Magnetic Resonance Imaging (MRI) is commonly applied to clinical diagnostics owing to its high soft-tissue contrast and lack of invasiveness. However, its sensitivity to noise, attributable to hardware limitations, patient motion, and acquisition parameters, remains a long-term source of concern that normally leads to impaired diagnostic accuracy. Traditional denoising filters such as Gaussian, Wavelet, Anisotropic Diffusion, and Non-Local Means (NLM) have previously been employed to reduce these issues, but at the cost of typically sacrificing noise removal against structural detail. More recent advances in deep learning, in particular Convolutional Neural Networks (CNNs), have indicated excellent promise in overcoming these limitations in being capable of learning data-driven, highly robust feature representations. This study proposes and compares an extensive denoising pipeline that unites CNNs with both classical and hybrid filters to improve the quality of MRI images. The pipeline encompasses not only independent classical filters but also new hybrid pipelines like NLM-Gaussian Fusion, NLM-Gaussian Sequential, and Wavelet-Anisotropic Diffusion (WAD), all enriched with deep CNNs. Experiments were performed using a publicly shared MRI dataset of 5141 training images and 1279 test images. Performance was gauged using Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index (SSIM), and Mean Squared Error (MSE). Results show that while the Wavelet filter performed best as a standalone denoising filter, when CNNs were integrated with hybrid filters, there were monumental improvements in all metrics tried, with the pipeline of NLM-Gaussian Fusion + CNN achieving a PSNR of 30.4 and SSIM of 0.65. Moreover, visualizations such as SSIM heatmaps and loss-epoch convergence plots supported the efficacy of the proposed models in preserving structural information. The study reveals that the use of CNNs with conventional and hybrid filters offers synergistic benefits, especially for low-resource clinical setups where denoising quality is paramount. The novelty in this research comes from its systematic benchmarking of traditional as well as hybrid filtering pipelines supplemented with CNNs, providing empirical evidence for their utility in real-world medical imaging scenarios. These findings not only contribute to the widening ambit of AI-assisted image reconstruction but also provide functional avenues towards enhancing the dependability of diagnosis in resource-scarce healthcare environments.
Ghadimi, M. and Thomas, A. (2025) Magnetic Resonance Imaging Contraindications. StatPearls Publishing.
Safari, M., Eidex, Z., Chang, C.-W., Qiu, R.L.J. and Yang, X. (2024) Fast MRI Reconstruction Using Deep Learning-Based Compressed Sensing: A Systematic Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC11092677/
Obungoloch, J., Harper, J.R., Consevage, S., Savukov, I.M., Neuberger, T., Tadigadapa, S., et al . (2018) Design of a Sustainable Prepolarizing Magnetic Resonance Imaging System for Infant Hydrocephalus. Magnetic Resonance Materials in Physics , Biology and Medicine , 31, 665-676. https://doi.org/10.1007/s10334-018-0683-y
Zhang, K., Zuo, W., Chen, Y., Meng, D. and Zhang, L. (2016) Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising. IEEE Transactions on Image Processing , 26, 3142-3155. https://doi.org/10.1109/tip.2017.2662206
Wüthrich, M., Trimpe, S., Garcia Cifuentes, C., Kappler, D. and Schaal, S. (2016) A New Perspective and Extension of the Gaussian Filter. The International Journal of Robotics Research , 35, 1731-1749. https://doi.org/10.1177/0278364916684019
Perona, P. and Malik, J. (1990) Scale-Space and Edge Detection Using Anisotropic Diffusion. IEEE Transactions on Pattern Analysis and Machine Intelligence , 12, 629-639. https://doi.org/10.1109/34.56205
Kundu, R., Chakrabarti, A. and Lenka, P. (2014) An Approach for Reducing Outliers of Non Local Means Image Denoising Filter. https://arxiv.org/abs/1412.2444
Donoho, D.L., Johnstone, I.M., Kerkyacharian, G. and Picard, D. (1995) Wavelet Shrinkage: Asymptopia? Journal of the Royal Statistical Society Series B : Statistical Methodology , 57, 301-337. https://doi.org/10.1111/j.2517-6161.1995.tb02032.x
Chen, H., Zhang, Y., Chen, Y., Zhang, J., Zhang, W., Sun, H., et al . (2018) LEARN: Learned Experts’ Assessment-Based Reconstruction Network for Sparse-Data CT. IEEE Transactions on Medical Imaging , 37, 1333-1347. https://doi.org/10.1109/tmi.2018.2805692
Mienye, I.D., Swart, T.G., Obaido, G., Jordan, M. and Ilono, P. (2025) Deep Convolutional Neural Networks in Medical Image Analysis: A Review. Information , 16, 195. https://doi.org/10.3390/info16030195
Li, M., Jiang, Y., Zhang, Y. and Zhu, H. (2023) Medical Image Analysis Using Deep Learning Algorithms. Frontiers in Public Health , 11, Article 1273253. https://doi.org/10.3389/fpubh.2023.1273253
Image Quality Enhancement
Medical Image Processing
Chen, H., Zhang, Y., Kalra, M.K., Lin, F., Chen, Y., Liao, P., et al . (2017) Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network. IEEE Transactions on Medical Imaging , 36, 2524-2535. https://doi.org/10.1109/tmi.2017.2715284
Li, Q., Li, X., Lee, B. and Kim, J. (2021) A Hybrid CNN-Based Review Helpfulness Filtering Model for Improving E-Commerce Recommendation Service. Applied Sciences , 11, Article 8613. https://doi.org/10.3390/app11188613
Kidoh, M., Shinoda, K., Kitajima, M., Isogawa, K., Nambu, M., Uetani, H., et al . (2019) Deep Learning Based Noise Reduction for Brain MR Imaging: Tests on Phantoms and Healthy Volunteers. Magnetic Resonance in Medical Sciences , 19, 195-206. https://doi.org/10.2463/mrms.mp.2019-0018
Nazir, N., Sarwar, A. and Saini, B.S. (2024) Recent Developments in Denoising Medical Images Using Deep Learning: An Overview of Models, Techniques, and Challenges. Micron , 180, Article 103615. https://doi.org/10.1016/j.micron.2024.103615
El-Shafai, W., El-Nabi, S.A., Ali, A.M., El-Rabaie, E.M. and Abd El-Samie, F.E. (2024) Traditional and Deep-Learning-Based Denoising Methods for Medical Images. Multimedia Tools and Applications , 83, 52061-52088. https://doi.org/10.1007/s11042-023-14328-x
Muksimova, S., Umirzakova, S., Mardieva, S. and Cho, Y. (2023) Enhancing Medical Image Denoising with Innovative Teacher–Student Model-Based Approaches for Precision Diagnostics. Sensors , 23, Article 9502. https://doi.org/10.3390/s23239502
Kumar, R.R. and Priyadarshi, R. (2024) Denoising and Segmentation in Medical Image Analysis: A Comprehensive Review on Machine Learning and Deep Learning Approaches. Multimedia Tools and Applications , 84, 10817-10875. https://doi.org/10.1007/s11042-024-19313-6
Rai, S., Bhatt, J.S. and Patra, S.K. (2021) An Unsupervised Deep Learning Framework for Medical Image Denoising. https://arxiv.org/pdf/2103.06575
Chaturvedi, S., T, A.S.S., R, K., M, V., A, N.K. and M, S. (2022) Medical Image Denoising and Classification Based on Machine Learning: A Review. ECS Transactions , 107, 6111-6122. https://doi.org/10.1149/10701.6111ecst
Zhang, J., Niu, Y., Shangguan, Z., Gong, W. and Cheng, Y. (2023) A Novel Denoising Method for CT Images Based on U-Net and Multi-Attention. Computers in Biology and Medicine , 152, Article 106387. https://doi.org/10.1016/j.compbiomed.2022.106387
Tian, C., Xu, Y., Li, Z., Zuo, W., Fei, L. and Liu, H. (2020) Attention-Guided CNN for Image Denoising. Neural Networks , 124, 117-129. https://doi.org/10.1016/j.neunet.2019.12.024
Ilesanmi, A.E. and Ilesanmi, T.O. (2021) Methods for Image Denoising Using Convolutional Neural Network: A Review. Complex & Intelligent Systems , 7, 2179-2198. https://doi.org/10.1007/s40747-021-00428-4
Tiantian, W., Hu, Z. and Guan, Y. (2024) An Efficient Lightweight Network for Image Denoising Using Progressive Residual and Convolutional Attention Feature Fusion. Scientific Reports , 14, Article No. 9554. https://doi.org/10.1038/s41598-024-60139-x
Mukhopadhyay, S. and Mandal, J.K. (2013) Wavelet Based Denoising of Medical Images Using Sub-Band Adaptive Thresholding through Genetic Algorithm. Procedia Technology , 10, 680-689. https://doi.org/10.1016/j.protcy.2013.12.410
Buades, A., Coll, B. and Morel, J.M. (2005) A Non-Local Algorithm for Image Denoising. 2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition ( CVPR ’05), San Diego, 20-25 June 2005, 60-65. https://doi.org/10.1109/cvpr.2005.38
Taassori, M. and Vizvári, B. (2024) Enhancing Medical Image Denoising: A Hybrid Approach Incorporating Adaptive Kalman Filter and Non-Local Means with Latin Square Optimization. Electronics , 13, Article 2640. https://doi.org/10.3390/electronics13132640
Zhang, Y., Hao, D., Lin, Y., Sun, W., Zhang, J., Meng, J., et al . (2023) Structure-Preserving Low-Dose Computed Tomography Image Denoising Using a Deep Residual Adaptive Global Context Attention Network. Quantitative Imaging in Medicine and Surgery , 13, 6528-6545. https://doi.org/10.21037/qims-23-194
Xie, J., Xu, L. and Chen, E. (2012) Image Denoising and Inpainting with Deep Neural Networks. Advances in Neural Information Processing Systems , 25. https://proceedings.neurips.cc/paper/2012/hash/6cdd60ea0045eb7a6ec44c54d29ed402-Abstract.html
Lundervold, A.S. and Lundervold, A. (2019) An Overview of Deep Learning in Medical Imaging Focusing on MRI. Zeitschrift für Medizinische Physik , 29, 102-127. https://doi.org/10.1016/j.zemedi.2018.11.002
Chen, Z., Pawar, K., Ekanayake, M., Pain, C., Zhong, S. and Egan, G.F. (2022) Deep Learning for Image Enhancement and Correction in Magnetic Resonance Imaging—State-of-the-Art and Challenges. Journal of Digital Imaging , 36, 204-230. https://doi.org/10.1007/s10278-022-00721-9
Organización Mundial de la Salud (2017) Global Atlas of Medical Devices 2022. World Health Organization. https://www.who.int/publications/i/item/9789240062207
Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K., et al . (2019) A Guide to Deep Learning in Healthcare. Nature Medicine , 25, 24-29. https://doi.org/10.1038/s41591-018-0316-z