Assessment of Global Fatigue in Multiple Sclerosis: A Spanish Language Version of the CGI and PGI Fatigue Scales
- 1 Clintara LLC, Boston, USA;
- 2 Institute of Neurosciences at Favaloro University, Buenos Aires, Argentina;
- 3 Institute of Neurosciences at Favaloro University, Buenos Aires, Argentina;
- 4 Clintara LLC, Boston, USA;
- 5 Institute of Neurosciences at Favaloro University, Buenos Aires, Argentina;
Abstract
Background: Fatigue is often identified as weakness following muscular exertion in patients with multiple sclerosis (MS) but may be associated with other physical, cognitive and emotional symptoms. Objective: To develop a Spanish language global impression of fatigue scale s to evaluate symptoms of fatigue distinct from a particular disease. Methods: 50 ambulatory patients with MS attending a clinical institute in Argentina consented to participate in this reliability study. The Spanish language version of the Clinical and Patient Global Impressions of Fatigue (CGI-S-F and PGI-S-F) instruments were administered with the Massachusetts General Hospital cognitive and physical functioning question naire (MGH-CPFQ). Results: The CGI-S-F and PGI-S-F scores were well correlated with each other ( p < 0.00005). The mean CGI-S for fatigue was 2.28 ± 1.07 (SD) and PGI-S for fatigue was 2.30 ± 1.16 ( p = ns) reflecting borderline to mild perception of fatigue. The total MGH-CPFQ was 16.68 ± 4.32. Both CGI-S-F and PGI-S-F measures were cor related with the MGH-CPFQ: CGI-Severity ( r = 0.632; p < 0.00005); PGI-Severity ( r = 0.717; p < 0.00005). Conclu sions : In this study, the Spanish language versions of the CGI-S-F and PGI-S-F were reliable measures in an MS popu lation and can be useful and easily applied metrics in a busy clinical practice.
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