, 167-189. https://doi.org/10.1007/BF00051433
Lukongo, O.E. (2018) Trans-Border Trade, Minerals, and Civil War Impacts on Land Use and Land Cover Change in GOMA, Eastern Congo: An Integrated Geospatial Technologies and Political Economy Approach. International Journal of Advanced Robotics and Automation, 3, 1-12. https://doi.org/10.15226/2473-3032/3/1/00129
INS-Nord-Kivu (2016) Goma et ses avenues. Division Provincial du Plan, Goma.
T. g. C. t. (2013) Climate: Goma-Climate Graph. Climate-Data.org.
Malembaka, E.B., Altare, C., Bigirinama, R.N., Bisimwa, G., Banywesize, R., Tabbal, N. and Boerma, T. (2021) The Use of Health Facility Data to Assess the Effects of Armed Conflicts on Maternal and Child Health: Experience from the Kivu, DR Congo. BMC Health Services Research, 21, 1195. https://doi.org/10.1186/s12913-021-06143-7
A. F. P. Agency (2021) @AFPAfrica Map of DR Congo Locating Goma in Notth Kivu, Where Italy’s Ambassador to the Country Was Killed after Gunmen Attacked a UN Convoy, AFP Graphics.
Kumar, R. (2011) Research Methodology: A Step-by-Step Guide for Beginners. EC1Y 1SP, SAGE Publications Ltd., London. http://www.sagepublication.com
Kumar, R.V. (2014) Respondent Selection Methods in Household Surveys. International Management Institute, New Delhi, 1-9. http://www.sagepublication.com
Mashako, M. (2002) Arrêté Ministériel n˚ 1250/CAB MIN/S/CJ/KIZ/32/2002 du 25/ 10/2002 portant organisation de l’exercice de la médecine traditionnelle. Ministère congolais de la santé, RD. Congo. Kinshasa RDC, 8 p.
Pretorius, E. (1999) Traditional Healers. South African Health Review, 249, 256.
Boddy, C. (2016) Sample Size for Qualitative Research. Qualitative Market Research, 19, 426-432. https://doi.org/10.1108/QMR-06-2016-0053
Phillips, O.L. and Gentry, A.H. (1993) The Useful Plants of Tambopata, Peru: II. Additional Hypotheses Testing in Quantitative Ethnobotany. Economic Botany, 47, 33-43. https://doi.org/10.1007/BF02862204
Evert, T., Vandebroek, I., Sabino, S. and Van Damme, P. (2009) Cultural Significance of Medicinal Plant Families and Species among Quechua Farmers in Apillapampa, Bolivia. Journal of Ethnopharmacology, 122, 60-67. https://doi.org/10.1016/j.jep.2008.11.021
Trotter, R.T. and Logan, M.H. (1986) Informant Consensus: A New Approach for Identifying Potentially Effective Medicinal Plants. In: Etkin, N.L., Eds., Plants in Indigenous Medicine and Diet, Behavioural Approaches, Redgrave Publishing Company, New York, 91-112. https://doi.org/10.4324/9781315060385-6
Latham, P. and Konda Ku Mbuta, A. (2014) Useful Plants of Bas-Congo Province, Democratic Republic of Congo. Salvation Army, 2, 292.
Bakwaye, F.N., Termote, C., Kembelo, A.K. and Van Damme, P. (2015) Identification et importance locale des plantes médicinales utilisées dans la région de Mbanza-Ngungu, République démocratique du Congo. Bois & forêts des tropiques, 316, 63-77. https://doi.org/10.19182/bft2013.316.a20531
Heinrich, M. (2000) Ethnobotany and Its Role in Drug Development. Phytotherapy Research: PTR, 14, 479-488. https://doi.org/10.1002/1099-1573(200011)14:7 3.0.CO;2-2
Nachar, N. (2008) The Mann-Whitney U: A Test for Assessing Whether Two Independent Samples Come from the Same Distribution. Tutorials in Quantitative Methods for Psychology, 4, 13-20. https://doi.org/10.20982/tqmp.04.1.p013
Lesić, K.T., Brščić, K. and Ružić, M.D. (2017) The Importance of Understanding Event Experience. Tourism in South East Europe, 4, 605-618. https://doi.org/10.20867/tosee.04.26
Rahman, I.U., Afzal, A., Iqbal, Z., Hart, R., Ef, A.A., Hashem, A., Alsayed, M.F., Ijaz, F., Ali, N., Shah, M., Bussmann, R.W. and Calixto, E.S. (2019) A New Ethnobiological Similarity Index for the Evaluation of Novel Use Reports. Applied Ecology and Environmental Research, 17, 2765-2777. https://doi.org/10.15666/aeer/1702_27652777
Guenne, S., Balmus, I.M., Hilou, A., Ouattara, N., Kiendrebéogo, M., Ciobica, A. and Timofte, D. (2016) The Relevance of Asteraceae Family Plants in Most of the Neuropsychiatric Disorders Treatment. International Journal of Phytopharmacy, 8, 176-182.
Farzaneh, N., Mahmoud, M., Saeed, M. and Abdolbaset, G. (2005) Labiatae Family in folk Medicine in Iran. Iranian Journal of Pharmaceutical Research, 2, 63-79.
Zvezdina, E.V., Dayronas, J.V., Bochkareva, I.I., Zilfikarov, I.N., Babaeva, E.Yu., Ferubko, E.V., Guseynova, Z.A., Serebryanaya, F.K., Kaibova, S.R. and Ibragimov, T.A. (2020) Members of the Family Lamiaceae Lindl. as Sources of Medicinal Plant Raw Materials to Obtain Neurotropic Drugs. Pharmacy & Pharmacology, 8, 4-28. https://doi.org/10.19163/2307-9266-2020-8-1-4-28
Oksman-Caldentey, K.M. (2007) Tropane and Nicotine Alkaloid Biosynthesis-Novel Approaches towards Biotechnological Production of Plant-Derived Pharmaceuticals. Current Pharmaceutical Biotechnology, 8, 203-210. https://doi.org/10.2174/138920107781387401
Hashimoto, T., Yun, D.J. and Yamada, Y. (1993) Production of Tropane Alkaloids in Genetically Engineered Root Cultures. Phytochemistry, 32, 713-718. https://doi.org/10.1016/S0031-9422(00)95159-8
Bhattacharya, S.K., Bhattacharya, A., Sairam, K. and Ghosal, S. (2000) Anxiolytic-Antidepressant Activity of Withania somnifera Glycowithanolides: An Experimental Study. Phytomedicine, 7, 463-469. https://doi.org/10.1016/S0944-7113(00)80030-6
Pomilio, A.B., Falzoni, E.M. and Vitale, A.A. (2008) Toxic Chemical Compounds of the Solanaceae. Natural Product Communications, 3, 593-628. https://doi.org/10.1177/1934578X0800300420
Hannah, E.B., Joseph, S. and Oliver, F. (2012) How to Stabilize an Acutely. Current Psychiatry, 11, 10-16.
Grinchii, D. and Dremencov, E. (2020) Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders. International Journal of Molecular Sciences, 21, 9532. https://doi.org/10.3390/ijms21249532
Bhattarai, S. (2006) Ethnomedicinal Plants Used by the People of Manang District, Central Nepal. Journal of Ethnobiology and Ethnomedicine, 2, 41. https://doi.org/10.1186/1746-4269-2-41
Kumar, P. and Lalramnghinglova, H. (2011) India with Special Reference to an Indo-Burma Hotspot Region. Ethnobotany Research and Applications, 9, 379-342. https://doi.org/10.17348/era.9.0.379-420
Srithi, K., Balslev, H., Wangpakapattanawong, P., Srisanga, P. and Trisonthi, C. (2009) Medicinal Plant Knowledge and Its Erosion among the Mien (Yao) in Northern Thailand. Journal of Ethnopharmacology, 123, 335-342. https://doi.org/10.1016/j.jep.2009.02.035
Deviprasad, S. and Rambabu, D. (2021) Oral Drug Delivery of Nanomedicine. In: Theory and Applications of Nonparenteral Nanomedicines, Academic Press, Cambridge, 181-207. https://doi.org/10.1016/B978-0-12-820466-5.00009-0
Zhang, Q.W., Lin, L.G. and Ye, W.C. (2018) Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review. Chinese Medicine, 13, 1-26. https://doi.org/10.1186/s13020-018-0177-x
Remington, G., Addington, D., Honer, W., Ismail, Z., Raedler, T. and Teehan, M. (2017) Guidelines for the Pharmacotherapy of Schizophrenia in Adults. The Canadian Journal of Psychiatry, 62, 604-616. https://doi.org/10.1177/0706743717720448
Mary, A.K. (2009) Applied Therapeutics: The Chemical Use of Drugs. Lippincott Williams & Wilkins, Baltimore.
Levin, S. (2013) Encyclopedia of Biodiversity. Elsevier Inc., Amsterdam.
Kaur, R. and Kaur, S. (2015) Anxiolytic Potential of Methanol Extract from Ageratum Conyzoides Linn Leaves. Pharmacognosy Journal, 7, 236-241. https://doi.org/10.5530/pj.2015.4.5
Seol, G.H., Shim, H.S., Kim, P.J., Moon, H.K., Lee, K.H., Shim, I., Suh, S.H. and Min, S.S. (2010) Antidepressant-Like Effect of Salvia sclarea Is Explained by Modulation of Dopamine Activities in Rats. Journal of Ethnopharmacology, 130, 187-190. https://doi.org/10.1016/j.jep.2010.04.035
Ali, S.S., Abd El Wahab, M.G., Ayuob, N.N. and Suliaman, M. (2017) The Antidepressant-Like Effect of Ocimum basilicum in an Animal Model of Depression. Biotechnic & Histochemistry, 92, 390-401. https://doi.org/10.1080/10520295.2017.1323276
Jedi-Behnia, B., AbbasiMaleki, S. and Mousavi, E. (2017) The Antidepressant-Like Effect of Mentha spicata Essential Oil in Animal Models of Depression in Male Mice. Journal of Fasa University of Medical Sciences, 7, 141-149.
Machado, D.G., Neis, V.B., Balen, G.O., Colla, A., Cunha, M.P., Dalmarco, J.B., Pizzolatti, M.G., Prediger, R.D. and Rodrigues, A.L. (2012) Antidepressant-Like Effect of Ursolic Acid Isolated from Rosmarinus officinalis L. in Mice: Evidence for the Involvement of the Dopaminergic System. Pharmacology Biochemistry and Behavior, 103, 204-211. https://doi.org/10.1016/j.pbb.2012.08.016
Tiwari, A.T., Rathi, J.R., Dwivedi, S.K., Sanno, S. and Tripathi, S.T. (2018) Evaluation of Anti Anxiety Activity of Datura Seeds in Mice. International Journal of Indigenous Herbs and Drugs, 3, 23-24.
Jawad, M., Khan, H., Pervaiz, S., Bawazeer, S.S., Abu-Izneid, T., Saeed, M. and Kamal, M.A. (2017) Pharmacological Validation of the Anxiolytic, Muscle Relaxant and Sedative Like Activities of Capsicum annuum in Animal Model. Bangladesh Journal of Pharmacology, 12, 439-447. https://doi.org/10.3329/bjp.v12i4.33182
Lorigooini, Z., Dehsahraei, K.S., Bijad, E., Dehkordi, S.H. and Amini-Khoei, H. (2020) Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress. Pharmacology, 105, 289-299. https://doi.org/10.1159/000503728
Revathy, C. (2016) Neuropsychopharmacological Evaluation of Kalyanakam Kashayam (An Ayurvedic Formulation) in Swiss Albino Mice. Doctoral Dissertation, KMCH College of Pharmacy, Coimbatore.
Zu, X., Zhang, Z., Xiong, G., Liao, T., Qiao, Y., Li, Y., Geng, S. and Li, X. (2013) Sedative Effects of Arachis hypogaea L. Stem and Leaf Extracts on Sleep Deprived Rats. Experimental and Therapeutic Medicine, 6, 601-605. https://doi.org/10.3892/etm.2013.1182
Islam, S., Shajib, M.S., Datta, B.K. and Rashid, M.A. (2018) Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth. Bangladesh Pharmaceutical Journal, 21, 80-86. https://doi.org/10.3329/bpj.v21i2.37917
Kinda, P.T., Zerbo, P., Guenné, S., Compaoré, M., Ciobica, A. and Kiendrebeogo, M. (2017) Medicinal Plants Used for Neuropsychiatric Disorders Treatment in the Hauts Bassins Region of Burkina Faso. Medicines, 4, 32. https://doi.org/10.3390/medicines4020032
Umukoro, S. and Ashorobi, R.B. (2005) Anti-Stress Potential of Aqueous Seed Extract of Aframomum melegueta. African Journal of Biomedical Research, 8, 119-121. https://doi.org/10.4314/ajbr.v8i2.35771
Fajemiroye, J.O., Adam, K., Zjawiony Jordan, K., Alves, C.E. and Aderoju, A.A. (2018) Evaluation of Anxiolytic and Antidepressant-Like Activity of Aqueous Leaf Extract of Nymphaea lotus Linn. in Mice. Iranian Journal of Pharmaceutical Research: IJPR, 17, 613.
Begum, A., Biswas, P. and Shahed-Al-Mahmud, M. (2020) Methanol Extract of Spathodea campanulata P.(Beauv.) Leaves Demonstrate Sedative and Anxiolytic Like Actions on Swiss Albino Mice. Clinical Phytoscience, 6, 1-2. https://doi.org/10.1186/s40816-020-00182-z
Amin, K.R., Uddin, M.G., Rashid, M.M. and Sharmin, T. (2018) New Insight in Neuropharmacological Activities of Dioscorea alata. Discovery Phytomedicine, 5, 1-6. https://doi.org/10.15562/phytomedicine.2018.52
Deng, J., Zhou, Y., Bai, M., Li, H., Li, L. and Deng, J. (2010) Anxiolytic and Sedative Activities of Passiflora edulis f. Flavicarpa. Journal of Ethnopharmacology, 128, 148-153. https://doi.org/10.1016/j.jep.2009.12.043
Abubakar, A.R. and Haque, M. (2019) Medicinal Plants with Reported Anxiolytic and Sedative Activities in Nigeria: A Systematic Review. İstanbul Journal of Pharmacy, 49, 92-104. https://doi.org/10.26650/IstanbulJPharm.2019.18008
El-Fiky, F., Asres, K., Gibbons, S., Hammoda, H., Badr, J. and Umer, S. (2008) Phytochemical and Antimicrobial Investigation of Latex from Euphorbia abyssinica Gmel. Natural Product Communications, 3, 1505-1508. https://doi.org/10.1177/1934578X0800300922
Muluye, A.B., Desta, A.G., Abate, S.K. and Dano, G.T. (2019) Anti-Malarial Activity of the Root Extract of Eupharbia abyssinica (Euphorbiaceae) against Plasmodium berghei Infection in Mice. Malaria Journal, 12, 261. https://doi.org/10.1186/s12936-019-2887-7
USA Food and Drug Administration (2018) FDA Poisonous Plant Database. Food and Drug Administration of United States of America. https://www.accessdata.fda.gov/scripts/plantox/detail.cfm?id=23140
Bonsu, A.S. (2017) Studies on the Analgesic Effect and Toxicity Profile of Ethanolic Extractive of Desmodium adscendens in Rodents, Legon. University of Ghana School of Pharmacy, Accra.
Adhikari, P.P. and Paul, S.B. (2018) Medicinally Important Plant Cleome gyndra: A Phytochemical and Pharmacological Explanation. Asian Journal of Pharmaceutical and Clinical Research, 11, 21-29. https://doi.org/10.22159/ajpcr.2018.v11i1.22037
Mishra, S.S., Moharana, S.K. and Dash, M.R. (2011) Review on Cleome gynandra. International Journal of Research in Pharmacy and Chemistry, 1, 681-689.
Sarfaraz, S., Najam, R.A., Azhar, I., Riaz, B. and Anser, H.U. (2014) Anxiolytic and CNS Depressant Effects of Ethanolic Extract of Cleome Brachycarpa Revealed after Neuropharmacological Screening. World Journal of Pharmaceutical Sciences, 2, 605-610.
Justice, T.N. (2019) Anti-Convulsant and Sedative Effects of the Hydro-Ethanolic Whole Plant Extraction of Cleome rutidosperma (DC.) (Cleomeceae) in Mice. University of Ghana, Accra.
Eletta, O., Orimolade, B., Oluwaninyi, O. and Oo, D. (2017) Evaluation of Proximate and Antioxidant Activities of Ethiopian Eggplant (Solanum aethiopicum L) and Gboma Eggplant (Solanum macrocarpon L). Journal of Applied Sciences and Environmental Management, 21, 967-972. https://doi.org/10.4314/jasem.v21i5.25
Mary, O.O., Sebastine, O.U., Ejuiwa, M.C., Ikemefuna, O.I. and Dominic, E. (2020) Anxiolytic and Curative Effect of Solanum macrocarpon Leaves Extract on Acetaminophen Induced Brain Injury in Adult Wistar Rats. Journal of Pharmacognosy and Phytochemistry, 9, 205-212.
Oluwagunwa, O.A., Alashi, A.M. and Aluko, R.E. (2019) Solanum macrocarpon Leaf Extracts Reduced Blood Pressure and Heart Rate after Oral Administration to Spontaneously Hypertensive Rats. Current Topics in Nutraceutical Research, 17, 282-290. https://doi.org/10.37290/ctnr2641-452X.17:282-290
Boniface, P.K. and Pal, A. (2012) Substantiation of the Ethnopharmacological Use of Conyza sumatrensis (Retz.) E.H. Walker in the Treatment of Malaria through in Vivo Evaluation in Plasmodium berghei Infected Mice. Elsevier Ireland Ltd., Amsterdam.
Aiyelaagbe, O.O., Oguntoye, S.O., Hamid, A.A., Ogundare, A.M., Ojo, D.B., Ajao, A. and Owolabi, N.O. (2016) GC-MS Analysis, Antimicrobial and Antioxidant Activities of Extracts of the Aerial Parts of Conyza sumatrensis. Journal of Applied Sciences and Environmental Management, 20, 103-110. https://doi.org/10.4314/jasem.v20i1.13
Simplice, F.H., Abdou, B.A., Abaissou, N., Hervé, H., Lucy, M.F., Annabel, M.N., Nyenti, S., Neh, P. and Acha, A.E. (2014) Neuroprotective and Memory Improvement Effects of a Standardized Extract of Emilia coccinea (SIMS) G. on Animal Models of Anxiety and Depression. Journal of Pharmacognosy and Phytochemistry, 3, 146-154.
Bariyah, S.K., Ahmed, D. and Ikram, M. (2012) Ocimum basilicum: A Review on Phytochemical and Pharmacological Studies. Pakistan Journal of Chemistry, 2, 78-85. https://doi.org/10.15228/2012.v02.i02.p05
Sundaran, J. (2020) A Short Review on Pharmacological Activity of Cissus quadrangularis. Biomedical Informatics, 16, 579-585. https://doi.org/10.6026/97320630016579
He, X., Luan, F., Yang, Y., Wang, Z., Zhao, Z., Fang, J., Wang, M., Zuo, M. and Li, Y. (2020) Passiflora edulis: An Insight into Current Researches on Phytochemistry and Pharmacology. Frontiers in Pharmacology, 11, 617. https://doi.org/10.3389/fphar.2020.00617
Archer, M.A., Agyei, A., Mintah, S., Adjei, P., Kumadoh, D. and Asiedu-Larbi, J. (2019) Medicinal Uses of Cassia sieberiana; a Review. International Journal of Sciences: Basic and Applied Research, 48, 161-180.
Weckmüller, H., Barriocanal, C., Maneja, R. and Boada, M. (2019) Factors Affecting Traditional Medicinal Plant Knowledge of the Waorani, Ecuador. Sustainability, 11, 2-12. https://doi.org/10.3390/su11164460
Reyes-García, V., Guèze, M., Luz, A., Paneque-Gálvez, J., Macía, M., Orta-Martínez, M., Pino, J. and Rubio-Campillo, X. (2013) Evidence of Traditional Knowledge Loss among a Contemporary Indigenous Society. Evolution and Human Behavior, 34, 249-257. https://doi.org/10.1016/j.evolhumbehav.2013.03.002
Camou-Guerrero, A., Reyes-García, V., Martínez-Ramos, M. and Casas, A. (2008) Knowledge and Use Value of Plant Species in a Rarámuri Community: A Gender Perspective for Conservation. Human Ecology, 36, 259-272. https://doi.org/10.1007/s10745-007-9152-3
Coe, F. and Anderson, G. (1996) Screening of Medicinal Plants Used by the Garífuna of Eastern Nicaragua for Bioactive Compounds. Journal of Ethnopharmacology, 53, 29-50. https://doi.org/10.1016/0378-8741(96)01424-9
Abdullahi, A.A. (2011) Trends and Challenges of Traditional Medicine in Africa. African Journal of Traditional, Complementary and Alternative Medicines, 8, 115-123. https://doi.org/10.4314/ajtcam.v8i5S.5
Matavele, J. and Habib, M. (2000) Ethnobotany in Cabo Delgado, Mozambique: Use of Medicinal Plants. Environment, Development and Sustainability, 2, 227-234. https://doi.org/10.1023/A:1011414124429
Begossi, A., Hanazaki, N. and Tamashiro, J. (2002) Medicinal Plants in the Atlantic Forest (Brazil): Knowledge, Use, and Conservation. Human Ecology, 30, 281-299. https://doi.org/10.1023/A:1016564217719
Merétika, A., Peroni, N. and Hanazaki, N. (2010) Local Knowledge of Medicinal Plants in Three Artisanal Fishing Communities (Itapoá, Southern Brazil), According to Gender, Age, and Urbanization. Acta Botanica Brasilica, 24, 386-394. https://doi.org/10.1590/S0102-33062010000200009
Voeks, R. and Leony, A. (2004) Forgetting the Forest: Assessing Medicinal Plant Erosion in Eastern Brazil. Economic Botany, 58, S294-S306. https://doi.org/10.1663/0013-0001(2004)58[S294:FTFAMP]2.0.CO;2
Figueiredo, G., Leitao-Filho, H. and Begossi, A. (1997) Ethnobotany of Atlantic Forest Coastal Communities: II. Diversity of Plant Uses at Sepetiba Bay (SE Brazil). Human Ecology, 25, 353-360. https://doi.org/10.1023/A:1021934408466
Osemene, K.P., Elujoba, A.A. and Ilori, M.O. (2011) An Overview of Herbal Medicine. Research and Development in Nigeria. Research Journal of Medical Sciences, 5, 8. https://doi.org/10.3923/rjmsci.2011.228.232
Owuor, J. (2007) Integrating African Indigenous Knowledge in Kenya’s Formal Education System: The Potential for Sustainable Development. Journal of Contemporary Issues in Education, 2, 21-37. https://doi.org/10.20355/C5Z594
Weckmüller, H., Barriocanal, C., Maneja, R., Boada, M. and Weckmüller, H. (2019) Factors Affecting Traditional Medicinal Plant Knowledge of the Waorani, Ecuador. Sustainability, 11, 4460. https://doi.org/10.3390/su11164460