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Creutzfeldt Jacob’s Disease: A Senegalese Observation

¹ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
² Department of Neurology, Pikine Hospital, Dakar, Sénégal
³ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
⁴ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
⁵ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
⁶ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
⁷ Department of Radiology, Fann Hospital, Dakar, Sénégal
⁸ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
⁹ Department of Neurology, Pikine Hospital, Dakar, Sénégal
¹⁰ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
¹¹ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
¹² Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
¹³ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal
¹⁴ Department of Ibrahima Pierre Ndiaye Neuroscience, Fann Hospital, Dakar, Sénégal

Neuroscience and Medicine·Volume 13 (2022)·Pages 43–48·Published 22 February 2022·DOI10.4236/nm.2022.131003

Abstract

Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.

KeywordsCreutzfeldt-Jakob DiseaseProtein 14-3-3Prion DiseaseRapidly Progressive Dementia

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Creutzfeldt Jacob’s Disease: A Senegalese Observation

Abstract

References (10)