Peripheral Neuropathies Associated with Gammopathies in the Outpatient Clinic of the Neurology Department at the University Hospital Center of Libreville: Study of Two Cases and Literature Review
- 1 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 2 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 3 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 4 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 5 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 6 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 7 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 8 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 9 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 10 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 11 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 12 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
- 13 Department of Neurology, University Hospital Center of Libreville, Libreville, Gabon
Abstract
Introduction: Peripheral neuropathies associated with gammopathies are common after the age of 55 years. However, serum protein electrophoresis is not systematically performed in the etiological workup of neuropathy. Objective: to describe cases the clinical profiles of patients with peripheral neuropathy and co-occuring gammopathy and highlight associated diagnostic challenges in our clinical setting. Methodology: This retrospective and prospective descriptive study, conducted in the neurology department of CHUL, reported observations of two female patients, aged 73 and 62 years, respectively, who presented in consultation with clinical signs suggestive of peripheral neuropathy, subsequently confirmed by electroneuromyography, and whose investigations revealed gammopathy. Results and Conclusion: Peripheral neuropathies associated with gammopathies should be systematically investigated, as they are not uncommon. They primarily affect elderly women, who often present with bilateral carpal tunnel syndrome, with or without an associated neuropathy. Etiological evaluation, in our context, is often limited once additional diagnostic tests are pursued. However, in the presence of certain gammopathies, it is essential to rule out malignant hematological disorders.
- Gnigone, P.M., Nyangui Mapaga, J., Mwanyombet, S., Mambila Matsalou, G.A., Diouf Mbourou, N., Nsounda, A.A., et al . (2022) Prevalence and Factors Associated with Major Neurological Disorders in the General Population in the Communes of Akanda and Owendo in 2022. Bulletin Médical d ’ Owendo , 20, 39-47. http://www.lebmo.org/prevalence-et-facteurs-associes-aux-affections-neurologiques-majeures-en-population-generale-dans-les-communes-dakanda-et-d-owendo-en-2022
- Karfo, R., Benchekroun, L., Zohoun, A. and Chabraoui, L. (2015) Difficulties in Interpreting the Monoclonal Gammopathy of Chance Discovery: Transitional Gammopathy Case in a Significant Inflammatory Syndrome. Annales de Biologie Clinique , 73, 495-497. https://doi.org/10.1684/abc.2015.1068
- Lacour, A. (2015) Chronic Axonal Polyneuropathy of Undetermined Cause: What Should Be Considered? Revue Neurologique , 171, A232. https://doi.org/10.1016/j.neurol.2015.01.527
- Lacour, A. (2013) Etiological Exploration of Peripheral Neuropathies.
- Perlot, Q., Hermans, C. and Vekemans, M.-C. (2023) Rare Manifestations of Monoclonal Gammopathies: Report of Two Cases and Literature Review. La Revue de Médecine Interne , 44, 307-310. https://doi.org/10.1016/j.revmed.2023.03.005
- Hamza, N., Hdiji, O., Farhat, N., Sakka, S., Kacem, H.H., Bouattour, N., et al . (2018) Peripheral Neuropathies in Dysglobulinemias. Neurophysiologie Clinique , 48, 134. https://doi.org/10.1016/j.neucli.2018.05.016
- Serraj, K., Mebrouk, Y., Hamaz, S., Bachir, H., Alaoui, H. and Andrès, E. (2018) Peripheral Neuropathies and Monoclonal Gammopathies.
- Rajkumar, S.V., Dimopoulos, M.A., Palumbo, A., Blade, J., Merlini, G., Mateos, M., et al . (2014) International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma. The Lancet Oncology , 15, e538-e548. https://doi.org/10.1016/s1470-2045(14)70442-5
- Sellier Montaigne, L., Delmont, E., Gendre, T., Pegat, A., Tard, C., Pereon, Y., et al . (2025) Neuropathies Associated with an IgM Gammopathy: When There Is No Anti-MAG. Revue Neurologique , 181, S110. https://doi.org/10.1016/j.neurol.2025.01.216
- Lenglet, T. and Camdessanché, J-P. (2020) Diagnostic Strategy for Peripheral Neuropathy. Pratique Neurologique - FMC , 11, 101-108. https://doi.org/10.1016/j.praneu.2020.01.006